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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

usp37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei331 – 3311NucleophilePROSITE-ProRule annotation
Active sitei866 – 8661Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.046.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:usp37
ORF Names:zgc:152882, zgc:153999
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-061013-802. usp37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412648Add
BLAST

Expressioni

Gene expression databases

BgeeiE7F6T8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076736.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 911590USPAdd
BLAST
Domaini672 – 69120UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini766 – 78520UIM 2PROSITE-ProRule annotationAdd
BLAST
Domaini788 – 80720UIM 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 403KEN box 1By similarity
Motifi76 – 849D-box 1By similarity
Motifi101 – 11010D-box 2By similarity
Motifi162 – 1709D-box 3By similarity
Motifi204 – 2063KEN box 2By similarity
Motifi742 – 7443KEN box 3By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiE7F6T8.
KOiK11850.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7F6T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPRLTS GGAVRIRIRC GELGTTKWRE GVIEIQERDN KINLLVKFNS
60 70 80 90 100
GGAPRVFQLS HNVKSVSWFQ THGPNRMTLT LKDSCIVMMD KLNMLVAKKM
110 120 130 140 150
KEYLETVKLG KPAVFKTNQG SASFGLVLGN RTAQNDSGLS PSDKQSAPRR
160 170 180 190 200
SSLDSREDST PRKPLGSPSR VTSTPARGSL SEIRSEKRKR LMNSDGDLTE
210 220 230 240 250
DYPKENDSSS NNKAITDSSR KFLLSCKDKL KQSEENRASA PHTPAPLQPT
260 270 280 290 300
SFYGSRTGAK DYTQTHSFLD RPSSTGSCPS AKRSLVLPNH STPFKKVRPT
310 320 330 340 350
LDYGGWNKPR PSVLAQPQPP LQGFSNLGNT CYMNAILQSL FSLPSFSNDL
360 370 380 390 400
LKQGIPWKRV PINALLRRFA HLLAKKDISP PEVKKDLLRR VKNAISSTAE
410 420 430 440 450
RFSGYMQNDA HEFLSQCLDQ LKEDVEKINK SWKNEPSAWD EPQSTRLADE
460 470 480 490 500
VDTSRIYTCP VTVNMEFEVQ HTITCKSCGE VVLKREQFND LSIDLPRRRK
510 520 530 540 550
TLPMRSIQDS LDLFFRMEEI EYSCEKCSGK AATVSHKFSR LPRVLILHLK
560 570 580 590 600
RYSYNTQLSL NSKLGQQVLI PKYLTLLSHC TDATRSPLSL GWSAQNALSR
610 620 630 640 650
TLKISQSVNS STLRRASQRP ESSGSVLCDS DSDEELVRKV ARKHHPDDDR
660 670 680 690 700
ADELQQHHPH AAVEQSEFNG INDEEMLAAV LEMSRHDTSL CAGPDEEPSS
710 720 730 740 750
SPDTGFGDAD AHDLTQHLEL LDAEKQPTDA LESLDLTMDE NKENQTPDGL
760 770 780 790 800
QGELDWVQQY SLEQEREEQE LQQALAQSLQ EQEAREMRED DDLKRATELS
810 820 830 840 850
LQEFNNSLPE LLCSDEDSGN EDGLDMEYSE AEAEELKKNA ETGELPNSFR
860 870 880 890 900
LISVVSHIGS SSSSGHYISD VYDMKKQSWL TYNDLDVSRT QESTVQRDRD
910 920 930
RSGYIFFYMH KDVFEELSEL EKAGVNTDGG RTVLQPL
Length:937
Mass (Da):105,264
Last modified:March 8, 2011 - v1
Checksum:i6B483279C5C4EB83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791L → Q in AAI24597 (Ref. 2) Curated
Sequence conflicti106 – 1061T → N in AAI24597 (Ref. 2) Curated
Sequence conflicti106 – 1061T → N in AAI29041 (Ref. 2) Curated
Sequence conflicti155 – 1551S → N in AAI24597 (Ref. 2) Curated
Sequence conflicti155 – 1551S → N in AAI29041 (Ref. 2) Curated
Sequence conflicti180 – 1801L → F in AAI24597 (Ref. 2) Curated
Sequence conflicti180 – 1801L → F in AAI29041 (Ref. 2) Curated
Sequence conflicti445 – 4451T → M in AAI24597 (Ref. 2) Curated
Sequence conflicti445 – 4451T → M in AAI29041 (Ref. 2) Curated
Sequence conflicti531 – 5311A → V in AAI24597 (Ref. 2) Curated
Sequence conflicti531 – 5311A → V in AAI29041 (Ref. 2) Curated
Sequence conflicti615 – 6151R → K in AAI24597 (Ref. 2) Curated
Sequence conflicti615 – 6151R → K in AAI29041 (Ref. 2) Curated
Sequence conflicti634 – 6341E → V in AAI24597 (Ref. 2) Curated
Sequence conflicti653 – 6531E → EQ in AAI24597 (Ref. 2) Curated
Sequence conflicti654 – 6563LQQ → HHH in AAI29041 (Ref. 2) Curated
Sequence conflicti654 – 6563LQQ → HHH in AAI24597 (Ref. 2) Curated
Sequence conflicti734 – 7341L → P in AAI24597 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT583711 Genomic DNA. No translation available.
BC124596 mRNA. Translation: AAI24597.1.
BC129040 mRNA. Translation: AAI29041.1.
RefSeqiNP_001070811.1. NM_001077343.1.
UniGeneiDr.150626.

Genome annotation databases

EnsembliENSDART00000129632; ENSDARP00000110966; ENSDARG00000040990.
GeneIDi768201.
KEGGidre:768201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT583711 Genomic DNA. No translation available.
BC124596 mRNA. Translation: AAI24597.1.
BC129040 mRNA. Translation: AAI29041.1.
RefSeqiNP_001070811.1. NM_001077343.1.
UniGeneiDr.150626.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076736.

Protein family/group databases

MEROPSiC19.046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000129632; ENSDARP00000110966; ENSDARG00000040990.
GeneIDi768201.
KEGGidre:768201.

Organism-specific databases

CTDi57695.
ZFINiZDB-GENE-061013-802. usp37.

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiE7F6T8.
KOiK11850.

Miscellaneous databases

NextBioi20918515.
PROiE7F6T8.

Gene expression databases

BgeeiE7F6T8.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUBP37_DANRE
AccessioniPrimary (citable) accession number: E7F6T8
Secondary accession number(s): A1L1F9
, E7FBK6, F1QUQ3, Q08BR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 8, 2011
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.