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Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 16

Gene

arhgef16

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-193648. NRAGE signals death through JNK.
R-DRE-194840. Rho GTPase cycle.
R-DRE-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 16Imported
Gene namesi
Name:arhgef16Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-081104-446. arhgef16.

PTM / Processingi

Proteomic databases

PaxDbiE7EXP8.

Expressioni

Gene expression databases

BgeeiENSDARG00000077114.
ExpressionAtlasiE7EXP8. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111989.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 435DHInterPro annotationAdd BLAST185
Domaini468 – 575PHInterPro annotationAdd BLAST108
Domaini582 – 642SH3InterPro annotationAdd BLAST61

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00550000074493.
InParanoidiE7EXP8.
OrthoDBiEOG091G01WI.
TreeFamiTF316357.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
cd11938. SH3_ARHGEF16_26. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR035797. ARHGEF16/ARHGEF26_SH3.
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

E7EXP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKSDGST YDQSLLIPES RFNTVLQLDQ SSGKSASSIN LSRLDSPEDE
60 70 80 90 100
RRTVVLSTQS EAARKRGTQQ LIPKSLAVTS RPKNRHHTTV VTLPVPLQAS
110 120 130 140 150
EIGWEDYDSD AGDGVSLRRN RRNKSYRAAI TSLHLDGELQ PESLSPVSDE
160 170 180 190 200
KVVSPKQANK SGRKRTLGRI RNRKHAGSFK DEPRFYQEIK ERGLNVSSLS
210 220 230 240 250
TEEEELSPVG PPGEDQGIVV KNYRAAYITW SQLPQVKDLG ILDFITPEER
260 270 280 290 300
KRQEVIFEII TSEYSYQHSL SILVRHFKDS VDLRKTMTAT EHHHLFSNIS
310 320 330 340 350
VIQDVSKRFF EDLDKRHQAN PVIERISDIV ATYATKHFEP YIVYCSNETF
360 370 380 390 400
QQRTLQKLLS SNSAFRETLK QIETSEDCGG LPMLSFLILP MQRVTRLPLL
410 420 430 440 450
MDTICEKTTK ETAEYYKACW AFKAISKLVK SCNDGARRME RTEQMYTIQK
460 470 480 490 500
QMEFGKIKPF PLVSSSRWLK KSGELAVYTD DLSIFRKAFS FKSYYLFLFN
510 520 530 540 550
DVLIVTKKKS EESYVVLDYA TVEKVEVEEE MSDSKLNLKL MMNPNSDGRS
560 570 580 590 600
EQLVLVAENK LVRAQWVTAL RDVKQTSSID NDDLPQYEAT KAYLPKAPDE
610 620 630 640 650
LSLQQAEVVI VIQEVEGWCY GERMRDGERG WFPASCATQI TNRTAMENNI
660
QRMERLRKET NV
Length:662
Mass (Da):75,870
Last modified:March 8, 2011 - v1
Checksum:iED2192CFFEBBF818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX000472 Genomic DNA. No translation available.
CR792439 Genomic DNA. No translation available.
CT573138 Genomic DNA. No translation available.
RefSeqiXP_005167338.1. XM_005167281.3.
UniGeneiDr.78159.

Genome annotation databases

EnsembliENSDART00000131137; ENSDARP00000111989; ENSDARG00000077114.
GeneIDi567180.

Similar proteinsi

Entry informationi

Entry nameiE7EXP8_DANRE
AccessioniPrimary (citable) accession number: E7EXP8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 22, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported