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E7ESV6

- E7ESV6_HUMAN

UniProt

E7ESV6 - E7ESV6_HUMAN

Protein
Submitted name:

Latrophilin-3

Gene

LPHN3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptorSAAS annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Latrophilin-3Imported
    Gene namesi
    Name:LPHN3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:20974. LPHN3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiE7ESV6.

    Structurei

    3D structure databases

    ProteinModelPortaliE7ESV6.
    SMRiE7ESV6. Positions 93-197, 566-922, 947-1185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SUEL-type lectin domain.UniRule annotation
    Contains GPS domain.SAAS annotation
    Contains olfactomedin-like domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    OMAiFPLEFYK.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR015630. GPCR_2_latrophilin3.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view]
    PANTHERiPTHR12011:SF60. PTHR12011:SF60. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7ESV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWPSQLLIFM MLLAPIIHGG KHSERHPALA APLRHAERSP GGALPPRHLL     50
    QQPAAERTAA HRGQGPRGAT RGVRGPGAQG AQIAAQAFSR APIPMAVVRR 100
    ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD 150
    AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV 200
    FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL 250
    TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 300
    LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN 350
    GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN 400
    EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY 450
    HVVKYSLDFG PLDSRSGQAH HGQVSYISPP IHLDSELERP SVKDISTTGP 500
    LGMGSTTTST TLRTTTLSPG RSTTPSVSGR RNRSTSTPSP AVEVLDDMTT 550
    HLPSASSQIP ALEESCEAVE AREIMWFKTR QGQIAKQPCP AGTIGVSTYL 600
    CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH 650
    LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR 700
    AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLHT VEESAFVLAD 750
    NLLKTDIVRE NTDNIKLEVA RLSTEGNLED LKFPENMGHG STIQLSANTL 800
    KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEALSTN HSVIVNSPVI 850
    TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW 900
    STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW 950
    VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN 1000
    RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY 1050
    FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII 1100
    MLNVIFLGIA LYKMFHHTAI LKPESGCLDN IKSWVIGAIA LLCLLGLTWA 1150
    FGLMYINEST VIMAYLFTIF NSLQGMFIFI FHCVLQKKVR KEYGKCLRTH 1200
    CCSGKSTESS IGSGKTSGSR TPGRYSTGSQ SRIRRMWNDT VRKQSESSFI 1250
    TGDINSSASL NREPYRETSM GVKLNIAYQI GASEQCQGYK CHGYSTTEW 1299
    Length:1,299
    Mass (Da):145,060
    Last modified:March 8, 2011 - v1
    Checksum:i5E25A32DC1FDD736
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007511 Genomic DNA. No translation available.
    AC020741 Genomic DNA. No translation available.
    AC092643 Genomic DNA. No translation available.
    AC092663 Genomic DNA. No translation available.
    AC092668 Genomic DNA. No translation available.
    AC096723 Genomic DNA. No translation available.
    AC104813 Genomic DNA. No translation available.
    AC108161 Genomic DNA. No translation available.
    KF457762 Genomic DNA. No translation available.
    KF457763 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000511324; ENSP00000425033; ENSG00000150471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007511 Genomic DNA. No translation available.
    AC020741 Genomic DNA. No translation available.
    AC092643 Genomic DNA. No translation available.
    AC092663 Genomic DNA. No translation available.
    AC092668 Genomic DNA. No translation available.
    AC096723 Genomic DNA. No translation available.
    AC104813 Genomic DNA. No translation available.
    AC108161 Genomic DNA. No translation available.
    KF457762 Genomic DNA. No translation available.
    KF457763 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E7ESV6.
    SMRi E7ESV6. Positions 93-197, 566-922, 947-1185.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000511324 ; ENSP00000425033 ; ENSG00000150471 .

    Organism-specific databases

    HGNCi HGNC:20974. LPHN3.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi FPLEFYK.

    Miscellaneous databases

    ChiTaRSi LPHN3. human.
    NextBioi 35500244.

    Gene expression databases

    ArrayExpressi E7ESV6.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR015630. GPCR_2_latrophilin3.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view ]
    PANTHERi PTHR12011:SF60. PTHR12011:SF60. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7ESV6_HUMAN
    AccessioniPrimary (citable) accession number: E7ESV6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3