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Protein
Submitted name:

Dynactin subunit 1

Gene

DCTN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Dynactin subunit 1Imported
Gene namesi
Name:DCTN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2711. DCTN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE7EX90.
PeptideAtlasiE7EX90.
PRIDEiE7EX90.

Expressioni

Gene expression databases

BgeeiENSG00000204843.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354791.

Structurei

3D structure databases

SMRiE7EX90. Positions 8-81, 421-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 7343CAP-GlyInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili200 – 335136Sequence analysisAdd
BLAST
Coiled coili343 – 36624Sequence analysisAdd
BLAST
Coiled coili371 – 523153Sequence analysisAdd
BLAST
Coiled coili935 – 102692Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0971. Eukaryota.
COG5244. LUCA.
GeneTreeiENSGT00760000119173.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR027663. DCTN1.
IPR022157. Dynactin.
[Graphical view]
PANTHERiPTHR18916:SF40. PTHR18916:SF40. 1 hit.
PfamiPF01302. CAP_GLY. 1 hit.
PF12455. Dynactin. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EX90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEASARPL RVGSRVEVIG KGHRGTVAYV GATLFATGKW VGVILDEAKG
60 70 80 90 100
KNDGTVQGRK YFTCDEGHGI FVRQSQIQVF EDGADTTSPE TPDSSASKVL
110 120 130 140 150
KREGTDTTAK TSKLRGLKPK KAPTARKTTT RRPKPTRPAS TGVAGASSSL
160 170 180 190 200
GPSGSASAGE LSSSEPSTPA QTPLAAPIIP TPVLTSPGAV PPLPSPSKEE
210 220 230 240 250
EGLRAQVRDL EEKLETLRLK RAEDKAKLKE LEKHKIQLEQ VQEWKSKMQE
260 270 280 290 300
QQADLQRRLK EARKEAKEAL EAKERYMEEM ADTADAIEMA TLDKEMAEER
310 320 330 340 350
AESLQQEVEA LKERVDELTT DLEILKAEIE EKGSDGAASS YQLKQLEEQN
360 370 380 390 400
ARLKDALVRM RDLSSSEKQE HVKLQKLMEK KNQELEVVRQ QRERLQEELS
410 420 430 440 450
QAESTIDELK EQVDAALGAE EMVEMLTDRN LNLEEKVREL RETVGDLEAM
460 470 480 490 500
NEMNDELQEN ARETELELRE QLDMAGARVR EAQKRVEAAQ ETVADYQQTI
510 520 530 540 550
KKYRQLTAHL QDVNRELTNQ QEASVERQQQ PPPETFDFKI KFAETKAHAK
560 570 580 590 600
AIEMELRQME VAQANRHMSL LTAFMPDSFL RPGGDHDCVL VLLLMPRLIC
610 620 630 640 650
KAELIRKQAQ EKFELSENCS ERPGLRGAAG EQLSFAAGLV YSLSLLQATL
660 670 680 690 700
HRYEHALSQC SVDVYKKVGS LYPEMSAHER SLDFLIELLH KDQLDETVNV
710 720 730 740 750
EPLTKAIKYY QHLYSIHLAE QPEDCTMQLA DHIKFTQSAL DCMSVEVGRL
760 770 780 790 800
RAFLQGGQEA TDIALLLRDL ETSCSDIRQF CKKIRRRMPG TDAPGIPAAL
810 820 830 840 850
AFGPQVSDTL LDCRKHLTWV VAVLQEVAAA AAQLIAPLAE NEGLLVAALE
860 870 880 890 900
ELAFKASEQI YGTPSSSPYE CLRQSCNILI STMNKLATAM QEGEYDAERP
910 920 930 940 950
PSKPPPVELR AAALRAEITD AEGLGLKLED RETVIKELKK SLKIKGEELS
960 970 980 990 1000
EANVRLSLLE KKLDSAAKDA DERIEKVQTR LEETQALLRK KEKEFEETMD
1010 1020 1030 1040 1050
ALQADIDQLE AEKAELKQRL NSQSKRTIEG LRGPPPSGIA TLVSGIAGGA
1060 1070 1080 1090 1100
IPGQAPGSVP GPGLVKDSPL LLQQISAMRL HISQLQHENS ILKGAQMKAS
1110 1120 1130 1140 1150
LASLPPLHVA KLSHEGPGSE LPAGALYRKT SQLLETLNQL STHTHVVDIT
1160 1170 1180 1190 1200
RTSPAAKSPS AQLMEQVAQL KSLSDTVEKL KDEVLKETVS QRPGATVPTD
1210 1220 1230 1240 1250
FATFPSSAFL RAKEEQQDDT VYMGKVTFSC AAGFGQRHRL VLTQEQLHQL

HSRLIS
Length:1,256
Mass (Da):139,094
Last modified:March 8, 2011 - v1
Checksum:i11FA428428528753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005041 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000409868; ENSP00000387327; ENSG00000204843.
ENST00000628224; ENSP00000487279; ENSG00000204843.
UCSCiuc061ktk.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005041 Genomic DNA. No translation available.

3D structure databases

SMRiE7EX90. Positions 8-81, 421-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354791.

Proteomic databases

EPDiE7EX90.
PeptideAtlasiE7EX90.
PRIDEiE7EX90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409868; ENSP00000387327; ENSG00000204843.
ENST00000628224; ENSP00000487279; ENSG00000204843.
UCSCiuc061ktk.1. human.

Organism-specific databases

HGNCiHGNC:2711. DCTN1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0971. Eukaryota.
COG5244. LUCA.
GeneTreeiENSGT00760000119173.

Miscellaneous databases

ChiTaRSiDCTN1. human.

Gene expression databases

BgeeiENSG00000204843.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR027663. DCTN1.
IPR022157. Dynactin.
[Graphical view]
PANTHERiPTHR18916:SF40. PTHR18916:SF40. 1 hit.
PfamiPF01302. CAP_GLY. 1 hit.
PF12455. Dynactin. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7EX90_HUMAN
AccessioniPrimary (citable) accession number: E7EX90
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.