Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 16

Gene

arhgef16

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-193648 NRAGE signals death through JNK
R-DRE-194840 Rho GTPase cycle
R-DRE-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 16Imported
Gene namesi
Name:arhgef16Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-081104-446 arhgef16

PTM / Processingi

Proteomic databases

PaxDbiE7EXP8

Expressioni

Gene expression databases

BgeeiENSDARG00000077114
ExpressionAtlasiE7EXP8 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111989

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 435DHInterPro annotationAdd BLAST185
Domaini468 – 575PHInterPro annotationAdd BLAST108
Domaini582 – 642SH3InterPro annotationAdd BLAST61

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00550000074493
InParanoidiE7EXP8
OrthoDBiEOG091G01WI
TreeFamiTF316357

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11938 SH3_ARHGEF16_26, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035797 ARHGEF16/ARHGEF26_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

E7EXP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKSDGST YDQSLLIPES RFNTVLQLDQ SSGKSASSIN LSRLDSPEDE
60 70 80 90 100
RRTVVLSTQS EAARKRGTQQ LIPKSLAVTS RPKNRHHTTV VTLPVPLQAS
110 120 130 140 150
EIGWEDYDSD AGDGVSLRRN RRNKSYRAAI TSLHLDGELQ PESLSPVSDE
160 170 180 190 200
KVVSPKQANK SGRKRTLGRI RNRKHAGSFK DEPRFYQEIK ERGLNVSSLS
210 220 230 240 250
TEEEELSPVG PPGEDQGIVV KNYRAAYITW SQLPQVKDLG ILDFITPEER
260 270 280 290 300
KRQEVIFEII TSEYSYQHSL SILVRHFKDS VDLRKTMTAT EHHHLFSNIS
310 320 330 340 350
VIQDVSKRFF EDLDKRHQAN PVIERISDIV ATYATKHFEP YIVYCSNETF
360 370 380 390 400
QQRTLQKLLS SNSAFRETLK QIETSEDCGG LPMLSFLILP MQRVTRLPLL
410 420 430 440 450
MDTICEKTTK ETAEYYKACW AFKAISKLVK SCNDGARRME RTEQMYTIQK
460 470 480 490 500
QMEFGKIKPF PLVSSSRWLK KSGELAVYTD DLSIFRKAFS FKSYYLFLFN
510 520 530 540 550
DVLIVTKKKS EESYVVLDYA TVEKVEVEEE MSDSKLNLKL MMNPNSDGRS
560 570 580 590 600
EQLVLVAENK LVRAQWVTAL RDVKQTSSID NDDLPQYEAT KAYLPKAPDE
610 620 630 640 650
LSLQQAEVVI VIQEVEGWCY GERMRDGERG WFPASCATQI TNRTAMENNI
660
QRMERLRKET NV
Length:662
Mass (Da):75,870
Last modified:March 8, 2011 - v1
Checksum:iED2192CFFEBBF818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX000472 Genomic DNA No translation available.
CR792439 Genomic DNA No translation available.
CT573138 Genomic DNA No translation available.
RefSeqiXP_005167338.1, XM_005167281.3
UniGeneiDr.78159

Genome annotation databases

EnsembliENSDART00000131137; ENSDARP00000111989; ENSDARG00000077114
GeneIDi567180

Similar proteinsi

Entry informationi

Entry nameiE7EXP8_DANRE
AccessioniPrimary (citable) accession number: E7EXP8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health