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E7EUK6

- E7EUK6_HUMAN

UniProt

E7EUK6 - E7EUK6_HUMAN

Protein
Submitted name:

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071NucleophileUniRule annotation
    Active sitei133 – 1331Charge relay systemUniRule annotation
    Active sitei218 – 2181Charge relay systemUniRule annotation

    GO - Molecular functioni

    1. triglyceride lipase activity Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hepatic triacylglycerol lipaseImported
    Gene namesi
    Name:LIPCImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:6619. LIPC.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiE7EUK6.
    BgeeiE7EUK6.

    Structurei

    3D structure databases

    ProteinModelPortaliE7EUK6.
    SMRiE7EUK6. Positions 86-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotation

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR002333. Lipase_hep.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PTHR11610:SF2. PTHR11610:SF2. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSiPR00824. HEPLIPASE.
    PR00821. TAGLIPASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEiPS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7EUK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT    50
    RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SESVQLSRSH 100
    VHLIGYSLGA HVSGFAGSSI GGTHKIGRIT GLDAAGPLFE GSAPSNRLSP 150
    DDANFVDAIH TFTREHMGLS VGIKQPIGHY DFYPNGGSFQ PGCHFLELYR 200
    HIAQHGFNAI TQTIKCSHER SVHLFIDSLL HAGTQSMAYP CGDMNSFSQG 250
    LCLSCKKGRC NTLGYHVRQE PRSKSKRLFL VTRAQSPFKV YHYQFKIQFI 300
    NQTETPIQTT FTMSLLGTKE KMQKIPITLG KGIASNKTYS FLITLDVDIG 350
    ELIMIKFKWE NSAVWANVWD TVQTIIPWST GPRHSGLVLK TIRVKAGETQ 400
    QRMTFCSENT DDLLLRPTQE KIFVKCEIKS KTSKRKIR 438
    Length:438
    Mass (Da):49,026
    Last modified:March 8, 2011 - v1
    Checksum:iA58A6858E271BEA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC018904 Genomic DNA. No translation available.
    AC084781 Genomic DNA. No translation available.
    KF456063 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000433326; ENSP00000395002; ENSG00000166035.
    UCSCiuc010ugy.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC018904 Genomic DNA. No translation available.
    AC084781 Genomic DNA. No translation available.
    KF456063 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E7EUK6.
    SMRi E7EUK6. Positions 86-410.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000433326 ; ENSP00000395002 ; ENSG00000166035 .
    UCSCi uc010ugy.2. human.

    Organism-specific databases

    HGNCi HGNC:6619. LIPC.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi LIPC. human.
    NextBioi 35500503.

    Gene expression databases

    ArrayExpressi E7EUK6.
    Bgeei E7EUK6.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR002333. Lipase_hep.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    PTHR11610:SF2. PTHR11610:SF2. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSi PR00824. HEPLIPASE.
    PR00821. TAGLIPASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEi PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7EUK6_HUMAN
    AccessioniPrimary (citable) accession number: E7EUK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3