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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

usp37

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei331NucleophilePROSITE-ProRule annotation1
Active sitei866Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.046.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:usp37
ORF Names:zgc:152882, zgc:153999
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061013-802. usp37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004126481 – 937Ubiquitin carboxyl-terminal hydrolase 37Add BLAST937

Proteomic databases

PaxDbiE7F6T8.
PeptideAtlasiE7F6T8.

Expressioni

Gene expression databases

BgeeiENSDARG00000040990.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108006.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini322 – 911USPAdd BLAST590
Domaini672 – 691UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini766 – 785UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini788 – 807UIM 3PROSITE-ProRule annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 40KEN box 1By similarity3
Motifi76 – 84D-box 1By similarity9
Motifi101 – 110D-box 2By similarity10
Motifi162 – 170D-box 3By similarity9
Motifi204 – 206KEN box 2By similarity3
Motifi742 – 744KEN box 3By similarity3

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1868. Eukaryota.
ENOG410XP8T. LUCA.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiE7F6T8.
KOiK11850.

Family and domain databases

CDDicd13312. PH_USP37_like. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR003903. UIM_dom.
IPR032069. USP37-like_PH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF16674. UCH_N. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7F6T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPRLTS GGAVRIRIRC GELGTTKWRE GVIEIQERDN KINLLVKFNS
60 70 80 90 100
GGAPRVFQLS HNVKSVSWFQ THGPNRMTLT LKDSCIVMMD KLNMLVAKKM
110 120 130 140 150
KEYLETVKLG KPAVFKTNQG SASFGLVLGN RTAQNDSGLS PSDKQSAPRR
160 170 180 190 200
SSLDSREDST PRKPLGSPSR VTSTPARGSL SEIRSEKRKR LMNSDGDLTE
210 220 230 240 250
DYPKENDSSS NNKAITDSSR KFLLSCKDKL KQSEENRASA PHTPAPLQPT
260 270 280 290 300
SFYGSRTGAK DYTQTHSFLD RPSSTGSCPS AKRSLVLPNH STPFKKVRPT
310 320 330 340 350
LDYGGWNKPR PSVLAQPQPP LQGFSNLGNT CYMNAILQSL FSLPSFSNDL
360 370 380 390 400
LKQGIPWKRV PINALLRRFA HLLAKKDISP PEVKKDLLRR VKNAISSTAE
410 420 430 440 450
RFSGYMQNDA HEFLSQCLDQ LKEDVEKINK SWKNEPSAWD EPQSTRLADE
460 470 480 490 500
VDTSRIYTCP VTVNMEFEVQ HTITCKSCGE VVLKREQFND LSIDLPRRRK
510 520 530 540 550
TLPMRSIQDS LDLFFRMEEI EYSCEKCSGK AATVSHKFSR LPRVLILHLK
560 570 580 590 600
RYSYNTQLSL NSKLGQQVLI PKYLTLLSHC TDATRSPLSL GWSAQNALSR
610 620 630 640 650
TLKISQSVNS STLRRASQRP ESSGSVLCDS DSDEELVRKV ARKHHPDDDR
660 670 680 690 700
ADELQQHHPH AAVEQSEFNG INDEEMLAAV LEMSRHDTSL CAGPDEEPSS
710 720 730 740 750
SPDTGFGDAD AHDLTQHLEL LDAEKQPTDA LESLDLTMDE NKENQTPDGL
760 770 780 790 800
QGELDWVQQY SLEQEREEQE LQQALAQSLQ EQEAREMRED DDLKRATELS
810 820 830 840 850
LQEFNNSLPE LLCSDEDSGN EDGLDMEYSE AEAEELKKNA ETGELPNSFR
860 870 880 890 900
LISVVSHIGS SSSSGHYISD VYDMKKQSWL TYNDLDVSRT QESTVQRDRD
910 920 930
RSGYIFFYMH KDVFEELSEL EKAGVNTDGG RTVLQPL
Length:937
Mass (Da):105,264
Last modified:March 8, 2011 - v1
Checksum:i6B483279C5C4EB83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79L → Q in AAI24597 (Ref. 2) Curated1
Sequence conflicti106T → N in AAI24597 (Ref. 2) Curated1
Sequence conflicti106T → N in AAI29041 (Ref. 2) Curated1
Sequence conflicti155S → N in AAI24597 (Ref. 2) Curated1
Sequence conflicti155S → N in AAI29041 (Ref. 2) Curated1
Sequence conflicti180L → F in AAI24597 (Ref. 2) Curated1
Sequence conflicti180L → F in AAI29041 (Ref. 2) Curated1
Sequence conflicti445T → M in AAI24597 (Ref. 2) Curated1
Sequence conflicti445T → M in AAI29041 (Ref. 2) Curated1
Sequence conflicti531A → V in AAI24597 (Ref. 2) Curated1
Sequence conflicti531A → V in AAI29041 (Ref. 2) Curated1
Sequence conflicti615R → K in AAI24597 (Ref. 2) Curated1
Sequence conflicti615R → K in AAI29041 (Ref. 2) Curated1
Sequence conflicti634E → V in AAI24597 (Ref. 2) Curated1
Sequence conflicti653E → EQ in AAI24597 (Ref. 2) Curated1
Sequence conflicti654 – 656LQQ → HHH in AAI29041 (Ref. 2) Curated3
Sequence conflicti654 – 656LQQ → HHH in AAI24597 (Ref. 2) Curated3
Sequence conflicti734L → P in AAI24597 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT583711 Genomic DNA. No translation available.
BC124596 mRNA. Translation: AAI24597.1.
BC129040 mRNA. Translation: AAI29041.1.
RefSeqiNP_001070811.1. NM_001077343.1.
UniGeneiDr.150626.

Genome annotation databases

GeneIDi768201.
KEGGidre:768201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT583711 Genomic DNA. No translation available.
BC124596 mRNA. Translation: AAI24597.1.
BC129040 mRNA. Translation: AAI29041.1.
RefSeqiNP_001070811.1. NM_001077343.1.
UniGeneiDr.150626.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108006.

Protein family/group databases

MEROPSiC19.046.

Proteomic databases

PaxDbiE7F6T8.
PeptideAtlasiE7F6T8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi768201.
KEGGidre:768201.

Organism-specific databases

CTDi57695.
ZFINiZDB-GENE-061013-802. usp37.

Phylogenomic databases

eggNOGiKOG1868. Eukaryota.
ENOG410XP8T. LUCA.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiE7F6T8.
KOiK11850.

Miscellaneous databases

PROiE7F6T8.

Gene expression databases

BgeeiENSDARG00000040990.

Family and domain databases

CDDicd13312. PH_USP37_like. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR003903. UIM_dom.
IPR032069. USP37-like_PH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF16674. UCH_N. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP37_DANRE
AccessioniPrimary (citable) accession number: E7F6T8
Secondary accession number(s): A1L1F9
, E7FBK6, F1QUQ3, Q08BR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.