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Protein
Submitted name:

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107NucleophileUniRule annotation1
Active sitei133Charge relay systemUniRule annotation1
Active sitei218Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatic triacylglycerol lipaseImported
Gene namesi
Name:LIPCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166035.10
HGNCiHGNC:6619 LIPC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166035

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500321754923 – 438Sequence analysisAdd BLAST416

Proteomic databases

PeptideAtlasiE7EUK6
PRIDEiE7EUK6

Expressioni

Gene expression databases

BgeeiENSG00000166035
ExpressionAtlasiE7EUK6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EUK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini291 – 425PLATInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119069

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 2 hits
PTHR11610:SF2 PTHR11610:SF2, 2 hits
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 2 hits
PRINTSiPR00824 HEPLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

E7EUK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT
60 70 80 90 100
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SESVQLSRSH
110 120 130 140 150
VHLIGYSLGA HVSGFAGSSI GGTHKIGRIT GLDAAGPLFE GSAPSNRLSP
160 170 180 190 200
DDANFVDAIH TFTREHMGLS VGIKQPIGHY DFYPNGGSFQ PGCHFLELYR
210 220 230 240 250
HIAQHGFNAI TQTIKCSHER SVHLFIDSLL HAGTQSMAYP CGDMNSFSQG
260 270 280 290 300
LCLSCKKGRC NTLGYHVRQE PRSKSKRLFL VTRAQSPFKV YHYQFKIQFI
310 320 330 340 350
NQTETPIQTT FTMSLLGTKE KMQKIPITLG KGIASNKTYS FLITLDVDIG
360 370 380 390 400
ELIMIKFKWE NSAVWANVWD TVQTIIPWST GPRHSGLVLK TIRVKAGETQ
410 420 430
QRMTFCSENT DDLLLRPTQE KIFVKCEIKS KTSKRKIR
Length:438
Mass (Da):49,026
Last modified:March 8, 2011 - v1
Checksum:iA58A6858E271BEA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018904 Genomic DNA No translation available.
AC084781 Genomic DNA No translation available.
KF456063 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000433326; ENSP00000395002; ENSG00000166035
UCSCiuc010ugy.3 human

Similar proteinsi

Entry informationi

Entry nameiE7EUK6_HUMAN
AccessioniPrimary (citable) accession number: E7EUK6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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