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E7EWP8

- E7EWP8_HUMAN

UniProt

E7EWP8 - E7EWP8_HUMAN

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Protein
Submitted name:

Cyclic AMP-responsive element-binding protein 1

Gene

CREB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. axonogenesis Source: Ensembl
  2. cellular response to growth factor stimulus Source: Ensembl
  3. cellular response to zinc ion Source: Ensembl
  4. circadian rhythm Source: Ensembl
  5. lactation Source: Ensembl
  6. lung saccule development Source: Ensembl
  7. memory Source: Ensembl
  8. pituitary gland development Source: Ensembl
  9. positive regulation of fat cell differentiation Source: Ensembl
  10. positive regulation of hormone secretion Source: Ensembl
  11. positive regulation of lipid biosynthetic process Source: Ensembl
  12. positive regulation of multicellular organism growth Source: Ensembl
  13. positive regulation of osteoclast differentiation Source: Ensembl
  14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. protein stabilization Source: Ensembl
  16. regulation of cell size Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to glucagon Source: Ensembl
  19. secretory granule organization Source: Ensembl
  20. Type I pneumocyte differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclic AMP-responsive element-binding protein 1Imported
Gene namesi
Name:CREB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2345. CREB1.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE7EWP8.
ExpressionAtlasiE7EWP8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7EWP8.
SMRiE7EWP8. Positions 119-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000008655.

Family and domain databases

InterProiIPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
PROSITEiPS50953. KID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E7EWP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA
60 70 80 90 100
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT
110 120 130 140 150
QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR
160 170 180
IEEEKSEEET SAPAITTVTV PTPIYQTSSG QY
Length:182
Mass (Da):19,485
Last modified:March 8, 2011 - v1
Checksum:i869266E2C387A018
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei182 – 1821Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009298 Genomic DNA. No translation available.
AC079767 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000445803; ENSP00000407227; ENSG00000118260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009298 Genomic DNA. No translation available.
AC079767 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E7EWP8.
SMRi E7EWP8. Positions 119-146.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000445803 ; ENSP00000407227 ; ENSG00000118260 .

Organism-specific databases

HGNCi HGNC:2345. CREB1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000008655.

Miscellaneous databases

NextBioi 35500835.

Gene expression databases

Bgeei E7EWP8.
ExpressionAtlasi E7EWP8. baseline and differential.

Family and domain databases

InterProi IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
PROSITEi PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7EWP8_HUMAN
AccessioniPrimary (citable) accession number: E7EWP8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3