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Protein
Submitted name:

Adhesion G protein-coupled receptor L3

Gene

ADGRL3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor L3Imported
Gene namesi
Name:ADGRL3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000150471.15
HGNCiHGNC:20974 ADGRL3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei947 – 970HelicalSequence analysisAdd BLAST24
Transmembranei982 – 1000HelicalSequence analysisAdd BLAST19
Transmembranei1006 – 1028HelicalSequence analysisAdd BLAST23
Transmembranei1049 – 1069HelicalSequence analysisAdd BLAST21
Transmembranei1089 – 1112HelicalSequence analysisAdd BLAST24
Transmembranei1143 – 1165HelicalSequence analysisAdd BLAST23
Transmembranei1171 – 1194HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150471

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500321734020 – 1308Sequence analysisAdd BLAST1289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi203 ↔ 385PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PeptideAtlasiE7EUP0
PRIDEiE7EUP0

Expressioni

Gene expression databases

BgeeiENSG00000150471
ExpressionAtlasiE7EUP0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EUP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 192SUEL-type lectinInterPro annotationAdd BLAST90
Domaini202 – 461Olfactomedin-likeInterPro annotationAdd BLAST260
Domaini566 – 622G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST57
Domaini883 – 934GPSInterPro annotationAdd BLAST52
Domaini945 – 1195G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
KOG4193 Eukaryota
KOG4729 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00900000140800

Family and domain databases

Gene3Di4.10.1240.101 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR015630 Latrophilin-3
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR12011:SF60 PTHR12011:SF60, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01444 LATROPHILIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

E7EUP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPSQLLIFM MLLAPIIHGG KHSERHPALA APLRHAERSP GGALPPRHLL
60 70 80 90 100
QQPAAERTAA HRGQGPRGAT RGVRGPGAQG AQIAAQAFSR APIPMAVVRR
110 120 130 140 150
ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD
160 170 180 190 200
AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV
210 220 230 240 250
FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL
260 270 280 290 300
TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD
310 320 330 340 350
LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN
360 370 380 390 400
GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN
410 420 430 440 450
EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY
460 470 480 490 500
HVVKYSLDFG PLDSRSGQAH HGQVSYISPP IHLDSELERP SVKDISTTGP
510 520 530 540 550
LGMGSTTTST TLRTTTLSPG RSTTPSVSGR RNRSTSTPSP AVEVLDDMTT
560 570 580 590 600
HLPSASSQIP ALEESCEAVE AREIMWFKTR QGQIAKQPCP AGTIGVSTYL
610 620 630 640 650
CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH
660 670 680 690 700
LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR
710 720 730 740 750
AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLHT VEESAFVLAD
760 770 780 790 800
NLLKTDIVRE NTDNIKLEVA RLSTEGNLED LKFPENMGHG STIQLSANTL
810 820 830 840 850
KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEALSTN HSVIVNSPVI
860 870 880 890 900
TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW
910 920 930 940 950
STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW
960 970 980 990 1000
VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN
1010 1020 1030 1040 1050
RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY
1060 1070 1080 1090 1100
FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII
1110 1120 1130 1140 1150
MLNVIFLGIA LYKMFHHTAI LKPESGCLDN INYEDNRPFI KSWVIGAIAL
1160 1170 1180 1190 1200
LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK
1210 1220 1230 1240 1250
EYGKCLRTHC CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV
1260 1270 1280 1290 1300
RKQSESSFIT GDINSSASLN REPYRETSMG VKLNIAYQIG ASEQCQGYKC

HGYSTTEW
Length:1,308
Mass (Da):146,210
Last modified:March 8, 2011 - v1
Checksum:i7539128B6D21FB1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020741 Genomic DNA No translation available.
AC092643 Genomic DNA No translation available.
AC092668 Genomic DNA No translation available.
AC096723 Genomic DNA No translation available.
AC104813 Genomic DNA No translation available.
AC108161 Genomic DNA No translation available.
KF457762 Genomic DNA No translation available.
KF457763 Genomic DNA No translation available.
RefSeqiXP_016863429.1, XM_017007940.1
UniGeneiHs.28391
Hs.570770

Genome annotation databases

EnsembliENST00000509896; ENSP00000423787; ENSG00000150471
GeneIDi23284
UCSCiuc062wxq.1 human

Similar proteinsi

Entry informationi

Entry nameiE7EUP0_HUMAN
AccessioniPrimary (citable) accession number: E7EUP0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported