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Protein

Tyrosine-protein kinase

Gene

hck

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:hckImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-090313-72. hck.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiE7F0I7.
PRIDEiE7F0I7.

Expressioni

Gene expression databases

BgeeiENSDARG00000058647.
ExpressionAtlasiE7F0I7. baseline.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 112SH3InterPro annotationAdd BLAST61
Domaini117 – 213SH2InterPro annotationAdd BLAST97
Domaini234 – 476Protein kinaseInterPro annotationAdd BLAST243

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
OrthoDBiEOG091G0D46.
TreeFamiTF351634.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

E7F0I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVGTKPEQ DPIGKSVNSD DNRNVAHYTK DPTTGAKANR TTSNAQTPGT
60 70 80 90 100
DTSENIAIAL YDYEAMHEGD LGFKKGDRLR ILQESGEWWK AVIISTGQEG
110 120 130 140 150
FIPSNYVAKD TLETEEWFFK GVSRKDAERQ LLASGNKTGS FMIRDSETTK
160 170 180 190 200
GSYSLSVRDS DHQADTVKHY KIRTLDNGGF YISPRITFNT LQDLVSHYKK
210 220 230 240 250
QSDGLCQSLT SPCLSPKPQK PWEKDAWEIP RESLKLDKRL GAGQFGEVWM
260 270 280 290 300
AMYNKHTKVA VKTMKPGSMS VEAFLMEANL MKSLQHDKLV RLNAVVTKEE
310 320 330 340 350
PIYIITEFME KGSLLDFIKS DEGNRVQLPK LIDFSAQIAE GMAYIEQRNY
360 370 380 390 400
IHRDLRAANI LVNKSLVCKI ADFGLARIIE DNEYTAREGA KFPIKWTAPE
410 420 430 440 450
AINYGSFTIK SDVWSFGILL TEIISYGRTP YPGDCSTVIS YIFHTKIKKK
460 470
GSYAHQNGLV IKNTMNQAIS LYCKLN
Length:476
Mass (Da):53,545
Last modified:January 20, 2016 - v2
Checksum:iEEFB4E29BDB093E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936952 Genomic DNA. No translation available.
CU633736 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000081536; ENSDARP00000075977; ENSDARG00000058647.

Similar proteinsi

Entry informationi

Entry nameiE7F0I7_DANRE
AccessioniPrimary (citable) accession number: E7F0I7
Secondary accession number(s): F1QAU3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: November 22, 2017
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported