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E7EWP8

- E7EWP8_HUMAN

UniProt

E7EWP8 - E7EWP8_HUMAN

Protein
Submitted name:

Cyclic AMP-responsive element-binding protein 1

Gene

CREB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. axonogenesis Source: Ensembl
    2. cellular response to growth factor stimulus Source: Ensembl
    3. lactation Source: Ensembl
    4. lung saccule development Source: Ensembl
    5. pituitary gland development Source: Ensembl
    6. positive regulation of fat cell differentiation Source: Ensembl
    7. positive regulation of hormone secretion Source: Ensembl
    8. positive regulation of lipid biosynthetic process Source: Ensembl
    9. positive regulation of multicellular organism growth Source: Ensembl
    10. positive regulation of osteoclast differentiation Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. protein stabilization Source: Ensembl
    13. regulation of cell size Source: Ensembl
    14. response to drug Source: Ensembl
    15. secretory granule organization Source: Ensembl
    16. Type I pneumocyte differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cyclic AMP-responsive element-binding protein 1Imported
    Gene namesi
    Name:CREB1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:2345. CREB1.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. transcription factor complex Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiE7EWP8.
    BgeeiE7EWP8.

    Structurei

    3D structure databases

    ProteinModelPortaliE7EWP8.
    SMRiE7EWP8. Positions 119-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view]
    PfamiPF02173. pKID. 1 hit.
    [Graphical view]
    PRINTSiPR00041. LEUZIPPRCREB.
    PROSITEiPS50953. KID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E7EWP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA    50
    PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT 100
    QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR 150
    IEEEKSEEET SAPAITTVTV PTPIYQTSSG QY 182
    Length:182
    Mass (Da):19,485
    Last modified:March 8, 2011 - v1
    Checksum:i869266E2C387A018
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei182 – 1821Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009298 Genomic DNA. No translation available.
    AC079767 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000445803; ENSP00000407227; ENSG00000118260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009298 Genomic DNA. No translation available.
    AC079767 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E7EWP8.
    SMRi E7EWP8. Positions 119-146.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000445803 ; ENSP00000407227 ; ENSG00000118260 .

    Organism-specific databases

    HGNCi HGNC:2345. CREB1.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35500835.

    Gene expression databases

    ArrayExpressi E7EWP8.
    Bgeei E7EWP8.

    Family and domain databases

    InterProi IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view ]
    Pfami PF02173. pKID. 1 hit.
    [Graphical view ]
    PRINTSi PR00041. LEUZIPPRCREB.
    PROSITEi PS50953. KID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7EWP8_HUMAN
    AccessioniPrimary (citable) accession number: E7EWP8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3