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Protein
Submitted name:

Thrombospondin-4

Gene

THBS4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin-4Imported
Gene namesi
Name:THBS4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113296.14
HGNCiHGNC:11788 THBS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113296

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiE7ES19
PRIDEiE7ES19

Expressioni

Gene expression databases

BgeeiENSG00000113296
ExpressionAtlasiE7ES19 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7ES19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 234EGF-likeInterPro annotationAdd BLAST40
Domaini235 – 272EGF-likeInterPro annotationAdd BLAST38
Domaini288 – 328EGF-likeInterPro annotationAdd BLAST41
Domaini329 – 371EGF-likeInterPro annotationAdd BLAST43
Repeati372 – 404TSP type-3PROSITE-ProRule annotationAdd BLAST33
Repeati405 – 440TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati441 – 463TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati464 – 499TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati500 – 522TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati523 – 560TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati561 – 600TSP type-3PROSITE-ProRule annotationAdd BLAST40
Repeati601 – 636TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini640 – 854TSP C-terminalInterPro annotationAdd BLAST215

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00850000132273

Family and domain databases

Gene3Di4.10.1080.10, 3 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G
IPR024665 Thbs/COMP_coiled-coil
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR028974 TSP_type-3_rpt
PANTHERiPTHR10199 PTHR10199, 1 hit
PfamiView protein in Pfam
PF11598 COMP, 1 hit
PF07645 EGF_CA, 2 hits
PF02412 TSP_3, 6 hits
PF05735 TSP_C, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 3 hits
SM00210 TSPN, 1 hit
SUPFAMiSSF103647 SSF103647, 2 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

E7ES19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLNKAILR YLKNDGKVHL VVFNNLQLAD GRRHRILLRL SNLQRGAGSL
60 70 80 90 100
ELYLDCIQVD SVHNLPRAFA GPSQKPETIE LRTFQRKPQD FLEELKLVVR
110 120 130 140 150
GSLFQVASLQ DCFLQQSEPL AATGTGDFNR QFLGQMTQLN QLLGEVKDLL
160 170 180 190 200
RQQVKETSFL RNTIAECQAC GPLKFQSPTP STVVPPAPPA PPTRPPRRCD
210 220 230 240 250
SNPCFRGVQC TDSRDGFQCG PCPEGYTGNG ITCIDVDECK YHPCYPGVHC
260 270 280 290 300
INLSPGFRCD ACPVGFTGPM VQGVGISFAK SNKQVCTDID ECRNGACVPN
310 320 330 340 350
SICVNTLGSY RCGPCKPGYT GDQIRGCKAE RNCRNPELNP CSVNAQCIEE
360 370 380 390 400
RQGDVTCVCG VGWAGDGYIC GKDVDIDSYP DEELPCSARN CKKDNCKYVP
410 420 430 440 450
NSGQEDADRD GIGDACDEDA DGDGILNEQD NCVLIHNVDQ RNSDKDIFGD
460 470 480 490 500
ACDNCLSVLN NDQKDTDGDG RGDACDDDMD GDGIKNILDN CPKFPNRDQR
510 520 530 540 550
DKDGDGVGDA CDSCPDVSNP NQSDVDNDLV GDSCDTNQDS DGDGHQDSTD
560 570 580 590 600
NCPTVINSAQ LDTDKDGIGD ECDDDDDNDG IPDLVPPGPD NCRLVPNPAQ
610 620 630 640 650
EDSNSDGVGD ICESDFDQDQ VIDRIDVCPE NAEVTLTDFR AYQTVVLDPE
660 670 680 690 700
GDAQIDPNWV VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTQT
710 720 730 740 750
DDDYAGFIFG YQDSSSFYVV MWKQTEQTYW QATPFRAVAE PGIQLKAVKS
760 770 780 790 800
KTGPGEHLRN SLWHTGDTSD QVRLLWKDSR NVGWKDKVSY RWFLQHRPQV
810 820 830 840 850
GYIRVRFYEG SELVADSGVT IDTTMRGGRL GVFCFSQENI IWSNLKYRCN
860 870
DTIPEDFQEF QTQNFDRFDN
Length:870
Mass (Da):96,006
Last modified:March 8, 2011 - v1
Checksum:i03F25B1B5FC43A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012636 Genomic DNA No translation available.
AC112184 Genomic DNA No translation available.
RefSeqiNP_001293141.1, NM_001306212.1
NP_001293142.1, NM_001306213.1
NP_001293143.1, NM_001306214.1
UniGeneiHs.211426

Genome annotation databases

EnsembliENST00000511733; ENSP00000422298; ENSG00000113296
GeneIDi7060
UCSCiuc063exh.1 human

Similar proteinsi

Entry informationi

Entry nameiE7ES19_HUMAN
AccessioniPrimary (citable) accession number: E7ES19
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health