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Protein
Submitted name:

Eukaryotic translation initiation factor 4B

Gene

EIF4B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4BImported
Gene namesi
Name:EIF4BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:3285. EIF4B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000063046.

PTM / Processingi

Proteomic databases

EPDiE7EX17.
MaxQBiE7EX17.
PaxDbiE7EX17.
PeptideAtlasiE7EX17.
PRIDEiE7EX17.

Expressioni

Gene expression databases

BgeeiENSG00000063046.
ExpressionAtlasiE7EX17. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262056.

Structurei

3D structure databases

ProteinModelPortaliE7EX17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 173RRM (RNA recognition motif)InterPro annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili370 – 397Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
ENOG4111NS2. LUCA.
GeneTreeiENSGT00530000063406.
OMAiPSWRTEE.
OrthoDBiEOG091G0DWC.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR033107. EIF4B.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR23236:SF2. PTHR23236:SF2. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EX17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD
60 70 80 90 100
VSTTWHSNDD DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL
110 120 130 140 150
GNLPYDVTEE SIKEFFRGLN ISAVRLPREP SNPERLKGFG YAEFEDLDSL
160 170 180 190 200
LSALSLNEES LGNRRIRVDV ADQAQDKDRD DRSFGRDRNR DSDKTDTDWR
210 220 230 240 250
ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG YRDGPRRDMD
260 270 280 290 300
RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED
310 320 330 340 350
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS
360 370 380 390 400
TSQSTRAASI FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP
410 420 430 440 450
RERHPSWRSE ETQERERSRT GSESSQTGTS TTSSRSKSDQ DARRRESEKS
460 470 480 490 500
LENETLNKEE DCHSPTSKPP KPDQPLKVMP APPPKENAWV KRSSNPPARS
510 520 530 540 550
QSSDTEQQSP TSGGGKVAPA QPSEEGPGRK DENKVDGMNA PKGQTGNSSR
560 570 580 590 600
GPGDGGNRDH WKESDRKDGK KDQDSRSAPE PKKPEENPAS KFSSASKYAA
610
LSVDGEDENE GEDYAE
Length:616
Mass (Da):69,698
Last modified:March 8, 2011 - v1
Checksum:i0F133C6134D04FA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068888 Genomic DNA. No translation available.
RefSeqiNP_001287750.1. NM_001300821.2.
UniGeneiHs.648394.
Hs.702041.

Genome annotation databases

EnsembliENST00000420463; ENSP00000388806; ENSG00000063046.
GeneIDi1975.
UCSCiuc010snu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068888 Genomic DNA. No translation available.
RefSeqiNP_001287750.1. NM_001300821.2.
UniGeneiHs.648394.
Hs.702041.

3D structure databases

ProteinModelPortaliE7EX17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262056.

Proteomic databases

EPDiE7EX17.
MaxQBiE7EX17.
PaxDbiE7EX17.
PeptideAtlasiE7EX17.
PRIDEiE7EX17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420463; ENSP00000388806; ENSG00000063046.
GeneIDi1975.
UCSCiuc010snu.3. human.

Organism-specific databases

CTDi1975.
HGNCiHGNC:3285. EIF4B.
OpenTargetsiENSG00000063046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
ENOG4111NS2. LUCA.
GeneTreeiENSGT00530000063406.
OMAiPSWRTEE.
OrthoDBiEOG091G0DWC.

Miscellaneous databases

ChiTaRSiEIF4B. human.
GenomeRNAii1975.

Gene expression databases

BgeeiENSG00000063046.
ExpressionAtlasiE7EX17. baseline and differential.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR033107. EIF4B.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR23236:SF2. PTHR23236:SF2. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7EX17_HUMAN
AccessioniPrimary (citable) accession number: E7EX17
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.