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E7EUJ1

- E7EUJ1_HUMAN

UniProt

E7EUJ1 - E7EUJ1_HUMAN

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Protein
Submitted name:

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681NucleophileUniRule annotation
Active sitei194 – 1941Charge relay systemUniRule annotation
Active sitei279 – 2791Charge relay systemUniRule annotation

GO - Molecular functioni

  1. triglyceride lipase activity Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatic triacylglycerol lipaseImported
Gene namesi
Name:LIPCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:6619. LIPC.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Expressioni

Gene expression databases

BgeeiE7EUJ1.
ExpressionAtlasiE7EUJ1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7EUJ1.
SMRiE7EUJ1. Positions 47-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119069.
OMAiCHFLELY.
PhylomeDBiE7EUJ1.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EUJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT
60 70 80 90 100
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI
110 120 130 140 150
WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW
160 170 180 190 200
LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF
210 220 230 240 250
EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF
260 270 280 290 300
QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY
310 320 330 340 350
PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK
360 370 380 390 400
VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY
410 420 430 440 450
SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL
460 470 480 490
KTIRVKAGET QQRSPNRINL GRLNCSLLFC TELFSHDSLA HWSSAASEL
Length:499
Mass (Da):55,617
Last modified:March 8, 2011 - v1
Checksum:iC5FED21BD5574072
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.
KF456063 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000414170; ENSP00000395569; ENSG00000166035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.
KF456063 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E7EUJ1.
SMRi E7EUJ1. Positions 47-425.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000414170 ; ENSP00000395569 ; ENSG00000166035 .

Organism-specific databases

HGNCi HGNC:6619. LIPC.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119069.
OMAi CHFLELY.
PhylomeDBi E7EUJ1.

Miscellaneous databases

ChiTaRSi LIPC. human.
NextBioi 35500499.

Gene expression databases

Bgeei E7EUJ1.
ExpressionAtlasi E7EUJ1. baseline and differential.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
Pfami PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEi PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7EUJ1_HUMAN
AccessioniPrimary (citable) accession number: E7EUJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3