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Protein
Submitted name:

Alpha-1A adrenergic receptor

Gene

ADRA1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-1A adrenergic receptorImported
Gene namesi
Name:ADRA1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000120907.17
HGNCiHGNC:277 ADRA1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 52HelicalSequence analysisAdd BLAST27
Transmembranei64 – 94HelicalSequence analysisAdd BLAST31
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Transmembranei143 – 164HelicalSequence analysisAdd BLAST22
Transmembranei184 – 209HelicalSequence analysisAdd BLAST26
Transmembranei273 – 298HelicalSequence analysisAdd BLAST26
Transmembranei310 – 328HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120907

PTM / Processingi

Proteomic databases

PRIDEiE7EW16

Expressioni

Gene expression databases

BgeeiENSG00000120907
ExpressionAtlasiE7EW16 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EW16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 326G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST284

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001004 ADRA1A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00557 ADRENRGCA1AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

E7EW16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV
160 170 180 190 200
WALSLVISIG PLFGWRQPAP EDETICQINE EPGYVLFSAL GSFYLPLAII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN APAGGSGMAS
260 270 280 290 300
AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
310 320 330 340 350
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ
360 370 380 390 400
SSKHALGYTL HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF
410 420
SSMPRGSARI TVSKDQSSCT TARSSGF
Length:427
Mass (Da):47,215
Last modified:March 8, 2011 - v1
Checksum:iB70C0E2B4687FA2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015564 Genomic DNA No translation available.
AC022839 Genomic DNA No translation available.
AC091675 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000519229; ENSP00000430793; ENSG00000120907
UCSCiuc064lkb.1 human

Similar proteinsi

Entry informationi

Entry nameiE7EW16_HUMAN
AccessioniPrimary (citable) accession number: E7EW16
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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