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Protein
Submitted name:

Neurexin-1-beta

Gene

NRXN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1-betaImported
Gene namesi
Name:NRXN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8008. NRXN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1433 – 145321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 15071482Sequence analysisPRO_5003219291Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiE7ERL8.

Expressioni

Gene expression databases

BgeeiE7ERL8.
ExpressionAtlasiE7ERL8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385142.

Structurei

3D structure databases

ProteinModelPortaliE7ERL8.
SMRiE7ERL8. Positions 279-468, 716-899, 904-1328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 217188LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini219 – 25638EGF-likeInterPro annotationAdd
BLAST
Domaini283 – 473191LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini480 – 672193LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini676 – 71338EGF-likeInterPro annotationAdd
BLAST
Domaini718 – 891174LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini905 – 1080176LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini1083 – 112038EGF-likeInterPro annotationAdd
BLAST
Domaini1126 – 1324199LAM_G_DOMAINInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 3 hits.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7ERL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLADTPVN DGAWHSVRIR RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQVLPVDSG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP
310 320 330 340 350
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA
360 370 380 390 400
FEALVEPVNG KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY
410 420 430 440 450
TQEDYTMLGS DDFFYVGGSP STADLPGSPV SNNFMGCLKE VVYKNNDVRL
460 470 480 490 500
ELSRLAKQGD PKMKIHGVVA FKCENVATLD PITFETPESF ISLPKWNAKK
510 520 530 540 550
TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF FAIEMLDGHL
560 570 580 590 600
YLLLDMGSGT IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA
610 620 630 640 650
PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID
660 670 680 690 700
GQSKDIRQMA EVQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC
710 720 730 740 750
DCSGTGYLGR SCEREATVLS YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR
760 770 780 790 800
AYGILMATTS RDSADTLRLE LDAGRVKLTV NLDCIRINCN SSKGPETLFA
810 820 830 840 850
GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT RLEFHNIETG
860 870 880 890 900
IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR
910 920 930 940 950
NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN
960 970 980 990 1000
DFIVVELVKG YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL
1010 1020 1030 1040 1050
HTVKIDTKIT TQITAGARNL DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ
1060 1070 1080 1090 1100
GCLASVDLNG RLPDLISDAL FCNGQIERGC EGPSTTCQED SCSNQGVCLQ
1110 1120 1130 1140 1150
QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP PNDRPSTRAD
1160 1170 1180 1190 1200
RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI
1210 1220 1230 1240 1250
EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG NNDNERLAIA
1260 1270 1280 1290 1300
RQRIPYRLGR VVDEWLLDKG RQLTIFNSQA TIIIGGKEQG QPFQGQLSGL
1310 1320 1330 1340 1350
YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA TAMQSEMSTS
1360 1370 1380 1390 1400
IMETTTTLAT STARRGKPPT KEPISQTTDD ILVASAECPS DDEDIDPCEP
1410 1420 1430 1440 1450
SSGGLANPTR AGGREPYPGS AEVIRESSST TGMVVGIVAA AALCILILLY
1460 1470 1480 1490 1500
AMYKYRNRDE GSYHVDESRN YISNSAQSNG AVVKEKQPSS AKSSNKNKKN

KDKEYYV
Length:1,507
Mass (Da):165,446
Last modified:March 8, 2011 - v1
Checksum:iD1716CC37589747E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
RefSeqiXP_011531473.1. XM_011533171.1.
UniGeneiHs.637685.

Genome annotation databases

EnsembliENST00000401669; ENSP00000385017; ENSG00000179915.
GeneIDi9378.
UCSCiuc061jbg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
RefSeqiXP_011531473.1. XM_011533171.1.
UniGeneiHs.637685.

3D structure databases

ProteinModelPortaliE7ERL8.
SMRiE7ERL8. Positions 279-468, 716-899, 904-1328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385142.

Proteomic databases

PaxDbiE7ERL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401669; ENSP00000385017; ENSG00000179915.
GeneIDi9378.
UCSCiuc061jbg.1. human.

Organism-specific databases

CTDi9378.
HGNCiHGNC:8008. NRXN1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.

Miscellaneous databases

ChiTaRSiNRXN1. human.
GenomeRNAii9378.
NextBioi35500063.

Gene expression databases

BgeeiE7ERL8.
ExpressionAtlasiE7ERL8. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 3 hits.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7ERL8_HUMAN
AccessioniPrimary (citable) accession number: E7ERL8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 11, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.