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Protein
Submitted name:

Proline-, glutamic acid- and leucine-rich protein 1

Gene

PELP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Proline-, glutamic acid- and leucine-rich protein 1Imported
Gene namesi
Name:PELP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30134. PELP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE7EV54.
PaxDbiE7EV54.
PRIDEiE7EV54.

Expressioni

Gene expression databases

BgeeiE7EV54.
ExpressionAtlasiE7EV54. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301396.

Structurei

3D structure databases

ProteinModelPortaliE7EV54.
SMRiE7EV54. Positions 69-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180RIX1InterPro annotationAdd
BLAST
Domaini276 – 34166NUC202InterPro annotationAdd
BLAST
Domaini422 – 49271NUC202InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili734 – 81683Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ4S. Eukaryota.
ENOG4110K7C. LUCA.
GeneTreeiENSGT00730000111225.
KOiK16913.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR012583. RIX1_N.
IPR012980. Uncharacterised_NUC202.
[Graphical view]
PfamiPF08166. NUC202. 2 hits.
PF08167. RIX1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

E7EV54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAVAVLRD LLRYAAQLPA LFRDISMNHL PGLLTSLLGL RPECEQSALE
60 70 80 90 100
GMKACMTYFP RACGSLKGKL ASFFLSRVDA LSPQLQQLAC ECYSRLPSLG
110 120 130 140 150
AGFSQGLKHT ESWEQELHSL LASLHTLLGA LYEGAETAPV QNEGPGVEML
160 170 180 190 200
LSSEDGDAHV LLQLRQRFSG LARCLGLMLS SEFGAPVSVP VQEILDFICR
210 220 230 240 250
TLSVSSKNIS LHGDGPLRLL LLPSIHLEAL DLLSALILAC GSRLLRFGIL
260 270 280 290 300
IGRLLPQVLN SWSIGRDSLS PGQERPYSTV RTKVYAILEL WVQVCGASAG
310 320 330 340 350
MLQGGASGEA LLTHLLSDIS PPADALKLRS PRGSPDGSLQ TGKPSAPKKL
360 370 380 390 400
KLDVGEAMAP PSHRKGDSNA NSDVCAAALR GLSRTILMCG PLIKEETHRR
410 420 430 440 450
LHDLVLPLVM GVQQGEVLGS SPYTSSRCRR ELYCLLLALL LAPSPRCPPP
460 470 480 490 500
LACALQAFSL GQREDSLEVS SFCSEALVTC AALTHPRVPP LQPMGPTCPT
510 520 530 540 550
PAPVPPPEAP SPFRAPPFHP PGPMPSVGSM PSAGPMPSAG PMPSAGPVPS
560 570 580 590 600
ARPGPPTTAN HLGLSVPGLV SVPPRLLPGP ENHRAGSNED PILAPSGTPP
610 620 630 640 650
PTIPPDETFG GRVPRPAFVH YDKEEASDVE ISLESDSDDS VVIVPEGLPP
660 670 680 690 700
LPPPPPSGAT PPPIAPTGPP TASPPVPAKE EPEELPAAPG PLPPPPPPPP
710 720 730 740 750
PVPGPVTLPP PQLVPEGTPG GGGPPALEED LTVININSSD EEEEEEEEEE
760 770 780 790 800
EEEEEEEEEE EDFEEEEEDE EEYFEEEEEE EEEFEEEFEE EEGELEEEEE
810 820 830 840 850
EEDEEEEEEL EEVEREGESP AAGPPPQELV EEEPSAPPTL LEEETEDGSD
860 870 880 890 900
KVQPPPETPA EEEMETETEA EALQEKEQDD TAAMLADFID CPPDDEKPPP

PTEPDS
Length:906
Mass (Da):96,907
Last modified:March 8, 2011 - v1
Checksum:i393DB76833B1B72C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091153 Genomic DNA. No translation available.
RefSeqiNP_001265170.1. NM_001278241.1.
UniGeneiHs.744899.

Genome annotation databases

EnsembliENST00000436683; ENSP00000416231; ENSG00000141456.
GeneIDi27043.
KEGGihsa:27043.
UCSCiuc010vsf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091153 Genomic DNA. No translation available.
RefSeqiNP_001265170.1. NM_001278241.1.
UniGeneiHs.744899.

3D structure databases

ProteinModelPortaliE7EV54.
SMRiE7EV54. Positions 69-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301396.

Proteomic databases

EPDiE7EV54.
PaxDbiE7EV54.
PRIDEiE7EV54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436683; ENSP00000416231; ENSG00000141456.
GeneIDi27043.
KEGGihsa:27043.
UCSCiuc010vsf.3. human.

Organism-specific databases

CTDi27043.
HGNCiHGNC:30134. PELP1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ4S. Eukaryota.
ENOG4110K7C. LUCA.
GeneTreeiENSGT00730000111225.
KOiK16913.

Miscellaneous databases

ChiTaRSiPELP1. human.
GenomeRNAii27043.

Gene expression databases

BgeeiE7EV54.
ExpressionAtlasiE7EV54. baseline and differential.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR012583. RIX1_N.
IPR012980. Uncharacterised_NUC202.
[Graphical view]
PfamiPF08166. NUC202. 2 hits.
PF08167. RIX1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE7EV54_HUMAN
AccessioniPrimary (citable) accession number: E7EV54
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 8, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.