Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Important for binding to LRP1UniRule annotation1
Active sitei294Charge relay systemUniRule annotation1
Active sitei343Charge relay systemUniRule annotation1
Sitei401Important for single-chain activityUniRule annotation1
Sitei449Important for single-chain activityUniRule annotation1
Active sitei450Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation
Biological processPlasminogen activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activatorUniRule annotation (EC:3.4.21.68UniRule annotation)
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9051. PLAT.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500321751323 – 499Plasminogen activatorSequence analysisAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 71UniRule annotation
Disulfide bondi69 ↔ 78UniRule annotation
Disulfide bondi86 ↔ 97UniRule annotation
Disulfide bondi91 ↔ 108UniRule annotation
Disulfide bondi110 ↔ 119UniRule annotation
Disulfide bondi152 ↔ 233UniRule annotation
Disulfide bondi173 ↔ 215UniRule annotation
Disulfide bondi204 ↔ 228UniRule annotation
Disulfide bondi236 ↔ 367Interchain (between A and B chains)UniRule annotation
Disulfide bondi279 ↔ 295UniRule annotation
Disulfide bondi287 ↔ 356UniRule annotation
Disulfide bondi381 ↔ 456UniRule annotation
Disulfide bondi413 ↔ 429UniRule annotation
Disulfide bondi446 ↔ 474UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

MaxQBiE7ESF4.
PaxDbiE7ESF4.
PeptideAtlasiE7ESF4.
PRIDEiE7ESF4.

Expressioni

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiE7ESF4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7ESF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini82 – 120EGF-likeInterPro annotationAdd BLAST39
Domaini151 – 233KringleInterPro annotationAdd BLAST83
Domaini248 – 498Peptidase S1InterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 52Important for binding to annexin A2UniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR026280. Tissue_plasm_act.
IPR034811. tPA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PANTHERiPTHR24256:SF341. PTHR24256:SF341. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001145. Tissue_plasm_act. 2 hits.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

E7ESF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA
110 120 130 140 150
LYFSDFVCQC PEGFAGKCCE IDSKPWCYVF KAGKYSSEFC STPACSEGNS
160 170 180 190 200
DCYFGNGSAY RGTHSLTESG ASCLPWNSMI LIGKVYTAQN PSAQALGLGK
210 220 230 240 250
HNYCRNPDGD AKPWCHVLKN RRLTWEYCDV PSCSTCGLRQ YSQPQFRIKG
260 270 280 290 300
GLFADIASHP WQAAIFAKHR RSPGERFLCG GILISSCWIL SAAHCFQERF
310 320 330 340 350
PPHHLTVILG RTYRVVPGEE EQKFEVEKYI VHKEFDDDTY DNDIALLQLK
360 370 380 390 400
SDSSRCAQES SVVRTVCLPP ADLQLPDWTE CELSGYGKHE ALSPFYSERL
410 420 430 440 450
KEAHVRLYPS SRCTSQHLLN RTVTDNMLCA GDTRSGGPQA NLHDACQGDS
460 470 480 490
GGPLVCLNDG RMTLVGIISW GLGCGQKDVP GVYTKVTNYL DWIRDNMRP
Length:499
Mass (Da):55,895
Last modified:March 8, 2011 - v1
Checksum:i7408BB2A554289A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000519510; ENSP00000428886; ENSG00000104368.
UCSCiuc064mjr.1. human.

Similar proteinsi

Entry informationi

Entry nameiE7ESF4_HUMAN
AccessioniPrimary (citable) accession number: E7ESF4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: August 30, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported