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E7EUJ1

- E7EUJ1_HUMAN

UniProt

E7EUJ1 - E7EUJ1_HUMAN

Protein
Submitted name:

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei168 – 1681NucleophileUniRule annotation
    Active sitei194 – 1941Charge relay systemUniRule annotation
    Active sitei279 – 2791Charge relay systemUniRule annotation

    GO - Molecular functioni

    1. triglyceride lipase activity Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hepatic triacylglycerol lipaseImported
    Gene namesi
    Name:LIPCImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:6619. LIPC.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiE7EUJ1.
    BgeeiE7EUJ1.

    Structurei

    3D structure databases

    ProteinModelPortaliE7EUJ1.
    SMRiE7EUJ1. Positions 47-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotation

    Phylogenomic databases

    OMAiCHFLELY.
    PhylomeDBiE7EUJ1.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR002333. Lipase_hep.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PTHR11610:SF2. PTHR11610:SF2. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSiPR00824. HEPLIPASE.
    PR00821. TAGLIPASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEiPS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7EUJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT    50
    RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI 100
    WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW 150
    LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF 200
    EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF 250
    QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY 300
    PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK 350
    VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY 400
    SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL 450
    KTIRVKAGET QQRSPNRINL GRLNCSLLFC TELFSHDSLA HWSSAASEL 499
    Length:499
    Mass (Da):55,617
    Last modified:March 8, 2011 - v1
    Checksum:iC5FED21BD5574072
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC018904 Genomic DNA. No translation available.
    AC084781 Genomic DNA. No translation available.
    KF456063 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000414170; ENSP00000395569; ENSG00000166035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC018904 Genomic DNA. No translation available.
    AC084781 Genomic DNA. No translation available.
    KF456063 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E7EUJ1.
    SMRi E7EUJ1. Positions 47-425.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000414170 ; ENSP00000395569 ; ENSG00000166035 .

    Organism-specific databases

    HGNCi HGNC:6619. LIPC.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi CHFLELY.
    PhylomeDBi E7EUJ1.

    Miscellaneous databases

    ChiTaRSi LIPC. human.
    NextBioi 35500499.

    Gene expression databases

    ArrayExpressi E7EUJ1.
    Bgeei E7EUJ1.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR002333. Lipase_hep.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    PTHR11610:SF2. PTHR11610:SF2. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSi PR00824. HEPLIPASE.
    PR00821. TAGLIPASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEi PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7EUJ1_HUMAN
    AccessioniPrimary (citable) accession number: E7EUJ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3