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Protein
Submitted name:

Rho guanine nucleotide exchange factor 3

Gene

ARHGEF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 3Imported
Gene namesi
Name:ARHGEF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000163947.11
HGNCiHGNC:683 ARHGEF3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163947

PTM / Processingi

Proteomic databases

EPDiE7EU49
MaxQBiE7EU49
PRIDEiE7EU49

Expressioni

Gene expression databases

BgeeiENSG00000163947
ExpressionAtlasiE7EU49 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE7EU49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 275DHInterPro annotationAdd BLAST183
Domaini262 – 420PHInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiKOG4305 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000119193

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

E7EU49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEEPSNKRV KPLSRVTSLA NLIPPVKATP LKRFSQTLQR SISFRSESRP
60 70 80 90 100
DILAPRPWSR NAAPSSTKRR DSKLWSETFD VCVNQMLTSK EIKRQEAIFE
110 120 130 140 150
LSQGEEDLIE DLKLAKKAYH DPMLKLSIMT EQELNQIFGT LDSLIPLHEE
160 170 180 190 200
LLSQLRDVRK PDGSTEHVGP ILVGWLPCLS SYDSYCSNQV AAKALLDHKK
210 220 230 240 250
QDHRVQDFLQ RCLESPFSRK LDLWNFLDIP RSRLVKYPLL LREILRHTPN
260 270 280 290 300
DNPDQQHLEE AINIIQGIVA EINTKTGESE CRYYKERLLY LEEGQKDSLI
310 320 330 340 350
DSSRVLCCHG ELKNNRGVKL HVFLFQEVLV ITRAVTHNEQ LCYQLYRQPI
360 370 380 390 400
PVKDLLLEDL QDGEVRLGGS LRGAFSNNER IKNFFRVSFK NGSQSQTHSL
410 420 430 440 450
QANDTFNKQQ WLNCIRQAKE TVLCAAGQAG VLDSEGSFLN PTTGSRELQG
460 470 480 490
ETKLEQMDQS DSESDCSMDT SEVSLDCERM EQTDSSCGNS RHGESNV
Length:497
Mass (Da):56,691
Last modified:March 8, 2011 - v1
Checksum:iF8AE7F41098B267C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097358 Genomic DNA No translation available.
AC099327 Genomic DNA No translation available.
AC099559 Genomic DNA No translation available.
AC099781 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000497267; ENSP00000418826; ENSG00000163947
UCSCiuc011bev.2 human

Similar proteinsi

Entry informationi

Entry nameiE7EU49_HUMAN
AccessioniPrimary (citable) accession number: E7EU49
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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