Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Adhesion G protein-coupled receptor E3

Gene

ADGRE3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor E3Imported
Gene namesi
Name:ADGRE3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000131355.14.
HGNCiHGNC:23647. ADGRE3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei232 – 255HelicalSequence analysisAdd BLAST24
Transmembranei267 – 284HelicalSequence analysisAdd BLAST18
Transmembranei296 – 320HelicalSequence analysisAdd BLAST25
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei380 – 404HelicalSequence analysisAdd BLAST25
Transmembranei424 – 446HelicalSequence analysisAdd BLAST23
Transmembranei452 – 475HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500321736123 – 526Sequence analysisAdd BLAST504

Proteomic databases

PaxDbiE7EW83.
PeptideAtlasiE7EW83.

Expressioni

Gene expression databases

BgeeiENSG00000131355.
ExpressionAtlasiE7EW83. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7EW83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 224GPSInterPro annotationAdd BLAST50
Domaini230 – 476G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00900000140800.

Family and domain databases

InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00303. GPS. 1 hit.
PROSITEiView protein in PROSITE
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.

Sequencei

Sequence statusi: Complete.

E7EW83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT
60 70 80 90 100
SGSGQKLFTF PLETCNAIET QAITDNCSEE RKTFNLNVQM NSMDIRCSDI
110 120 130 140 150
IQGDTQGPSA IAFISYSSLG NIINATFFEE MDKKDQVYLN SQVVSAAIGP
160 170 180 190 200
KRNVSLSKSV TLTFQHVKMT PSTKKVFCVY WKSTGQGSQW SRDGCFLIHV
210 220 230 240 250
NKSHTMCNCS HLSSFAVLMA LTSQEEDPVL TVITYVGLSV SLLCLLLAAL
260 270 280 290 300
TFLLCKAIRN TSTSLHLQLS LCLFLAHLLF LVGIDRTEPK VLCSIIAGAL
310 320 330 340 350
HYLYLAAFTW MLLEGVHLFL TARNLTVVNY SSINRLMKWI MFPVGYGVPA
360 370 380 390 400
VTVAISAASW PHLYGTADRC WLHLDQGFMW SFLGPVCAIF SANLVLFILV
410 420 430 440 450
FWILKRKLSS LNSEVSTIQN TRMLAFKATA QLFILGCTWC LGLLQVGPAA
460 470 480 490 500
QVMAYLFTII NSLQGFFIFL VYCLLSQQVQ KQYQKWFREI VKSKSESETY
510 520
TLSSKMGPDS KPSEGDVFPG QVKRKY
Length:526
Mass (Da):58,396
Last modified:June 28, 2011 - v2
Checksum:i1C6B358A321BE750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022149 Genomic DNA. No translation available.
AC090427 Genomic DNA. No translation available.
AC135052 Genomic DNA. No translation available.
RefSeqiNP_001276088.1. NM_001289159.1.
UniGeneiHs.658712.

Genome annotation databases

EnsembliENST00000443157; ENSP00000396208; ENSG00000131355.
GeneIDi84658.
UCSCiuc010xnv.4. human.

Similar proteinsi

Entry informationi

Entry nameiE7EW83_HUMAN
AccessioniPrimary (citable) accession number: E7EW83
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported