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E7ES19

- E7ES19_HUMAN

UniProt

E7ES19 - E7ES19_HUMAN

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Protein
Submitted name:

Thrombospondin-4

Gene

THBS4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. behavioral response to pain Source: Ensembl
  2. cell adhesion Source: InterPro
  3. regulation of tissue remodeling Source: Ensembl
  4. response to endoplasmic reticulum stress Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin-4Imported
Gene namesi
Name:THBS4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11788. THBS4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: Ensembl
  3. sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiE7ES19.
ExpressionAtlasiE7ES19. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7ES19.
SMRiE7ES19. Positions 127-171, 199-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074507.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PfamiPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 2 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7ES19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRLNKAILR YLKNDGKVHL VVFNNLQLAD GRRHRILLRL SNLQRGAGSL
60 70 80 90 100
ELYLDCIQVD SVHNLPRAFA GPSQKPETIE LRTFQRKPQD FLEELKLVVR
110 120 130 140 150
GSLFQVASLQ DCFLQQSEPL AATGTGDFNR QFLGQMTQLN QLLGEVKDLL
160 170 180 190 200
RQQVKETSFL RNTIAECQAC GPLKFQSPTP STVVPPAPPA PPTRPPRRCD
210 220 230 240 250
SNPCFRGVQC TDSRDGFQCG PCPEGYTGNG ITCIDVDECK YHPCYPGVHC
260 270 280 290 300
INLSPGFRCD ACPVGFTGPM VQGVGISFAK SNKQVCTDID ECRNGACVPN
310 320 330 340 350
SICVNTLGSY RCGPCKPGYT GDQIRGCKAE RNCRNPELNP CSVNAQCIEE
360 370 380 390 400
RQGDVTCVCG VGWAGDGYIC GKDVDIDSYP DEELPCSARN CKKDNCKYVP
410 420 430 440 450
NSGQEDADRD GIGDACDEDA DGDGILNEQD NCVLIHNVDQ RNSDKDIFGD
460 470 480 490 500
ACDNCLSVLN NDQKDTDGDG RGDACDDDMD GDGIKNILDN CPKFPNRDQR
510 520 530 540 550
DKDGDGVGDA CDSCPDVSNP NQSDVDNDLV GDSCDTNQDS DGDGHQDSTD
560 570 580 590 600
NCPTVINSAQ LDTDKDGIGD ECDDDDDNDG IPDLVPPGPD NCRLVPNPAQ
610 620 630 640 650
EDSNSDGVGD ICESDFDQDQ VIDRIDVCPE NAEVTLTDFR AYQTVVLDPE
660 670 680 690 700
GDAQIDPNWV VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTQT
710 720 730 740 750
DDDYAGFIFG YQDSSSFYVV MWKQTEQTYW QATPFRAVAE PGIQLKAVKS
760 770 780 790 800
KTGPGEHLRN SLWHTGDTSD QVRLLWKDSR NVGWKDKVSY RWFLQHRPQV
810 820 830 840 850
GYIRVRFYEG SELVADSGVT IDTTMRGGRL GVFCFSQENI IWSNLKYRCN
860 870
DTIPEDFQEF QTQNFDRFDN
Length:870
Mass (Da):96,006
Last modified:March 8, 2011 - v1
Checksum:i03F25B1B5FC43A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012636 Genomic DNA. No translation available.
AC112184 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000511733; ENSP00000422298; ENSG00000113296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012636 Genomic DNA. No translation available.
AC112184 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E7ES19.
SMRi E7ES19. Positions 127-171, 199-861.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000511733 ; ENSP00000422298 ; ENSG00000113296 .

Organism-specific databases

HGNCi HGNC:11788. THBS4.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00550000074507.

Miscellaneous databases

NextBioi 35500124.

Gene expression databases

Bgeei E7ES19.
ExpressionAtlasi E7ES19. baseline and differential.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
Pfami PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 2 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7ES19_HUMAN
AccessioniPrimary (citable) accession number: E7ES19
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3