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Protein
Submitted name:

Focal adhesion kinase 1

Gene

PTK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Focal adhesion kinase 1Imported
Gene namesi
Name:PTK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169398.19
HGNCiHGNC:9611 PTK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169398

Expressioni

Gene expression databases

BgeeiENSG00000169398

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 399FERMInterPro annotationAdd BLAST321
Domaini466 – 724Protein kinaseInterPro annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili261 – 281Sequence analysisAdd BLAST21
Coiled coili721 – 741Sequence analysisAdd BLAST21
Coiled coili853 – 873Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4257 Eukaryota
ENOG410ZH9Y LUCA
GeneTreeiENSGT00760000118799
OMAiVQTNHYQ
OrthoDBiEOG091G03BN

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR036137 Focal_adhe_kin_target_dom_sf
IPR005189 Focal_adhesion_kin_target_dom
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF03623 Focal_AT, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006413 Focal_adhesion_target_reg, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF68993 SSF68993, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

E7ESA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLELAGQEA LKPAGAIYME KSGCSPFPVC WAKEYDRYLA SSKIMAAAYL
60 70 80 90 100
DPNLNHTPNS STKTHLGTGM ERSPGAMERV LKVFHYFESN SEPTTWASII
110 120 130 140 150
RHGDATDVRG IIQKIVDSHK VKHVACYGFR LSHLRSEEVH WLHVDMGVSS
160 170 180 190 200
VREKYELAHP PEEWKYELRI RYLPKGFLNQ FTEDKPTLNF FYQQVKSDYM
210 220 230 240 250
LEIADQVDQE IALKLGCLEI RRSYWEMRGN ALEKKSNYEV LEKDVGLKRF
260 270 280 290 300
FPKSLLDSVK AKTLRKLIQQ TFRQFANLNR EESILKFFEI LSPVYRFDKE
310 320 330 340 350
CFKCALGSSW IISVELAIGP EEGISYLTDK GCNPTHLADF TQVQTIQYSN
360 370 380 390 400
SEDKDRKGML QLKIAGAPEP LTVTAPSLTI AENMADLIDG YCRLVNGTSQ
410 420 430 440 450
SFIIRPQKEG ERALPSIPKL ANSEKQGMRT HAVSVSETDD YAEIIDEEDT
460 470 480 490 500
YTMPSTRDYE IQRERIELGR CIGEGQFGDV HQGIYMSPEN PALAVAIKTC
510 520 530 540 550
KNCTSDSVRE KFLQEALTMR QFDHPHIVKL IGVITENPVW IIMELCTLGE
560 570 580 590 600
LRSFLQVRKY SLDLASLILY AYQLSTALAY LESKRFVHRD IAARNVLVSS
610 620 630 640 650
NDCVKLGDFG LSRYMEDSTY YKASKGKLPI KWMAPESINF RRFTSASDVW
660 670 680 690 700
MFGVCMWEIL MHGVKPFQGV KNNDVIGRIE NGERLPMPPN CPPTLYSLMT
710 720 730 740 750
KCWAYDPSRR PRFTELKAQL STILEEEKAQ QEERMRMESR RQATVSWDSG
760 770 780 790 800
GSDEAPPKPS RPGYPSPRSS EGFYPSPQHM VQTNHYQVSG YPGSHGITAM
810 820 830 840 850
AGSIYPGQAS LLDQTDSWNH RPQEIAMWQP NVEDSTVLDL RGIGQVLPTH
860 870 880 890 900
LMEERLIRQQ QEMEEDQRWL EKEERFLKPD VRLSRGSIDR EDGSLQGPIG
910 920 930 940 950
NQHIYQPVGK PDPAAPPKKP PRPGAPGHLG SLASLSSPAD SYNEGVKLQP
960 970 980 990 1000
QEISPPPTAN LDRSNDKVYE NVTGLVKAVI EMSSKIQPAP PEEYVPMVKE
1010 1020 1030 1040 1050
VGLALRTLLA TVDETIPLLP ASTHREIEMA QKLLNSDLGE LINKMKLAQQ
1060 1070 1080 1090
YVMTSLQQEY KKQMLTAAHA LAVDAKNLLD VIDQARLKML GQTRPH
Length:1,096
Mass (Da):124,082
Last modified:March 8, 2011 - v1
Checksum:iCF501C4E502A14DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067931 Genomic DNA No translation available.
AC100860 Genomic DNA No translation available.
AC105009 Genomic DNA No translation available.
AC105235 Genomic DNA No translation available.
KF458878 Genomic DNA No translation available.
KF458882 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000517887; ENSP00000429082; ENSG00000169398
ENST00000519419; ENSP00000429129; ENSG00000169398
UCSCiuc064qqo.1 human

Similar proteinsi

Entry informationi

Entry nameiE7ESA6_HUMAN
AccessioniPrimary (citable) accession number: E7ESA6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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