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Protein
Submitted name:

Rho guanine nucleotide exchange factor 3

Gene

ARHGEF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 3Imported
Gene namesi
Name:ARHGEF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:683. ARHGEF3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163947.

PTM / Processingi

Proteomic databases

EPDiE7EU49.
MaxQBiE7EU49.
PaxDbiE7EU49.
PRIDEiE7EU49.

Expressioni

Gene expression databases

BgeeiENSG00000163947.
ExpressionAtlasiE7EU49. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341071.

Structurei

3D structure databases

ProteinModelPortaliE7EU49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 275DH (DBL-homology)InterPro annotationAdd BLAST183
Domaini262 – 420PHInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiKOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000119193.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EU49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEEPSNKRV KPLSRVTSLA NLIPPVKATP LKRFSQTLQR SISFRSESRP
60 70 80 90 100
DILAPRPWSR NAAPSSTKRR DSKLWSETFD VCVNQMLTSK EIKRQEAIFE
110 120 130 140 150
LSQGEEDLIE DLKLAKKAYH DPMLKLSIMT EQELNQIFGT LDSLIPLHEE
160 170 180 190 200
LLSQLRDVRK PDGSTEHVGP ILVGWLPCLS SYDSYCSNQV AAKALLDHKK
210 220 230 240 250
QDHRVQDFLQ RCLESPFSRK LDLWNFLDIP RSRLVKYPLL LREILRHTPN
260 270 280 290 300
DNPDQQHLEE AINIIQGIVA EINTKTGESE CRYYKERLLY LEEGQKDSLI
310 320 330 340 350
DSSRVLCCHG ELKNNRGVKL HVFLFQEVLV ITRAVTHNEQ LCYQLYRQPI
360 370 380 390 400
PVKDLLLEDL QDGEVRLGGS LRGAFSNNER IKNFFRVSFK NGSQSQTHSL
410 420 430 440 450
QANDTFNKQQ WLNCIRQAKE TVLCAAGQAG VLDSEGSFLN PTTGSRELQG
460 470 480 490
ETKLEQMDQS DSESDCSMDT SEVSLDCERM EQTDSSCGNS RHGESNV
Length:497
Mass (Da):56,691
Last modified:March 8, 2011 - v1
Checksum:iF8AE7F41098B267C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097358 Genomic DNA. No translation available.
AC099327 Genomic DNA. No translation available.
AC099559 Genomic DNA. No translation available.
AC099781 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000497267; ENSP00000418826; ENSG00000163947.
UCSCiuc011bev.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097358 Genomic DNA. No translation available.
AC099327 Genomic DNA. No translation available.
AC099559 Genomic DNA. No translation available.
AC099781 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE7EU49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341071.

Proteomic databases

EPDiE7EU49.
MaxQBiE7EU49.
PaxDbiE7EU49.
PRIDEiE7EU49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000497267; ENSP00000418826; ENSG00000163947.
UCSCiuc011bev.2. human.

Organism-specific databases

HGNCiHGNC:683. ARHGEF3.
OpenTargetsiENSG00000163947.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000119193.

Miscellaneous databases

ChiTaRSiARHGEF3. human.

Gene expression databases

BgeeiENSG00000163947.
ExpressionAtlasiE7EU49. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7EU49_HUMAN
AccessioniPrimary (citable) accession number: E7EU49
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.