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Protein
Submitted name:

Nitric oxide synthase, endothelial

Gene

NOS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

HemeSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Nitric oxide synthase, endothelialImported
Gene namesi
Name:NOS3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7876. NOS3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164867.

PTM / Processingi

Proteomic databases

MaxQBiE7ESA7.
PaxDbiE7ESA7.
PeptideAtlasiE7ESA7.
PRIDEiE7ESA7.

Expressioni

Gene expression databases

BgeeiENSG00000164867.
ExpressionAtlasiE7ESA7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297494.

Structurei

3D structure databases

ProteinModelPortaliE7ESA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini314 – 497Flavodoxin-likeInterPro annotationAdd BLAST184
Domaini550 – 796FAD-binding FR-typeInterPro annotationAdd BLAST247

Phylogenomic databases

eggNOGiKOG1158. Eukaryota.
COG0369. LUCA.
COG4362. LUCA.
GeneTreeiENSGT00840000129757.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_dom.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000333. NOS. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7ESA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTYICNHIK YATNRGNLRS AITVFPQRCP GRGDFRIWNS QLVRYAGYRQ
60 70 80 90 100
QDGSVRGDPA NVEITELCIQ HGWTPGNGRF DVLPLLLQAP DDPPELFLLP
110 120 130 140 150
PELVLEVPLE HPTLEWFAAL GLRWYALPAV SNMLLEIGGL EFPAAPFSGW
160 170 180 190 200
YMSTEIGTRN LCDPHRYNIL EDVAVCMDLD TRTTSSLWKD KAAVEINVAV
210 220 230 240 250
LHSYQLAKVT IVDHHAATAS FMKHLENEQK ARGGCPADWA WIVPPISGSL
260 270 280 290 300
TPVFHQEMVN YFLSPAFRYQ PDPWKGSAAK GTGITRKKTF KEVANAVKIS
310 320 330 340 350
ASLMGTVMAK RVKATILYGS ETGRAQSYAQ QLGRLFRKAF DPRVLCMDEY
360 370 380 390 400
DVVSLEHETL VLVVTSTFGN GDPPENGESF AAALMEMSGP YNSSPRPEQH
410 420 430 440 450
KSYKIRFNSI SCSDPLVSSW RRKRKESSNT DSAGALGTLR FCVFGLGSRA
460 470 480 490 500
YPHFCAFARA VDTRLEELGG ERLLQLGQGD ELCGQEEAFR GWAQAAFQAA
510 520 530 540 550
CETFCVGEDA KAAARDIFSP KRSWKRQRYR LSAQAEGLQL LPGLIHVHRR
560 570 580 590 600
KMFQATIRSV ENLQSSKSTR ATILVRLDTG GQEGLQYQPG DHIGVCPPNR
610 620 630 640 650
PGLVEALLSR VEDPPAPTEP VAVEQLEKGS PGGPPPGWVR DPRLPPCTLR
660 670 680 690 700
QALTFFLDIT SPPSPQLLRL LSTLAEEPRE QQELEALSQD PRRYEEWKWF
710 720 730 740 750
RCPTLLEVLE QFPSVALPAP LLLTQLPLLQ PRYYSVSSAP STHPGEIHLT
760 770 780 790 800
VAVLAYRTQD GLGPLHYGVC STWLSQLKPG DPVPCFIRGA PSFRLPPDPS
810 820 830 840 850
LPCILVGPGT GIAPFRGFWQ ERLHDIESKG LQPTPMTLVF GCRCSQLDHL
860 870 880 890 900
YRDEVQNAQQ RGVFGRVLTA FSREPDNPKT YVQDILRTEL AAEVHRVLCL
910 920 930 940 950
ERGHMFVCGD VTMATNVLQT VQRILATEGD MELDEAGDVI GVLRDQQRYH
960 970 980 990
EDIFGLTLRT QEVTSRIRTQ SFSLQERQLR GAVPWAFDPP GSDTNSP
Length:997
Mass (Da):111,122
Last modified:March 8, 2011 - v1
Checksum:i140BAE02024A22D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010973 Genomic DNA. No translation available.
RefSeqiXP_016867722.1. XM_017012233.1.
UniGeneiHs.647092.

Genome annotation databases

EnsembliENST00000461406; ENSP00000417143; ENSG00000164867.
GeneIDi4846.
UCSCiuc011kuy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010973 Genomic DNA. No translation available.
RefSeqiXP_016867722.1. XM_017012233.1.
UniGeneiHs.647092.

3D structure databases

ProteinModelPortaliE7ESA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297494.

Proteomic databases

MaxQBiE7ESA7.
PaxDbiE7ESA7.
PeptideAtlasiE7ESA7.
PRIDEiE7ESA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000461406; ENSP00000417143; ENSG00000164867.
GeneIDi4846.
UCSCiuc011kuy.3. human.

Organism-specific databases

HGNCiHGNC:7876. NOS3.
OpenTargetsiENSG00000164867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1158. Eukaryota.
COG0369. LUCA.
COG4362. LUCA.
GeneTreeiENSGT00840000129757.

Miscellaneous databases

ChiTaRSiNOS3. human.

Gene expression databases

BgeeiENSG00000164867.
ExpressionAtlasiE7ESA7. baseline and differential.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_dom.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000333. NOS. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7ESA7_HUMAN
AccessioniPrimary (citable) accession number: E7ESA7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.