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Protein

Eyes absent homolog

Gene

EYA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homologUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:EYA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000064655.18.
HGNCiHGNC:3520. EYA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064655.

Expressioni

Gene expression databases

BgeeiENSG00000064655.
ExpressionAtlasiE7ETN2. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. EYA family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000008860.

Family and domain databases

CDDicd02601. HAD_Eya. 1 hit.
InterProiView protein in InterPro
IPR028473. EYA2.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
IPR036412. HAD-like_sf.
PANTHERiPTHR10190. PTHR10190. 2 hits.
PTHR10190:SF7. PTHR10190:SF7. 2 hits.
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

Sequencei

Sequence statusi: Complete.

E7ETN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF
60 70 80 90 100
SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS
110 120 130 140 150
IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL
160 170 180 190 200
GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS
210 220 230 240 250
TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR
260 270 280 290 300
GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDCDQ
310 320 330 340 350
IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL
360 370 380 390 400
AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK
410 420 430 440 450
ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK
460 470 480 490 500
ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR

HALELEYL
Length:508
Mass (Da):55,745
Last modified:March 8, 2011 - v1
Checksum:iC2DAC8AE5D83042D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022342 Genomic DNA. No translation available.
AL121776 Genomic DNA. No translation available.
AL354766 Genomic DNA. No translation available.
AL359434 Genomic DNA. No translation available.
KF456925 Genomic DNA. No translation available.
KF456926 Genomic DNA. No translation available.
RefSeqiXP_016883210.1. XM_017027721.1.
UniGeneiHs.472877.
Hs.722040.
Hs.722415.
Hs.722416.

Genome annotation databases

EnsembliENST00000317304; ENSP00000321590; ENSG00000064655.
ENST00000611592; ENSP00000483392; ENSG00000064655.
GeneIDi2139.
UCSCiuc002xsq.4. human.

Similar proteinsi

Entry informationi

Entry nameiE7ETN2_HUMAN
AccessioniPrimary (citable) accession number: E7ETN2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 25, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported