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Protein
Submitted name:

Treacle protein

Gene

TCOF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Treacle proteinImported
Gene namesi
Name:TCOF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000070814.17.
HGNCiHGNC:11654. TCOF1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000070814.

PTM / Processingi

Proteomic databases

EPDiE7ETY2.
MaxQBiE7ETY2.
PaxDbiE7ETY2.
PeptideAtlasiE7ETY2.
PRIDEiE7ETY2.

Expressioni

Gene expression databases

BgeeiENSG00000070814.
ExpressionAtlasiE7ETY2. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE7ETY2. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliE7ETY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 38LisHInterPro annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1440 – 1467Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IF55. Eukaryota.
ENOG411183W. LUCA.
GeneTreeiENSGT00730000111382.

Family and domain databases

InterProiView protein in InterPro
IPR006594. LisH.
IPR003993. TCS_treacle.
IPR017859. Treacle-like_TCS.
PfamiView protein in Pfam
PF03546. Treacle. 4 hits.
PRINTSiPR01503. TREACLE.
SMARTiView protein in SMART
SM00667. LisH. 1 hit.
PROSITEiView protein in PROSITE
PS50896. LISH. 1 hit.

Sequencei

Sequence statusi: Complete.

E7ETY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY
60 70 80 90 100
THWQQTSELG RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK
110 120 130 140 150
ATPRLASTNS SVLGADLPSS MKEKAKAETE KAGKTGNSMP HPATGKTVAN
160 170 180 190 200
LLSGKSPRKS AEPSANTTLV SETEEEGSVP AFGAAAKPGM VSAGQADSSS
210 220 230 240 250
EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP APGKVGDVTP
260 270 280 290 300
QVKGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTRSQ VKASEKILQV
310 320 330 340 350
RAASAPAKGT PGKGATPAPP GKAGAVASQT KAGKPEEDSE SSSEESSDSE
360 370 380 390 400
EETPAAKALL QAKASGKTSQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK
410 420 430 440 450
AQAGKREEDS QSSSEESDSE EEAPAQAKPS GKAPQVRAAS APAKESPRKG
460 470 480 490 500
AAPAPPRKTG PAAAQVQVGK QEEDSRSSSE ESDSDREALA AMNAAQVKPL
510 520 530 540 550
GKSPQVKPAS TMGMGPLGKG AGPVPPGKVG PATPSAQVGK WEEDSESSSE
560 570 580 590 600
ESSDSSDGEV PTAVAPAQEK SLGNILQAKP TSSPAKGPPQ KAGPVAVQVK
610 620 630 640 650
AEKPMDNSES SEESSDSADS EEAPAAMTAA QAKPALKIPQ TKACPKKTNT
660 670 680 690 700
TASAKVAPVR VGTQAPRKAG TATSPAGSSP AVAGGTQRPA EDSSSSEESD
710 720 730 740 750
SEEEKTGLAV TVGQAKSVGK GLQVKAASVP VKGSLGQGTA PVLPGKTGPT
760 770 780 790 800
VTQVKAEKQE DSESSEEESD SEEAAASPAQ VKTSVKKTQA KANPAAARAP
810 820 830 840 850
SAKGTISAPG KVVTAAAQAK QRSPSKVKPP VRNPQNSTVL ARGPASVPSV
860 870 880 890 900
GKAVATAAQA QTGPEEDSGS SEEESDSEEE AETLAQVKPS GKTHQIRAAL
910 920 930 940 950
APAKESPRKG AAPTPPGKTG PSAAQAGKQD DSGSSSEESD SDGEAPAAVT
960 970 980 990 1000
SAQKDSNSKP ARSKTLAPAP PERNTEGSSE SSEEELPLTQ VIKPPLIFVD
1010 1020 1030 1040 1050
PNRSPAGPAA TPAQAQAAST PRKARASEST ARSSSSESED EDVIPATQCL
1060 1070 1080 1090 1100
TPGIRTNVVT MPTAHPRIAP KASMAGASSS KESSRISDGK KQEGPATQVD
1110 1120 1130 1140 1150
SAVGTLPATS PQSTSVQAKG TNKLRKPKLP EVQQATKAPE SSDDSEDSSD
1160 1170 1180 1190 1200
SSSGSEEDGE GPQGAKSAHT LVGPTPSRTE TLVEETAAES SEDDVVAPSQ
1210 1220 1230 1240 1250
SLLSGYMTPG LTPANSQASK ATPKLDSSPS VSSTLAAKDD PDGKQEAKPQ
1260 1270 1280 1290 1300
QAAGMLSPKT GGKEAASGTT PQKSRKPKKG AGNPQASTLA LQSNITQCLL
1310 1320 1330 1340 1350
GQPWPLNEAQ VQASVVKVLT ELLEQERKKV VDTTKESSRK GWESRKRKLS
1360 1370 1380 1390 1400
GDQPAARTPR SKKKKKLGAG EGGEASVSPE KTSTTSKGKA KRDKASGDVK
1410 1420 1430 1440 1450
EKKGKGSLGS QGAKDEPEEE LQKGMGTVEG GDQSNPKSKK EKKKSDKRKK
1460 1470 1480
DKEKKEKKKK AKKASTKDSE SPSQKKKKKK KKTAEQTV
Length:1,488
Mass (Da):152,304
Last modified:March 8, 2011 - v1
Checksum:i4FC162CCA7AE6659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011372 Genomic DNA. No translation available.
RefSeqiXP_005268563.1. XM_005268506.3.
UniGeneiHs.519672.
Hs.605019.

Genome annotation databases

EnsembliENST00000513346; ENSP00000427484; ENSG00000070814.
GeneIDi6949.
UCSCiuc063iqw.1. human.

Similar proteinsi

Entry informationi

Entry nameiE7ETY2_HUMAN
AccessioniPrimary (citable) accession number: E7ETY2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 27, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported