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Protein
Submitted name:

Cyclin-dependent kinase 2

Gene

CDK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE7ESI2.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin-dependent kinase 2Imported
Gene namesi
Name:CDK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1771. CDK2.

PTM / Processingi

Proteomic databases

MaxQBiE7ESI2.
PeptideAtlasiE7ESI2.
PRIDEiE7ESI2.

Expressioni

Gene expression databases

BgeeiENSG00000123374.
ExpressionAtlasiE7ESI2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7ESI2.
SMRiE7ESI2. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 226223Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00830000128256.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7ESI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL
60 70 80 90 100
YLVFEFLHQD LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR
110 120 130 140 150
DLKPQNLLIN TEGAIKLADF GLARAFGVPV RTYTHEVTRR ALFPGDSEID
160 170 180 190 200
QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR
210 220 230
SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Length:238
Mass (Da):27,165
Last modified:March 8, 2011 - v1
Checksum:i61415DADFE55CFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025162 Genomic DNA. No translation available.
AC034102 Genomic DNA. No translation available.
RefSeqiNP_001277159.1. NM_001290230.1.
UniGeneiHs.19192.
Hs.689624.

Genome annotation databases

EnsembliENST00000440311; ENSP00000393605; ENSG00000123374.
GeneIDi1017.
UCSCiuc010spy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025162 Genomic DNA. No translation available.
AC034102 Genomic DNA. No translation available.
RefSeqiNP_001277159.1. NM_001290230.1.
UniGeneiHs.19192.
Hs.689624.

3D structure databases

ProteinModelPortaliE7ESI2.
SMRiE7ESI2. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE7ESI2.
PeptideAtlasiE7ESI2.
PRIDEiE7ESI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000440311; ENSP00000393605; ENSG00000123374.
GeneIDi1017.
UCSCiuc010spy.3. human.

Organism-specific databases

CTDi1017.
HGNCiHGNC:1771. CDK2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00830000128256.

Enzyme and pathway databases

SignaLinkiE7ESI2.

Miscellaneous databases

ChiTaRSiCDK2. human.
GenomeRNAii1017.

Gene expression databases

BgeeiENSG00000123374.
ExpressionAtlasiE7ESI2. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7ESI2_HUMAN
AccessioniPrimary (citable) accession number: E7ESI2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.