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Protein

RuvB-like helicase

Gene

RUVBL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotationSAAS annotation, Hydrolase
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicaseUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:RUVBL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175792.11
HGNCiHGNC:10474 RUVBL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175792

PTM / Processingi

Proteomic databases

MaxQBiE7ETR0
PeptideAtlasiE7ETR0
PRIDEiE7ETR0

Expressioni

Gene expression databases

BgeeiENSG00000175792
ExpressionAtlasiE7ETR0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7ETR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 305AAAInterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1942 Eukaryota
COG1224 LUCA
GeneTreeiENSGT00890000139499

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR027238 RuvB-like
IPR037938 RUVBL1
IPR010339 TIP49_C
PANTHERiPTHR11093 PTHR11093, 1 hit
PTHR11093:SF6 PTHR11093:SF6, 1 hit
PfamiView protein in Pfam
PF06068 TIP49, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

E7ETR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE
60 70 80 90 100
VLMENFRRAI GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG
110 120 130 140 150
LKTAKGTKQL KLDPSIFESL QKERVEAGDV IYIEANSGAV KRQGRCDTYA
160 170 180 190 200
TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL HDLDVANARP QGGQDILSMM
210 220 230 240 250
GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF VDEVHMLDIE
260 270 280 290 300
CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI
310
IRTMLYTPQE MKQVP
Length:315
Mass (Da):34,782
Last modified:March 8, 2011 - v1
Checksum:i5D7D260245EE45FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011311 Genomic DNA No translation available.
AC069419 Genomic DNA No translation available.
AL449214 Genomic DNA No translation available.
RefSeqiNP_001306015.1, NM_001319086.1
UniGeneiHs.272822

Genome annotation databases

EnsembliENST00000464873; ENSP00000420738; ENSG00000175792
GeneIDi8607
UCSCiuc003ekf.3 human

Similar proteinsi

Entry informationi

Entry nameiE7ETR0_HUMAN
AccessioniPrimary (citable) accession number: E7ETR0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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