SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E7EX88

- E7EX88_HUMAN

UniProt

E7EX88 - E7EX88_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Aggrecan core protein

Gene
ACAN
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronic acid binding Source: InterPro

GO - Biological processi

  1. cartilage condensation Source: Ensembl
  2. chondrocyte development Source: Ensembl
  3. collagen fibril organization Source: Ensembl
  4. proteoglycan biosynthetic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Aggrecan core proteinImported
Gene namesi
Name:ACANImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:319. ACAN.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE7EX88.
SMRiE7EX88. Positions 2318-2443.

Family & Domainsi

Sequence similaritiesi

Contains C-type lectin domain.SAAS annotations

Keywords - Domaini

EGF-like domainSAAS annotations, Immunoglobulin domainSAAS annotations, RepeatSAAS annotations, SushiSAAS annotations

Phylogenomic databases

KOiK06792.
OMAiCESHNAT.
PhylomeDBiE7EX88.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 5 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 4 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00445. LINK. 4 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 5 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 4 hits.
PS50963. LINK_2. 4 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EX88-1 [UniParc]FASTAAdd to Basket

« Hide

MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP     50
CYFIDPMHPV TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY 100
QDKVSLPNYP AIPSDATLEV QSLRSNDSGV YRCEVMHGIE DSEATLEVVV 150
KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD 200
AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE 250
MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG 300
WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT 350
GEDFVDIPEN FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT 400
VKPIFEVSPS PLEPEEPFTF APEIGATAFA EVENETGEAT RPWGFPTPGL 450
GPATAFTSED LVVQVTAVPG QPHLPGGVVF HYRPGPTRYS LTFEEAQQAC 500
LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS PRTPCVGDKD 550
SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES 600
HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV 650
RTVYLYPNQT GLPDPLSRHH AFCFRGISAV PSPGEEEGGT PTSPSGVEEW 700
IVTQVVPGVA AVPVEEETTA VPSGETTAIL EFTTEPENQT EWEPAYTPVG 750
TSPLPGILPT WPPTGAATEE STEGPSATEV PSASEEPSPS EVPFPSEEPS 800
PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE PYTPSPPVPS 850
WTELPSSGEE SGAPDVSGDF TGSGDVSGHL DFSGQLSGDR ASGLPSGDLD 900
SSGLTSTVGS GLPVESGLPS GDEERIEWPS TPTVGELPSG AEILEGSASG 950
VGDLSGLPSG EVLETSASGV GDLSGLPSGE VLETTAPGVE DISGLPSGEV 1000
LETTAPGVED ISGLPSGEVL ETTAPGVEDI SGLPSGEVLE TTAPGVEDIS 1050
GLPSGEVLET TAPGVEDISG LPSGEVLETT APGVEDISGL PSGEVLETAA 1100
PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG 1150
EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED 1200
ISGLPSGEVL ETAAPGVEDI SGLPSGEVLE TAAPGVEDIS GLPSGEVLET 1250
AAPGVEDISG LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP 1300
SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG EVLETAAPGV 1350
EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED ISGLPSGEVL 1400
ETTAPGVEEI SGLPSGEVLE TTAPGVDEIS GLPSGEVLET TAPGVEEISG 1450
LPSGEVLETS TSAVGDLSGL PSGGEVLEIS VSGVEDISGL PSGEVVETSA 1500
SGIEDVSELP SGEGLETSAS GVEDLSRLPS GEEVLEISAS GFGDLSGLPS 1550
GGEGLETSAS EVGTDLSGLP SGREGLETSA SGAEDLSGLP SGKEDLVGSA 1600
SGDLDLGKLP SGTLGSGQAP ETSGLPSGFS GEYSGVDLGS GPPSGLPDFS 1650
GLPSGFPTVS LVDSTLVEVV TASTASELEG RGTIGISGAG EISGLPSSEL 1700
DISGRASGLP SGTELSGQAS GSPDVSGEIP GLFGVSGQPS GFPDTSGETS 1750
GVTELSGLSS GQPGISGEAS GVLYGTSQPF GITDLSGETS GVPDLSGQPS 1800
GLPGFSGATS GVPDLVSGTT SGSGESSGIT FVDTSLVEVA PTTFKEEEGL 1850
GSVELSGLPS GEADLSGKSG MVDVSGQFSG TVDSSGFTSQ TPEFSGLPSG 1900
IAEVSGESSR AEIGSSLPSG AYYGSGTPSS FPTVSLVDRT LVESVTQAPT 1950
AQEAGEGPSG ILELSGAHSG APDMSGEHSG FLDLSGLQSG LIEPSGEPPG 2000
TPYFSGDFAS TTNVSGESSV AMGTSGEASG LPEVTLITSE FVEGVTEPTI 2050
SQELGQRPPV THTPQLFESS GKVSTAGDIS GATPVLPGSG VEVSSVPESS 2100
SETSAYPEAG FGASAAPEAS REDSGSPDLS ETTSAFHEAN LERSSGLGVS 2150
GSTLTFQEGE ASAAPEVSGE STTTSDVGTE APGLPSATPT ASGDRTEISG 2200
DLSGHTSQLG VVISTSIPES EWTQQTQRPA ETHLEIESSS LLYSGEETHT 2250
VETATSPTDA SIPASPEWKR ESESTAAAPA RSCAEEPCGA GTCKETEGHV 2300
ICLCPPGYTG EHCNIDQEVC EEGWNKYQGH CYRHFPDRET WVDAERRCRE 2350
QQSHLSSIVT PEEQEFVNNN AQDYQWIGLN DRTIEGDFRW SDGHPMQFEN 2400
WRPNQPDNFF AAGEDCVVMI WHEKGEWNDV PCNYHLPFTC KKGTVACGEP 2450
PVVEHARTFG QKKDRYEINS LVRYQCTEGF VQRHMPTIRC QPSGHWEEPQ 2500
ITCTDPTTYK RRLQKRSSRH PRRSRPSTAH 2530
Length:2,530
Mass (Da):261,329
Last modified:June 28, 2011 - v2
Checksum:i3C809F6DE829956B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC103982 Genomic DNA. No translation available.
RefSeqiNP_037359.3. NM_013227.3.
UniGeneiHs.2159.
Hs.616395.

Genome annotation databases

EnsembliENST00000439576; ENSP00000387356; ENSG00000157766.
ENST00000561243; ENSP00000453342; ENSG00000157766.
GeneIDi176.
KEGGihsa:176.
UCSCiuc010upo.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC103982 Genomic DNA. No translation available.
RefSeqi NP_037359.3. NM_013227.3.
UniGenei Hs.2159.
Hs.616395.

3D structure databases

ProteinModelPortali E7EX88.
SMRi E7EX88. Positions 2318-2443.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000439576 ; ENSP00000387356 ; ENSG00000157766 .
ENST00000561243 ; ENSP00000453342 ; ENSG00000157766 .
GeneIDi 176.
KEGGi hsa:176.
UCSCi uc010upo.1. human.

Organism-specific databases

CTDi 176.
HGNCi HGNC:319. ACAN.
GenAtlasi Search...

Phylogenomic databases

KOi K06792.
OMAi CESHNAT.
PhylomeDBi E7EX88.
TreeFami TF332134.

Miscellaneous databases

ChiTaRSi ACAN. human.
GenomeRNAii 176.
NextBioi 706.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 5 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 4 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00445. LINK. 4 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 5 hits.
SSF57535. SSF57535. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 4 hits.
PS50963. LINK_2. 4 hits.
PS50923. SUSHI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7EX88_HUMAN
AccessioniPrimary (citable) accession number: E7EX88
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi