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E7F6T8

- UBP37_DANRE

UniProt

E7F6T8 - UBP37_DANRE

Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

usp37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei331 – 3311NucleophilePROSITE-ProRule annotation
    Active sitei866 – 8661Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. protein K11-linked deubiquitination Source: UniProtKB
    4. protein K48-linked deubiquitination Source: UniProtKB
    5. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.053.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 37
    Ubiquitin thioesterase 37
    Ubiquitin-specific-processing protease 37
    Gene namesi
    Name:usp37
    ORF Names:zgc:152882, zgc:153999
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 9

    Organism-specific databases

    ZFINiZDB-GENE-061013-802. usp37.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 937937Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412648Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiE7F6T8.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000076736.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini322 – 911590USPAdd
    BLAST
    Repeati672 – 69120UIM 1Add
    BLAST
    Repeati766 – 78520UIM 2Add
    BLAST
    Repeati788 – 80720UIM 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 403KEN box 1By similarity
    Motifi76 – 849D-box 1By similarity
    Motifi101 – 11010D-box 2By similarity
    Motifi162 – 1709D-box 3By similarity
    Motifi204 – 2063KEN box 2By similarity
    Motifi742 – 7443KEN box 3By similarity

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5560.
    GeneTreeiENSGT00440000033542.
    HOGENOMiHOG000060197.
    HOVERGENiHBG055893.
    InParanoidiQ08BR8.
    KOiK11850.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR003903. Ubiquitin-int_motif.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02809. UIM. 3 hits.
    [Graphical view]
    SMARTiSM00726. UIM. 3 hits.
    [Graphical view]
    PROSITEiPS50330. UIM. 2 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7F6T8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVPRLTS GGAVRIRIRC GELGTTKWRE GVIEIQERDN KINLLVKFNS    50
    GGAPRVFQLS HNVKSVSWFQ THGPNRMTLT LKDSCIVMMD KLNMLVAKKM 100
    KEYLETVKLG KPAVFKTNQG SASFGLVLGN RTAQNDSGLS PSDKQSAPRR 150
    SSLDSREDST PRKPLGSPSR VTSTPARGSL SEIRSEKRKR LMNSDGDLTE 200
    DYPKENDSSS NNKAITDSSR KFLLSCKDKL KQSEENRASA PHTPAPLQPT 250
    SFYGSRTGAK DYTQTHSFLD RPSSTGSCPS AKRSLVLPNH STPFKKVRPT 300
    LDYGGWNKPR PSVLAQPQPP LQGFSNLGNT CYMNAILQSL FSLPSFSNDL 350
    LKQGIPWKRV PINALLRRFA HLLAKKDISP PEVKKDLLRR VKNAISSTAE 400
    RFSGYMQNDA HEFLSQCLDQ LKEDVEKINK SWKNEPSAWD EPQSTRLADE 450
    VDTSRIYTCP VTVNMEFEVQ HTITCKSCGE VVLKREQFND LSIDLPRRRK 500
    TLPMRSIQDS LDLFFRMEEI EYSCEKCSGK AATVSHKFSR LPRVLILHLK 550
    RYSYNTQLSL NSKLGQQVLI PKYLTLLSHC TDATRSPLSL GWSAQNALSR 600
    TLKISQSVNS STLRRASQRP ESSGSVLCDS DSDEELVRKV ARKHHPDDDR 650
    ADELQQHHPH AAVEQSEFNG INDEEMLAAV LEMSRHDTSL CAGPDEEPSS 700
    SPDTGFGDAD AHDLTQHLEL LDAEKQPTDA LESLDLTMDE NKENQTPDGL 750
    QGELDWVQQY SLEQEREEQE LQQALAQSLQ EQEAREMRED DDLKRATELS 800
    LQEFNNSLPE LLCSDEDSGN EDGLDMEYSE AEAEELKKNA ETGELPNSFR 850
    LISVVSHIGS SSSSGHYISD VYDMKKQSWL TYNDLDVSRT QESTVQRDRD 900
    RSGYIFFYMH KDVFEELSEL EKAGVNTDGG RTVLQPL 937
    Length:937
    Mass (Da):105,264
    Last modified:March 8, 2011 - v1
    Checksum:i6B483279C5C4EB83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791L → Q in AAI24597. 1 PublicationCurated
    Sequence conflicti106 – 1061T → N in AAI24597. 1 PublicationCurated
    Sequence conflicti106 – 1061T → N in AAI29041. 1 PublicationCurated
    Sequence conflicti155 – 1551S → N in AAI24597. 1 PublicationCurated
    Sequence conflicti155 – 1551S → N in AAI29041. 1 PublicationCurated
    Sequence conflicti180 – 1801L → F in AAI24597. 1 PublicationCurated
    Sequence conflicti180 – 1801L → F in AAI29041. 1 PublicationCurated
    Sequence conflicti445 – 4451T → M in AAI24597. 1 PublicationCurated
    Sequence conflicti445 – 4451T → M in AAI29041. 1 PublicationCurated
    Sequence conflicti531 – 5311A → V in AAI24597. 1 PublicationCurated
    Sequence conflicti531 – 5311A → V in AAI29041. 1 PublicationCurated
    Sequence conflicti615 – 6151R → K in AAI24597. 1 PublicationCurated
    Sequence conflicti615 – 6151R → K in AAI29041. 1 PublicationCurated
    Sequence conflicti634 – 6341E → V in AAI24597. 1 PublicationCurated
    Sequence conflicti653 – 6531E → EQ in AAI24597. 1 PublicationCurated
    Sequence conflicti654 – 6563LQQ → HHH in AAI29041. 1 PublicationCurated
    Sequence conflicti654 – 6563LQQ → HHH in AAI24597. 1 PublicationCurated
    Sequence conflicti734 – 7341L → P in AAI24597. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT583711 Genomic DNA. No translation available.
    BC124596 mRNA. Translation: AAI24597.1.
    BC129040 mRNA. Translation: AAI29041.1.
    RefSeqiNP_001070811.1. NM_001077343.1.
    UniGeneiDr.150626.

    Genome annotation databases

    EnsembliENSDART00000129632; ENSDARP00000110966; ENSDARG00000040990.
    GeneIDi768201.
    KEGGidre:768201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT583711 Genomic DNA. No translation available.
    BC124596 mRNA. Translation: AAI24597.1 .
    BC129040 mRNA. Translation: AAI29041.1 .
    RefSeqi NP_001070811.1. NM_001077343.1.
    UniGenei Dr.150626.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000076736.

    Protein family/group databases

    MEROPSi C19.053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000129632 ; ENSDARP00000110966 ; ENSDARG00000040990 .
    GeneIDi 768201.
    KEGGi dre:768201.

    Organism-specific databases

    CTDi 57695.
    ZFINi ZDB-GENE-061013-802. usp37.

    Phylogenomic databases

    eggNOGi COG5560.
    GeneTreei ENSGT00440000033542.
    HOGENOMi HOG000060197.
    HOVERGENi HBG055893.
    InParanoidi Q08BR8.
    KOi K11850.

    Miscellaneous databases

    NextBioi 20918515.
    PROi E7F6T8.

    Gene expression databases

    Bgeei E7F6T8.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR003903. Ubiquitin-int_motif.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02809. UIM. 3 hits.
    [Graphical view ]
    SMARTi SM00726. UIM. 3 hits.
    [Graphical view ]
    PROSITEi PS50330. UIM. 2 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiUBP37_DANRE
    AccessioniPrimary (citable) accession number: E7F6T8
    Secondary accession number(s): A1L1F9
    , E7FBK6, F1QUQ3, Q08BR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3