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Protein

Zinc finger protein 587B

Gene

ZNF587B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri120 – 14223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 38330C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 587B
Gene namesi
Name:ZNF587B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:37142. ZNF587B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZNF587B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Zinc finger protein 587BPRO_0000416243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki200 – 200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki253 – 253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki366 – 366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiE7ETH6.
PaxDbiE7ETH6.
PRIDEiE7ETH6.

PTM databases

iPTMnetiE7ETH6.

Expressioni

Gene expression databases

BgeeiE7ETH6.
ExpressionAtlasiE7ETH6. baseline and differential.
GenevisibleiE7ETH6. HS.

Organism-specific databases

HPAiHPA043800.
HPA053762.

Interactioni

Protein-protein interaction databases

BioGridi945166. 1 interaction.
STRINGi9606.ENSP00000392410.

Structurei

3D structure databases

ProteinModelPortaliE7ETH6.
SMRiE7ETH6. Positions 106-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9177KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri120 – 14223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 38330C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
InParanoidiE7ETH6.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7ETH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVATLRLS AQGTVTFEDV AVKFTQEEWN LLSEAQRCLY RDVTLENLAL
60 70 80 90 100
MSSLGCWCGV EDEAAPSKQS IYIQRETQVR TPVTGVSPKK AHPCEMCGPI
110 120 130 140 150
LGDILHVADH QGTHHKQKLH RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG
160 170 180 190 200
SVEEALFVKR CKLHVSGESS VFSESGKDFL PRSGLLQQEA SHTGEKSNSK
210 220 230 240 250
TECVSPFQCG GAHYSHGDSM KHFSTKHILS QHQRLLPREE CYVCCECGKS
260 270 280 290 300
FSKYVSFSNH QRVHSGKRPY ECGECEKSFS QKSSLIQHQQ FHTGGKPYGC
310 320 330 340 350
EECGKYFSLE GYLRRHQKVH AGKGPYECGE CGKSFSSNVN LKSHQRIHTG
360 370 380 390 400
ERPYKCGECE KSFSRKPSLS YHQRFGRPRW VDHKDRKEFK TSLGNIVKSC

LF
Length:402
Mass (Da):45,541
Last modified:March 8, 2011 - v1
Checksum:i57CEA54233B91BAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831V → M in BAG61153 (PubMed:14702039).Curated
Sequence conflicti390 – 3901K → G in BAG61153 (PubMed:14702039).Curated
Sequence conflicti396 – 3961I → M in BAG61153 (PubMed:14702039).Curated
Sequence conflicti398 – 3981K → R in BAG61153 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299091 mRNA. Translation: BAG61153.1.
AC010522 Genomic DNA. No translation available.
CCDSiCCDS56109.1.
RefSeqiNP_001191747.1. NM_001204818.1.
UniGeneiHs.658251.
Hs.744891.

Genome annotation databases

EnsembliENST00000442832; ENSP00000392410; ENSG00000269343.
GeneIDi100293516.
KEGGihsa:100293516.
UCSCiuc021vcp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299091 mRNA. Translation: BAG61153.1.
AC010522 Genomic DNA. No translation available.
CCDSiCCDS56109.1.
RefSeqiNP_001191747.1. NM_001204818.1.
UniGeneiHs.658251.
Hs.744891.

3D structure databases

ProteinModelPortaliE7ETH6.
SMRiE7ETH6. Positions 106-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi945166. 1 interaction.
STRINGi9606.ENSP00000392410.

PTM databases

iPTMnetiE7ETH6.

Polymorphism and mutation databases

BioMutaiZNF587B.

Proteomic databases

MaxQBiE7ETH6.
PaxDbiE7ETH6.
PRIDEiE7ETH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442832; ENSP00000392410; ENSG00000269343.
GeneIDi100293516.
KEGGihsa:100293516.
UCSCiuc021vcp.2. human.

Organism-specific databases

CTDi100293516.
GeneCardsiZNF587B.
HGNCiHGNC:37142. ZNF587B.
HPAiHPA043800.
HPA053762.
neXtProtiNX_E7ETH6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
InParanoidiE7ETH6.

Miscellaneous databases

GenomeRNAii100293516.
PROiE7ETH6.

Gene expression databases

BgeeiE7ETH6.
ExpressionAtlasiE7ETH6. baseline and differential.
GenevisibleiE7ETH6. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-366, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZ587B_HUMAN
AccessioniPrimary (citable) accession number: E7ETH6
Secondary accession number(s): B4DR41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 8, 2011
Last modified: June 8, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.