ID   E7EVG6_HUMAN            Unreviewed;      1400 AA.
AC   E7EVG6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=PPARG related coactivator 1 {ECO:0000313|Ensembl:ENSP00000399743.2};
GN   Name=PPRC1 {ECO:0000313|Ensembl:ENSP00000399743.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399743.2, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000399743.2, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0007829|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [3] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [4] {ECO:0000313|Ensembl:ENSP00000399743.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AL500527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001275656.1; NM_001288727.1.
DR   SMR; E7EVG6; -.
DR   IntAct; E7EVG6; 1.
DR   MassIVE; E7EVG6; -.
DR   MaxQB; E7EVG6; -.
DR   PeptideAtlas; E7EVG6; -.
DR   ProteomicsDB; 18636; -.
DR   Antibodypedia; 48608; 142 antibodies from 25 providers.
DR   DNASU; 23082; -.
DR   Ensembl; ENST00000413464.6; ENSP00000399743.2; ENSG00000148840.11.
DR   GeneID; 23082; -.
DR   UCSC; uc010qqj.4; human.
DR   CTD; 23082; -.
DR   HGNC; HGNC:30025; PPRC1.
DR   VEuPathDB; HostDB:ENSG00000148840; -.
DR   GeneTree; ENSGT00950000183137; -.
DR   OrthoDB; 3134278at2759; -.
DR   BioGRID-ORCS; 23082; 422 hits in 1175 CRISPR screens.
DR   ChiTaRS; PPRC1; human.
DR   GenomeRNAi; 23082; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000148840; Expressed in left uterine tube and 178 other cell types or tissues.
DR   ExpressionAtlas; E7EVG6; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   CDD; cd12624; RRM_PRC; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR034605; PGC-1.
DR   InterPro; IPR034834; PRC_RRM.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR15528; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED; 1.
DR   PANTHER; PTHR15528:SF5; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-RELATED PROTEIN 1; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:E7EVG6,
KW   ECO:0007829|MaxQB:E7EVG6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          1279..1355
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1045..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1092..1131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1183..1270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..510
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        750..767
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        824..838
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1094..1113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1198..1239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1254..1270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1400 AA;  149191 MW;  E56CC8412EFF8A6E CRC64;
     MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE QVLLHEEAGD
     SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA SLISLIEDFG SLGESRLSLE
     DQNEVSLLTA LTEILDNADS ENLSPFDSIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI
     TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP
     QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE
     SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE
     IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE
     KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR
     SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL
     ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV
     LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP
     SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK
     TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP
     SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA
     SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP
     SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS
     VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG
     TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK
     ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL
     RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG
     NSGSSCSSSG RSRRCSSSSS SSSSSSSSSS SSSSSRSRSR SPSPRRRSDR RRRYSSYRSH
     DHYQRQRVLQ KERAIEERRV VFIGKIPGRM TRSELKQRFS VFGEIEECTI HFRVQGDNYG
     FVTYRYAEEA FAAIESGHKL RQADEQPFDL CFGGRRQFCK RSYSDLDSNR EDFDPAPVKS
     KFDSLDFDTL LKQAQKNLRR
//