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E7ESX1

- E7ESX1_HUMAN

UniProt

E7ESX1 - E7ESX1_HUMAN

Protein

Chordin

Gene

CHRD

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.UniRule annotation

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental proteinUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ChordinUniRule annotation
    Gene namesi
    Name:CHRDImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1949. CHRD.

    Expressioni

    Gene expression databases

    ArrayExpressiE7ESX1.
    BgeeiE7ESX1.

    Structurei

    3D structure databases

    ProteinModelPortaliE7ESX1.
    SMRiE7ESX1. Positions 48-129, 700-766, 780-855, 867-936.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chordin family.UniRule annotation

    Phylogenomic databases

    KOiK04657.

    Family and domain databases

    InterProiIPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07452. CHRD. 4 hits.
    PF00093. VWC. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002496. Chordin. 1 hit.
    SMARTiSM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view]
    PROSITEiPS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7ESX1-1 [UniParc]FASTAAdd to Basket

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    MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG    50
    CTFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK 100
    NIKPECPTPA CGQPRQLPGH CCQTCPQERS SSERQPSGLS FEYPRDPEHR 150
    SYSDRGEPGA EERARGDGHT DFVALLTGPR SQAVARARVS LLRSSLRFSI 200
    SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA VPRLSLRLLR 250
    AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI 300
    TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA 350
    NVSAQEPGFA EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR 400
    KSCDVLQSVL CGADALIPVQ TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV 450
    VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT AVGICPGLGA RGAHMLLQNE 500
    LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG ALVLPPVKSQ 550
    AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK 600
    GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ 650
    CEVGGLRLEA AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR 700
    DPNTCFFEGQ QRPHGARWAP NYDPLCSLCT CQRRTVICDP VVCPPPSCPH 750
    PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP GEGCYFDGDR SWRAAGTRWH 800
    PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR VNPTDCCKQC 850
    PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC 900
    RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPPE TRTDPELEKE 950
    AEGS 954
    Length:954
    Mass (Da):101,961
    Last modified:March 8, 2011 - v1
    Checksum:i557AC50B00D5AF14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC078797 Genomic DNA. No translation available.
    RefSeqiXP_005247907.1. XM_005247850.1.
    UniGeneiHs.166186.

    Genome annotation databases

    EnsembliENST00000450923; ENSP00000408972; ENSG00000090539.
    GeneIDi8646.
    KEGGihsa:8646.
    UCSCiuc003fox.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC078797 Genomic DNA. No translation available.
    RefSeqi XP_005247907.1. XM_005247850.1.
    UniGenei Hs.166186.

    3D structure databases

    ProteinModelPortali E7ESX1.
    SMRi E7ESX1. Positions 48-129, 700-766, 780-855, 867-936.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000450923 ; ENSP00000408972 ; ENSG00000090539 .
    GeneIDi 8646.
    KEGGi hsa:8646.
    UCSCi uc003fox.3. human.

    Organism-specific databases

    CTDi 8646.
    HGNCi HGNC:1949. CHRD.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K04657.

    Miscellaneous databases

    GenomeRNAii 8646.
    NextBioi 35500251.

    Gene expression databases

    ArrayExpressi E7ESX1.
    Bgeei E7ESX1.

    Family and domain databases

    InterProi IPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07452. CHRD. 4 hits.
    PF00093. VWC. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002496. Chordin. 1 hit.
    SMARTi SM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view ]
    PROSITEi PS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7ESX1_HUMAN
    AccessioniPrimary (citable) accession number: E7ESX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3