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E7EUK6

- E7EUK6_HUMAN

UniProt

E7EUK6 - E7EUK6_HUMAN

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Protein
Submitted name: Hepatic triacylglycerol lipase
Gene
LIPC
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071Nucleophile By similarityUniRule annotation
Active sitei133 – 1331Charge relay system By similarityUniRule annotation
Active sitei218 – 2181Charge relay system By similarityUniRule annotation

GO - Molecular functioni

  1. triglyceride lipase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. lipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatic triacylglycerol lipaseImported
Gene namesi
Name:LIPCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:6619. LIPC.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiE7EUK6.
BgeeiE7EUK6.

Structurei

3D structure databases

ProteinModelPortaliE7EUK6.
SMRiE7EUK6. Positions 86-410.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotation

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EUK6-1 [UniParc]FASTAAdd to Basket

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MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT    50
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SESVQLSRSH 100
VHLIGYSLGA HVSGFAGSSI GGTHKIGRIT GLDAAGPLFE GSAPSNRLSP 150
DDANFVDAIH TFTREHMGLS VGIKQPIGHY DFYPNGGSFQ PGCHFLELYR 200
HIAQHGFNAI TQTIKCSHER SVHLFIDSLL HAGTQSMAYP CGDMNSFSQG 250
LCLSCKKGRC NTLGYHVRQE PRSKSKRLFL VTRAQSPFKV YHYQFKIQFI 300
NQTETPIQTT FTMSLLGTKE KMQKIPITLG KGIASNKTYS FLITLDVDIG 350
ELIMIKFKWE NSAVWANVWD TVQTIIPWST GPRHSGLVLK TIRVKAGETQ 400
QRMTFCSENT DDLLLRPTQE KIFVKCEIKS KTSKRKIR 438
Length:438
Mass (Da):49,026
Last modified:March 8, 2011 - v1
Checksum:iA58A6858E271BEA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000433326; ENSP00000395002; ENSG00000166035.
UCSCiuc010ugy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E7EUK6.
SMRi E7EUK6. Positions 86-410.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000433326 ; ENSP00000395002 ; ENSG00000166035 .
UCSCi uc010ugy.2. human.

Organism-specific databases

HGNCi HGNC:6619. LIPC.
GenAtlasi Search...

Miscellaneous databases

ChiTaRSi LIPC. human.
NextBioi 35500503.

Gene expression databases

ArrayExpressi E7EUK6.
Bgeei E7EUK6.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
Pfami PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEi PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7EUK6_HUMAN
AccessioniPrimary (citable) accession number: E7EUK6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi