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Protein

Zinc finger protein 587B

Gene

ZNF587B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 587B
Gene namesi
Name:ZNF587B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000269343.6
HGNCiHGNC:37142 ZNF587B
neXtProtiNX_E7ETH6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100293516
OpenTargetsiENSG00000269343

Polymorphism and mutation databases

BioMutaiZNF587B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004162431 – 402Zinc finger protein 587BAdd BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiE7ETH6
PaxDbiE7ETH6
PRIDEiE7ETH6

PTM databases

iPTMnetiE7ETH6
PhosphoSitePlusiE7ETH6

Expressioni

Gene expression databases

BgeeiENSG00000269343
ExpressionAtlasiE7ETH6 baseline and differential
GenevisibleiE7ETH6 HS

Organism-specific databases

HPAiHPA043800
HPA053762
HPA072145

Interactioni

Protein-protein interaction databases

BioGridi945166, 2 interactors
STRINGi9606.ENSP00000392410

Structurei

3D structure databases

ProteinModelPortaliE7ETH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 91KRABPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
InParanoidiE7ETH6

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

E7ETH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVATLRLS AQGTVTFEDV AVKFTQEEWN LLSEAQRCLY RDVTLENLAL
60 70 80 90 100
MSSLGCWCGV EDEAAPSKQS IYIQRETQVR TPVTGVSPKK AHPCEMCGPI
110 120 130 140 150
LGDILHVADH QGTHHKQKLH RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG
160 170 180 190 200
SVEEALFVKR CKLHVSGESS VFSESGKDFL PRSGLLQQEA SHTGEKSNSK
210 220 230 240 250
TECVSPFQCG GAHYSHGDSM KHFSTKHILS QHQRLLPREE CYVCCECGKS
260 270 280 290 300
FSKYVSFSNH QRVHSGKRPY ECGECEKSFS QKSSLIQHQQ FHTGGKPYGC
310 320 330 340 350
EECGKYFSLE GYLRRHQKVH AGKGPYECGE CGKSFSSNVN LKSHQRIHTG
360 370 380 390 400
ERPYKCGECE KSFSRKPSLS YHQRFGRPRW VDHKDRKEFK TSLGNIVKSC

LF
Length:402
Mass (Da):45,541
Last modified:March 8, 2011 - v1
Checksum:i57CEA54233B91BAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83V → M in BAG61153 (PubMed:14702039).Curated1
Sequence conflicti390K → G in BAG61153 (PubMed:14702039).Curated1
Sequence conflicti396I → M in BAG61153 (PubMed:14702039).Curated1
Sequence conflicti398K → R in BAG61153 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299091 mRNA Translation: BAG61153.1
AC010522 Genomic DNA No translation available.
CCDSiCCDS56109.1
RefSeqiNP_001191747.1, NM_001204818.1
UniGeneiHs.658251
Hs.744891

Genome annotation databases

EnsembliENST00000442832; ENSP00000392410; ENSG00000269343
GeneIDi100293516
KEGGihsa:100293516
UCSCiuc021vcp.2 human

Similar proteinsi

Entry informationi

Entry nameiZ587B_HUMAN
AccessioniPrimary (citable) accession number: E7ETH6
Secondary accession number(s): B4DR41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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