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Protein
Submitted name:

Adhesion G protein-coupled receptor L3

Gene

ADGRL3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor L3Imported
Gene namesi
Name:ADGRL3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:20974. ADGRL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei947 – 970HelicalSequence analysisAdd BLAST24
Transmembranei982 – 1000HelicalSequence analysisAdd BLAST19
Transmembranei1006 – 1028HelicalSequence analysisAdd BLAST23
Transmembranei1049 – 1069HelicalSequence analysisAdd BLAST21
Transmembranei1089 – 1112HelicalSequence analysisAdd BLAST24
Transmembranei1133 – 1156HelicalSequence analysisAdd BLAST24
Transmembranei1162 – 1185HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500321752120 – 1299Sequence analysisAdd BLAST1280

Proteomic databases

PaxDbiE7ESV6.
PeptideAtlasiE7ESV6.
PRIDEiE7ESV6.

Expressioni

Gene expression databases

BgeeiENSG00000150471.
ExpressionAtlasiE7ESV6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000422533.

Structurei

3D structure databases

ProteinModelPortaliE7ESV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 192SUEL-type lectinInterPro annotationAdd BLAST90
Domaini202 – 461Olfactomedin-likeInterPro annotationAdd BLAST260
Domaini566 – 622G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST57
Domaini883 – 934GPSInterPro annotationAdd BLAST52
Domaini945 – 1186G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation
Contains 1 SUEL-type lectin domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR015630. Latrophilin-3.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF60. PTHR12011:SF60. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7ESV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPSQLLIFM MLLAPIIHGG KHSERHPALA APLRHAERSP GGALPPRHLL
60 70 80 90 100
QQPAAERTAA HRGQGPRGAT RGVRGPGAQG AQIAAQAFSR APIPMAVVRR
110 120 130 140 150
ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD
160 170 180 190 200
AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV
210 220 230 240 250
FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL
260 270 280 290 300
TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD
310 320 330 340 350
LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN
360 370 380 390 400
GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN
410 420 430 440 450
EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY
460 470 480 490 500
HVVKYSLDFG PLDSRSGQAH HGQVSYISPP IHLDSELERP SVKDISTTGP
510 520 530 540 550
LGMGSTTTST TLRTTTLSPG RSTTPSVSGR RNRSTSTPSP AVEVLDDMTT
560 570 580 590 600
HLPSASSQIP ALEESCEAVE AREIMWFKTR QGQIAKQPCP AGTIGVSTYL
610 620 630 640 650
CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH
660 670 680 690 700
LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR
710 720 730 740 750
AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLHT VEESAFVLAD
760 770 780 790 800
NLLKTDIVRE NTDNIKLEVA RLSTEGNLED LKFPENMGHG STIQLSANTL
810 820 830 840 850
KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEALSTN HSVIVNSPVI
860 870 880 890 900
TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW
910 920 930 940 950
STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW
960 970 980 990 1000
VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN
1010 1020 1030 1040 1050
RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY
1060 1070 1080 1090 1100
FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII
1110 1120 1130 1140 1150
MLNVIFLGIA LYKMFHHTAI LKPESGCLDN IKSWVIGAIA LLCLLGLTWA
1160 1170 1180 1190 1200
FGLMYINEST VIMAYLFTIF NSLQGMFIFI FHCVLQKKVR KEYGKCLRTH
1210 1220 1230 1240 1250
CCSGKSTESS IGSGKTSGSR TPGRYSTGSQ SRIRRMWNDT VRKQSESSFI
1260 1270 1280 1290
TGDINSSASL NREPYRETSM GVKLNIAYQI GASEQCQGYK CHGYSTTEW
Length:1,299
Mass (Da):145,060
Last modified:March 8, 2011 - v1
Checksum:i5E25A32DC1FDD736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020741 Genomic DNA. No translation available.
AC092643 Genomic DNA. No translation available.
AC092668 Genomic DNA. No translation available.
AC096723 Genomic DNA. No translation available.
AC104813 Genomic DNA. No translation available.
AC108161 Genomic DNA. No translation available.
KF457762 Genomic DNA. No translation available.
KF457763 Genomic DNA. No translation available.
RefSeqiXP_016863430.1. XM_017007941.1.
UniGeneiHs.28391.
Hs.570770.

Genome annotation databases

EnsembliENST00000511324; ENSP00000425033; ENSG00000150471.
GeneIDi23284.
UCSCiuc062wxr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020741 Genomic DNA. No translation available.
AC092643 Genomic DNA. No translation available.
AC092668 Genomic DNA. No translation available.
AC096723 Genomic DNA. No translation available.
AC104813 Genomic DNA. No translation available.
AC108161 Genomic DNA. No translation available.
KF457762 Genomic DNA. No translation available.
KF457763 Genomic DNA. No translation available.
RefSeqiXP_016863430.1. XM_017007941.1.
UniGeneiHs.28391.
Hs.570770.

3D structure databases

ProteinModelPortaliE7ESV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000422533.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiE7ESV6.
PeptideAtlasiE7ESV6.
PRIDEiE7ESV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000511324; ENSP00000425033; ENSG00000150471.
GeneIDi23284.
UCSCiuc062wxr.1. human.

Organism-specific databases

HGNCiHGNC:20974. ADGRL3.
OpenTargetsiENSG00000150471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.

Miscellaneous databases

ChiTaRSiLPHN3. human.

Gene expression databases

BgeeiENSG00000150471.
ExpressionAtlasiE7ESV6. baseline and differential.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR015630. Latrophilin-3.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF60. PTHR12011:SF60. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7ESV6_HUMAN
AccessioniPrimary (citable) accession number: E7ESV6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.