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E7F6T8

- UBP37_DANRE

UniProt

E7F6T8 - UBP37_DANRE

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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

usp37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei331 – 3311NucleophilePROSITE-ProRule annotation
Active sitei866 – 8661Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein K11-linked deubiquitination Source: UniProtKB
  4. protein K48-linked deubiquitination Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.046.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:usp37
ORF Names:zgc:152882, zgc:153999
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-061013-802. usp37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412648Add
BLAST

Expressioni

Gene expression databases

BgeeiE7F6T8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076736.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 911590USPAdd
BLAST
Repeati672 – 69120UIM 1Add
BLAST
Repeati766 – 78520UIM 2Add
BLAST
Repeati788 – 80720UIM 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 403KEN box 1By similarity
Motifi76 – 849D-box 1By similarity
Motifi101 – 11010D-box 2By similarity
Motifi162 – 1709D-box 3By similarity
Motifi204 – 2063KEN box 2By similarity
Motifi742 – 7443KEN box 3By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiE7F6T8.
KOiK11850.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7F6T8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVPRLTS GGAVRIRIRC GELGTTKWRE GVIEIQERDN KINLLVKFNS
60 70 80 90 100
GGAPRVFQLS HNVKSVSWFQ THGPNRMTLT LKDSCIVMMD KLNMLVAKKM
110 120 130 140 150
KEYLETVKLG KPAVFKTNQG SASFGLVLGN RTAQNDSGLS PSDKQSAPRR
160 170 180 190 200
SSLDSREDST PRKPLGSPSR VTSTPARGSL SEIRSEKRKR LMNSDGDLTE
210 220 230 240 250
DYPKENDSSS NNKAITDSSR KFLLSCKDKL KQSEENRASA PHTPAPLQPT
260 270 280 290 300
SFYGSRTGAK DYTQTHSFLD RPSSTGSCPS AKRSLVLPNH STPFKKVRPT
310 320 330 340 350
LDYGGWNKPR PSVLAQPQPP LQGFSNLGNT CYMNAILQSL FSLPSFSNDL
360 370 380 390 400
LKQGIPWKRV PINALLRRFA HLLAKKDISP PEVKKDLLRR VKNAISSTAE
410 420 430 440 450
RFSGYMQNDA HEFLSQCLDQ LKEDVEKINK SWKNEPSAWD EPQSTRLADE
460 470 480 490 500
VDTSRIYTCP VTVNMEFEVQ HTITCKSCGE VVLKREQFND LSIDLPRRRK
510 520 530 540 550
TLPMRSIQDS LDLFFRMEEI EYSCEKCSGK AATVSHKFSR LPRVLILHLK
560 570 580 590 600
RYSYNTQLSL NSKLGQQVLI PKYLTLLSHC TDATRSPLSL GWSAQNALSR
610 620 630 640 650
TLKISQSVNS STLRRASQRP ESSGSVLCDS DSDEELVRKV ARKHHPDDDR
660 670 680 690 700
ADELQQHHPH AAVEQSEFNG INDEEMLAAV LEMSRHDTSL CAGPDEEPSS
710 720 730 740 750
SPDTGFGDAD AHDLTQHLEL LDAEKQPTDA LESLDLTMDE NKENQTPDGL
760 770 780 790 800
QGELDWVQQY SLEQEREEQE LQQALAQSLQ EQEAREMRED DDLKRATELS
810 820 830 840 850
LQEFNNSLPE LLCSDEDSGN EDGLDMEYSE AEAEELKKNA ETGELPNSFR
860 870 880 890 900
LISVVSHIGS SSSSGHYISD VYDMKKQSWL TYNDLDVSRT QESTVQRDRD
910 920 930
RSGYIFFYMH KDVFEELSEL EKAGVNTDGG RTVLQPL
Length:937
Mass (Da):105,264
Last modified:March 8, 2011 - v1
Checksum:i6B483279C5C4EB83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791L → Q in AAI24597. 1 PublicationCurated
Sequence conflicti106 – 1061T → N in AAI24597. 1 PublicationCurated
Sequence conflicti106 – 1061T → N in AAI29041. 1 PublicationCurated
Sequence conflicti155 – 1551S → N in AAI24597. 1 PublicationCurated
Sequence conflicti155 – 1551S → N in AAI29041. 1 PublicationCurated
Sequence conflicti180 – 1801L → F in AAI24597. 1 PublicationCurated
Sequence conflicti180 – 1801L → F in AAI29041. 1 PublicationCurated
Sequence conflicti445 – 4451T → M in AAI24597. 1 PublicationCurated
Sequence conflicti445 – 4451T → M in AAI29041. 1 PublicationCurated
Sequence conflicti531 – 5311A → V in AAI24597. 1 PublicationCurated
Sequence conflicti531 – 5311A → V in AAI29041. 1 PublicationCurated
Sequence conflicti615 – 6151R → K in AAI24597. 1 PublicationCurated
Sequence conflicti615 – 6151R → K in AAI29041. 1 PublicationCurated
Sequence conflicti634 – 6341E → V in AAI24597. 1 PublicationCurated
Sequence conflicti653 – 6531E → EQ in AAI24597. 1 PublicationCurated
Sequence conflicti654 – 6563LQQ → HHH in AAI29041. 1 PublicationCurated
Sequence conflicti654 – 6563LQQ → HHH in AAI24597. 1 PublicationCurated
Sequence conflicti734 – 7341L → P in AAI24597. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT583711 Genomic DNA. No translation available.
BC124596 mRNA. Translation: AAI24597.1.
BC129040 mRNA. Translation: AAI29041.1.
RefSeqiNP_001070811.1. NM_001077343.1.
UniGeneiDr.150626.

Genome annotation databases

EnsembliENSDART00000129632; ENSDARP00000110966; ENSDARG00000040990.
GeneIDi768201.
KEGGidre:768201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT583711 Genomic DNA. No translation available.
BC124596 mRNA. Translation: AAI24597.1 .
BC129040 mRNA. Translation: AAI29041.1 .
RefSeqi NP_001070811.1. NM_001077343.1.
UniGenei Dr.150626.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000076736.

Protein family/group databases

MEROPSi C19.046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000129632 ; ENSDARP00000110966 ; ENSDARG00000040990 .
GeneIDi 768201.
KEGGi dre:768201.

Organism-specific databases

CTDi 57695.
ZFINi ZDB-GENE-061013-802. usp37.

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00440000033542.
HOGENOMi HOG000060197.
HOVERGENi HBG055893.
InParanoidi E7F6T8.
KOi K11850.

Miscellaneous databases

NextBioi 20918515.
PROi E7F6T8.

Gene expression databases

Bgeei E7F6T8.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view ]
SMARTi SM00726. UIM. 3 hits.
[Graphical view ]
PROSITEi PS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUBP37_DANRE
AccessioniPrimary (citable) accession number: E7F6T8
Secondary accession number(s): A1L1F9
, E7FBK6, F1QUQ3, Q08BR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3