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Protein
Submitted name:

Cyclin-dependent kinase 2

Gene

CDK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE7ESI2

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin-dependent kinase 2Imported
Gene namesi
Name:CDK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123374.10
HGNCiHGNC:1771 CDK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123374

PTM / Processingi

Proteomic databases

MaxQBiE7ESI2
PeptideAtlasiE7ESI2
PRIDEiE7ESI2

Expressioni

Gene expression databases

BgeeiENSG00000123374
ExpressionAtlasiE7ESI2 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiE7ESI2, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliE7ESI2
SMRiE7ESI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 226Protein kinaseInterPro annotationAdd BLAST223

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000144030

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E7ESI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL
60 70 80 90 100
YLVFEFLHQD LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR
110 120 130 140 150
DLKPQNLLIN TEGAIKLADF GLARAFGVPV RTYTHEVTRR ALFPGDSEID
160 170 180 190 200
QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR
210 220 230
SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Length:238
Mass (Da):27,165
Last modified:March 8, 2011 - v1
Checksum:i61415DADFE55CFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025162 Genomic DNA No translation available.
AC034102 Genomic DNA No translation available.
RefSeqiNP_001277159.1, NM_001290230.1
UniGeneiHs.19192
Hs.689624

Genome annotation databases

EnsembliENST00000440311; ENSP00000393605; ENSG00000123374
GeneIDi1017
UCSCiuc010spy.3 human

Similar proteinsi

Entry informationi

Entry nameiE7ESI2_HUMAN
AccessioniPrimary (citable) accession number: E7ESI2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health