ID E7ETE3_HUMAN Unreviewed; 1571 AA. AC E7ETE3; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 27-MAR-2024, entry version 91. DE SubName: Full=Adhesion G protein-coupled receptor L3 {ECO:0000313|Ensembl:ENSP00000425884.1}; GN Name=ADGRL3 {ECO:0000313|Ensembl:ENSP00000425884.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425884.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000425884.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000425884.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC020741; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092643; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092668; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC096723; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC104813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC108161; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457763; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; E7ETE3; -. DR MassIVE; E7ETE3; -. DR PeptideAtlas; E7ETE3; -. DR ProteomicsDB; 18189; -. DR Antibodypedia; 2755; 192 antibodies from 31 providers. DR Ensembl; ENST00000506746.5; ENSP00000425884.1; ENSG00000150471.17. DR UCSC; uc062wxy.1; human. DR HGNC; HGNC:20974; ADGRL3. DR VEuPathDB; HostDB:ENSG00000150471; -. DR GeneTree; ENSGT00940000155527; -. DR ChiTaRS; ADGRL3; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000150471; Expressed in adrenal tissue and 180 other cell types or tissues. DR ExpressionAtlas; E7ETE3; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR CDD; cd16005; 7tmB2_Latrophilin-3; 1. DR CDD; cd22846; Gal_Rha_Lectin_LPHN3; 1. DR Gene3D; 1.25.40.610; -; 1. DR Gene3D; 2.60.120.740; -; 1. DR Gene3D; 2.60.220.50; -; 1. DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR032471; GAIN_dom_N. DR InterPro; IPR046338; GAIN_dom_sf. DR InterPro; IPR017981; GPCR_2-like_7TM. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR003924; GPCR_2_latrophilin. DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR InterPro; IPR000203; GPS. DR InterPro; IPR000922; Lectin_gal-bd_dom. DR InterPro; IPR043159; Lectin_gal-bd_sf. DR InterPro; IPR003112; Olfac-like_dom. DR PANTHER; PTHR12011:SF60; ADHESION G PROTEIN-COUPLED RECEPTOR L3; 1. DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF16489; GAIN; 1. DR Pfam; PF02140; Gal_Lectin; 1. DR Pfam; PF01825; GPS; 1. DR Pfam; PF02793; HRM; 1. DR Pfam; PF02354; Latrophilin; 1. DR Pfam; PF02191; OLF; 1. DR PRINTS; PR00249; GPCRSECRETIN. DR PRINTS; PR01444; LATROPHILIN. DR SMART; SM00303; GPS; 1. DR SMART; SM00008; HormR; 1. DR SMART; SM00284; OLF; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR PROSITE; PS50221; GPS; 1. DR PROSITE; PS51132; OLF; 1. DR PROSITE; PS50228; SUEL_LECTIN; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Proteomics identification {ECO:0007829|EPD:E7ETE3, KW ECO:0007829|MaxQB:E7ETE3}; Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|ARBA:ARBA00023224}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..1571 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003217333" FT TRANSMEM 947..970 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 982..1000 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1006..1028 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1049..1069 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1089..1112 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1133..1156 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1162..1185 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 103..192 FT /note="SUEL-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50228" FT DOMAIN 202..461 FT /note="Olfactomedin-like" FT /evidence="ECO:0000259|PROSITE:PS51132" FT DOMAIN 566..622 FT /note="G-protein coupled receptors family 2 profile 1" FT /evidence="ECO:0000259|PROSITE:PS50227" FT DOMAIN 945..1186 FT /note="G-protein coupled receptors family 2 profile 2" FT /evidence="ECO:0000259|PROSITE:PS50261" FT REGION 53..77 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 494..541 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1205..1229 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1547..1571 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 498..541 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 203..385 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446" SQ SEQUENCE 1571 AA; 174909 MW; 0E28BBFDF577FFDF CRC64; MWPSQLLIFM MLLAPIIHGG KHSERHPALA APLRHAERSP GGALPPRHLL QQPAAERTAA HRGQGPRGAT RGVRGPGAQG AQIAAQAFSR APIPMAVVRR ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY HVVKYSLDFG PLDSRSGQAH HGQVSYISPP IHLDSELERP SVKDISTTGP LGMGSTTTST TLRTTTLSPG RSTTPSVSGR RNRSTSTPSP AVEVLDDMTT HLPSASSQIP ALEESCEAVE AREIMWFKTR QGQIAKQPCP AGTIGVSTYL CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLHT VEESAFVLAD NLLKTDIVRE NTDNIKLEVA RLSTEGNLED LKFPENMGHG STIQLSANTL KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEALSTN HSVIVNSPVI TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII MLNVIFLGIA LYKMFHHTAI LKPESGCLDN IKSWVIGAIA LLCLLGLTWA FGLMYINEST VIMAYLFTIF NSLQGMFIFI FHCVLQKKVR KEYGKCLRTH CCSGKSTESS IGSGKTSGSR TPGRYSTGSQ SRIRRMWNDT VRKQSESSFI TGDINSSASL NRGAMANHLI SNALLRPHGT NNPYNTLLGE PAVCNNPSVS MYNAQEGLLN NARDTSVMDT LPLNGNHGNS YSIASGEYLS NCVQIIDRGY NHNETALEKK ILKELTSNYI PSYLNNHERS SEQNRNLMNK LVNNLGSGRE DDAIVLDDAT SFNHEESLGL ELIHEESDAP LLPPRVYSTE NHQPHHYTRR RIPQDHSESF FPLLTNEHTE DLQSPHRDSL YTSMPTLAGV AATESVTTST QTEPPPAKCG DAEDVYYKSM PNLGSRNHVH QLHTYYQLGR GSSDGFIVPP NKDGTPPEGS SKGPAHLVTS L //