E7EUK6 (E7EUK6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hepatic triacylglycerol lipase Ensembl ENSP00000395002

Gene names

Name:

LIPC Ensembl ENSP00000395002

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000395002

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family. RuleBase RU004262
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000395002

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS013818
Molecular function	Hydrolase RuleBase RU004263
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	triglyceride lipase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	107	1	Nucleophile By similarity PIRSR PIRSR000865-1
	Active site	133	1	Charge relay system By similarity PIRSR PIRSR000865-1
	Active site	218	1	Charge relay system By similarity PIRSR PIRSR000865-1

Sequences

	Sequence		Length	Mass (Da)
	E7EUK6 [UniParc]. Last modified March 8, 2011. Version 1. Checksum: A58A6858E271BEA4	FASTA	438	49,026
	10 20 30 40 50 60 MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT RFLLFGETNQ 70 80 90 100 110 120 GCQIRINHPD TLQECGFNSS LPLVMIIHGW SESVQLSRSH VHLIGYSLGA HVSGFAGSSI 130 140 150 160 170 180 GGTHKIGRIT GLDAAGPLFE GSAPSNRLSP DDANFVDAIH TFTREHMGLS VGIKQPIGHY 190 200 210 220 230 240 DFYPNGGSFQ PGCHFLELYR HIAQHGFNAI TQTIKCSHER SVHLFIDSLL HAGTQSMAYP 250 260 270 280 290 300 CGDMNSFSQG LCLSCKKGRC NTLGYHVRQE PRSKSKRLFL VTRAQSPFKV YHYQFKIQFI 310 320 330 340 350 360 NQTETPIQTT FTMSLLGTKE KMQKIPITLG KGIASNKTYS FLITLDVDIG ELIMIKFKWE 370 380 390 400 410 420 NSAVWANVWD TVQTIIPWST GPRHSGLVLK TIRVKAGETQ QRMTFCSENT DDLLLRPTQE 430 KIFVKCEIKS KTSKRKIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC018904 Genomic DNA. No translation available. AC084781 Genomic DNA. No translation available.
IPI	IPI00909632.
3D structure databases
ProteinModelPortal	E7EUK6.
SMR	E7EUK6. Positions 86-410.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000433326; ENSP00000395002; ENSG00000166035.
UCSC	uc010ugy.2. human.
Organism-specific databases
HGNC	HGNC:6619. LIPC.
GenAtlas	Search...
Gene expression databases
ArrayExpress	E7EUK6.
Bgee	E7EUK6.
Family and domain databases
Gene3D	2.60.60.20. 1 hit.
InterPro	IPR000734. Lipase. IPR002333. Lipase_hep. IPR008976. Lipase_LipOase. IPR013818. Lipase_N. IPR001024. LipOase_LH2. IPR016272. Lipoprotein_lipase_LIPH. [Graphical view]
PANTHER	PTHR11610. PTHR11610. 1 hit. PTHR11610:SF2. PTHR11610:SF2. 1 hit.
Pfam	PF00151. Lipase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view]
PIRSF	PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTS	PR00824. HEPLIPASE. PR00821. TAGLIPASE.
SMART	SM00308. LH2. 1 hit. [Graphical view]
SUPFAM	SSF49723. Lipase_LipOase. 1 hit.
PROSITE	PS50095. PLAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LIPC. human.
NextBio	35500503.

Entry information

Entry name

E7EUK6_HUMAN

Accession

Primary (citable) accession number: E7EUK6

Entry history

Integrated into UniProtKB/TrEMBL:	March 8, 2011
Last sequence update:	March 8, 2011
Last modified:	May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.