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E7ET55

- E7ET55_HUMAN

UniProt

E7ET55 - E7ET55_HUMAN

Protein
Submitted name:

WND/140 kDa

Gene

ATP7B

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. copper ion binding Source: InterPro

    GO - Biological processi

    1. copper ion transport Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    WND/140 kDaImported
    Gene namesi
    Name:ATP7BImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:870. ATP7B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiE7ET55.
    BgeeiE7ET55.

    Structurei

    3D structure databases

    ProteinModelPortaliE7ET55.
    SMRiE7ET55. Positions 58-1301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    KOiK17686.

    Family and domain databases

    Gene3Di2.70.150.10. 1 hit.
    3.40.1110.10. 2 hits.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR027256. Cation_transp_P-typ_ATPase_IB.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    IPR006122. HMA_Cu_ion-bd.
    [Graphical view]
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    PF00403. HMA. 6 hits.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF55008. SSF55008. 6 hits.
    SSF56784. SSF56784. 2 hits.
    TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    TIGR00003. TIGR00003. 6 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    PS01047. HMA_1. 6 hits.
    PS50846. HMA_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7ET55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEQERQITA REGASRKILS KLSLPTRAWE PAMKKSFAFD NVGYEGGLDG     50
    LGPSSQVATS TVRILGMTCQ SCVKSIEDRI SNLKGIISMK VSLEQGSATV 100
    KYVPSVVCLQ QVCHQIGDMG FEASIAEGKA ASWPSRSLPA QEAVVKLRVE 150
    GMTCQSCVSS IEGKVRKLQG VVRVKVSLSN QEAVITYQPY LIQPEDLRDH 200
    VNDMGFEAAI KSKVAPLSLG PIDIERLQST NPKRPLSSAN QNFNNSETLG 250
    HQGSHVVTLQ LRIDGMHCKS CVLNIEENIG QLLGVQSIQV SLENKTAQVK 300
    YDPSCTSPVA LQRAIEALPP GNFKVSLPDG AEGSGTDHRS SSSHSPGSPP 350
    RNQVQGTCST TLIAIAGMTC ASCVHSIEGM ISQLEGVQQI SVSLAEGTAT 400
    VLYNPSVISP EELRAAIEDM GFEASVVSES CSTNPLGNHS AGNSMVQTTD 450
    GTPTSVQEVA PHTGRLPANH APDILAKSPQ STRAVAPQKC FLQIKGMTCA 500
    SCVSNIERNL QKEAGVLSVL VALMAGKAEI KYDPEVIQPL EIAQFIQDLG 550
    FEAAVMEDYA GSDGNIELTI TGMTCASCVH NIESKLTRTN GITYASVALA 600
    TSKALVKFDP EIIGPRDIIK IIEEIGFHAS LAQRNPNAHH LDHKMEIKQW 650
    KKSFLCSLVF GIPVMALMIY MLIPSNEPHQ SMVLDHNIIP GLSILNLIFF 700
    ILCTFVQSKT SEALAKLMSL QATEATVVTL GEDNLIIREE QVPMELVQRG 750
    DIVKVVPGGK FPVDGKVLEG NTMADESLIT GEAMPVTKKP GSTVIAGSIN 800
    AHGSVLIKAT HVGNDTTLAQ IVKLVEEAQM SKAPIQQLAD RFSGYFVPFI 850
    IIMSTLTLVV WIVIGFIDFG VVQRYFPNPN KHISQTEVII RFAFQTSITV 900
    LCIACPCSLG LATPTAVMVG TGVAAQNGIL IKGGKPLEMA HKIKTVMFDK 950
    TGTITHGVPR VMRVLLLGDV ATLPLRKVLA VVGTAEASSE HPLGVAVTKY 1000
    CKEELGTETL GYCTDFQAVP GCGIGCKVSN VEGILAHSER PLSAPASHLN 1050
    EAGSLPAEKD AVPQTFSVLI GNREWLRRNG LTISSDVSDA MTDHEMKGQT 1100
    AILVAIDGVL CGMIAIADAV KQEAALAVHT LQSMGVDVVL ITGDNRKTAR 1150
    AIATQVGINK VFAEVLPSHK VAKVQELQNK GKKVAMVGDG VNDSPALAQA 1200
    DMGVAIGTGT DVAIEAADVV LIRNDLLDVV ASIHLSKRTV RRIRINLVLA 1250
    LIYNLVGIPI AAGVFMPIGI VLQPWMGSAA MAASSVSVVL SSLQLKCYKK 1300
    PDLERYEAQA HGHMKPLTAS QVSVHIGMDD RWRDSPRATP WDQVSYVSQV 1350
    SLSSLTSDKP SRHSAAADDD GDKWSLLLNG RDEEQYI 1387
    Length:1,387
    Mass (Da):148,403
    Last modified:June 28, 2011 - v2
    Checksum:i14340BC97D1427F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138821 Genomic DNA. No translation available.
    AL139082 Genomic DNA. No translation available.
    AL162377 Genomic DNA. No translation available.
    RefSeqiXP_005266484.1. XM_005266427.2.
    UniGeneiHs.492280.

    Genome annotation databases

    EnsembliENST00000448424; ENSP00000416738; ENSG00000123191.
    GeneIDi540.
    KEGGihsa:540.
    UCSCiuc010tgv.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138821 Genomic DNA. No translation available.
    AL139082 Genomic DNA. No translation available.
    AL162377 Genomic DNA. No translation available.
    RefSeqi XP_005266484.1. XM_005266427.2.
    UniGenei Hs.492280.

    3D structure databases

    ProteinModelPortali E7ET55.
    SMRi E7ET55. Positions 58-1301.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000448424 ; ENSP00000416738 ; ENSG00000123191 .
    GeneIDi 540.
    KEGGi hsa:540.
    UCSCi uc010tgv.1. human.

    Organism-specific databases

    CTDi 540.
    HGNCi HGNC:870. ATP7B.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K17686.

    Miscellaneous databases

    GenomeRNAii 540.
    NextBioi 35500287.

    Gene expression databases

    ArrayExpressi E7ET55.
    Bgeei E7ET55.

    Family and domain databases

    Gene3Di 2.70.150.10. 1 hit.
    3.40.1110.10. 2 hits.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR027256. Cation_transp_P-typ_ATPase_IB.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    IPR006122. HMA_Cu_ion-bd.
    [Graphical view ]
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    PF00403. HMA. 6 hits.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF55008. SSF55008. 6 hits.
    SSF56784. SSF56784. 2 hits.
    TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    TIGR00003. TIGR00003. 6 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    PS01047. HMA_1. 6 hits.
    PS50846. HMA_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7ET55_HUMAN
    AccessioniPrimary (citable) accession number: E7ET55
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3