Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Dynactin subunit 1

Gene

DCTN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Dynactin subunit 1Imported
Gene namesi
Name:DCTN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000204843.12
HGNCiHGNC:2711 DCTN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204843

PTM / Processingi

Proteomic databases

MaxQBiE7EX90
PeptideAtlasiE7EX90
PRIDEiE7EX90

Expressioni

Gene expression databases

BgeeiENSG00000204843
ExpressionAtlasiE7EX90 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiE7EX90, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 73CAP-GlyInterPro annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili200 – 335Sequence analysisAdd BLAST136
Coiled coili343 – 366Sequence analysisAdd BLAST24
Coiled coili371 – 523Sequence analysisAdd BLAST153
Coiled coili935 – 1026Sequence analysisAdd BLAST92
Coiled coili1163 – 1183Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0971 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00760000119173

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR027663 DCTN1
IPR022157 Dynactin
PANTHERiPTHR18916:SF40 PTHR18916:SF40, 1 hit
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF12455 Dynactin, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

E7EX90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEASARPL RVGSRVEVIG KGHRGTVAYV GATLFATGKW VGVILDEAKG
60 70 80 90 100
KNDGTVQGRK YFTCDEGHGI FVRQSQIQVF EDGADTTSPE TPDSSASKVL
110 120 130 140 150
KREGTDTTAK TSKLRGLKPK KAPTARKTTT RRPKPTRPAS TGVAGASSSL
160 170 180 190 200
GPSGSASAGE LSSSEPSTPA QTPLAAPIIP TPVLTSPGAV PPLPSPSKEE
210 220 230 240 250
EGLRAQVRDL EEKLETLRLK RAEDKAKLKE LEKHKIQLEQ VQEWKSKMQE
260 270 280 290 300
QQADLQRRLK EARKEAKEAL EAKERYMEEM ADTADAIEMA TLDKEMAEER
310 320 330 340 350
AESLQQEVEA LKERVDELTT DLEILKAEIE EKGSDGAASS YQLKQLEEQN
360 370 380 390 400
ARLKDALVRM RDLSSSEKQE HVKLQKLMEK KNQELEVVRQ QRERLQEELS
410 420 430 440 450
QAESTIDELK EQVDAALGAE EMVEMLTDRN LNLEEKVREL RETVGDLEAM
460 470 480 490 500
NEMNDELQEN ARETELELRE QLDMAGARVR EAQKRVEAAQ ETVADYQQTI
510 520 530 540 550
KKYRQLTAHL QDVNRELTNQ QEASVERQQQ PPPETFDFKI KFAETKAHAK
560 570 580 590 600
AIEMELRQME VAQANRHMSL LTAFMPDSFL RPGGDHDCVL VLLLMPRLIC
610 620 630 640 650
KAELIRKQAQ EKFELSENCS ERPGLRGAAG EQLSFAAGLV YSLSLLQATL
660 670 680 690 700
HRYEHALSQC SVDVYKKVGS LYPEMSAHER SLDFLIELLH KDQLDETVNV
710 720 730 740 750
EPLTKAIKYY QHLYSIHLAE QPEDCTMQLA DHIKFTQSAL DCMSVEVGRL
760 770 780 790 800
RAFLQGGQEA TDIALLLRDL ETSCSDIRQF CKKIRRRMPG TDAPGIPAAL
810 820 830 840 850
AFGPQVSDTL LDCRKHLTWV VAVLQEVAAA AAQLIAPLAE NEGLLVAALE
860 870 880 890 900
ELAFKASEQI YGTPSSSPYE CLRQSCNILI STMNKLATAM QEGEYDAERP
910 920 930 940 950
PSKPPPVELR AAALRAEITD AEGLGLKLED RETVIKELKK SLKIKGEELS
960 970 980 990 1000
EANVRLSLLE KKLDSAAKDA DERIEKVQTR LEETQALLRK KEKEFEETMD
1010 1020 1030 1040 1050
ALQADIDQLE AEKAELKQRL NSQSKRTIEG LRGPPPSGIA TLVSGIAGGA
1060 1070 1080 1090 1100
IPGQAPGSVP GPGLVKDSPL LLQQISAMRL HISQLQHENS ILKGAQMKAS
1110 1120 1130 1140 1150
LASLPPLHVA KLSHEGPGSE LPAGALYRKT SQLLETLNQL STHTHVVDIT
1160 1170 1180 1190 1200
RTSPAAKSPS AQLMEQVAQL KSLSDTVEKL KDEVLKETVS QRPGATVPTD
1210 1220 1230 1240 1250
FATFPSSAFL RAKEEQQDDT VYMGKVTFSC AAGFGQRHRL VLTQEQLHQL

HSRLIS
Length:1,256
Mass (Da):139,094
Last modified:March 8, 2011 - v1
Checksum:i11FA428428528753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005041 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000409868; ENSP00000387327; ENSG00000204843
ENST00000628224; ENSP00000487279; ENSG00000204843
UCSCiuc061ktk.1 human

Similar proteinsi

Entry informationi

Entry nameiE7EX90_HUMAN
AccessioniPrimary (citable) accession number: E7EX90
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health