ID E7EVZ9_HUMAN Unreviewed; 166 AA. AC E7EVZ9; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 27-MAR-2024, entry version 84. DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633}; DE Flags: Fragment; GN Name=ITGB2 {ECO:0000313|Ensembl:ENSP00000428503.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428503.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000428503.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10830953; DOI=10.1038/35012518; RG Chromosome 21 mapping and sequencing consortium; RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U., RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.; RT "The DNA sequence of human chromosome 21."; RL Nature 405:311-319(2000). RN [2] {ECO:0007829|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000428503.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251, CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}. CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the integrin beta chain family. CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL773603; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844908; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877928; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E7EVZ9; -. DR SMR; E7EVZ9; -. DR MassIVE; E7EVZ9; -. DR MaxQB; E7EVZ9; -. DR PeptideAtlas; E7EVZ9; -. DR ProteomicsDB; 18737; -. DR Antibodypedia; 1501; 2205 antibodies from 50 providers. DR Ensembl; ENST00000523663.5; ENSP00000428503.1; ENSG00000160255.19. DR UCSC; uc062aue.1; human. DR HGNC; HGNC:6155; ITGB2. DR VEuPathDB; HostDB:ENSG00000160255; -. DR GeneTree; ENSGT01090000259987; -. DR OMA; TNCECQC; -. DR ChiTaRS; ITGB2; human. DR Proteomes; UP000005640; Chromosome 21. DR Bgee; ENSG00000160255; Expressed in granulocyte and 164 other cell types or tissues. DR ExpressionAtlas; E7EVZ9; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0043235; C:receptor complex; IEA:UniProt. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 6.20.50.10; -; 1. DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1. DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1. DR InterPro; IPR015439; Integrin_b-2_sf. DR InterPro; IPR033760; Integrin_beta_N. DR InterPro; IPR015812; Integrin_bsu. DR InterPro; IPR002369; Integrin_bsu_VWA. DR InterPro; IPR016201; PSI. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1. DR PANTHER; PTHR10082:SF15; INTEGRIN BETA-2; 1. DR Pfam; PF00362; Integrin_beta; 1. DR Pfam; PF17205; PSI_integrin; 1. DR PRINTS; PR01186; INTEGRINB. DR SMART; SM00187; INB; 1. DR SMART; SM00423; PSI; 1. DR SUPFAM; SSF103575; Plexin repeat; 1. DR SUPFAM; SSF53300; vWA-like; 1. DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1. PE 1: Evidence at protein level; KW Cell adhesion {ECO:0000256|RuleBase:RU000633}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Proteomics identification {ECO:0007829|EPD:E7EVZ9, KW ECO:0007829|MaxQB:E7EVZ9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000633}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..166 FT /note="Integrin beta" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003219027" FT DOMAIN 24..74 FT /note="PSI" FT /evidence="ECO:0000259|SMART:SM00423" FT DOMAIN 32..166 FT /note="Integrin beta subunit VWA" FT /evidence="ECO:0000259|SMART:SM00187" FT NON_TER 166 FT /evidence="ECO:0000313|Ensembl:ENSP00000428503.1" SQ SEQUENCE 166 AA; 18288 MW; 74B92D6DE99BB7D3 CRC64; MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRI //