E7ERJ0 (E7ERJ0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Intersectin-1 Ensembl ENSP00000382290

Gene names

Name:

ITSN1 Ensembl ENSP00000382290

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000382290

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1178 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 5 SH3 domains. RuleBase RU003338
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000382290

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: InterPro
Cellular_component	plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E7ERJ0 [UniParc]. Last modified March 8, 2011. Version 1. Checksum: A344C5964504BDB1	FASTA	1,178	133,560
	10 20 30 40 50 60 MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 70 80 90 100 110 120 IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFAAVPP 130 140 150 160 170 180 LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV 190 200 210 220 230 240 PQSSRLKYRQ LFNSHDKTMS GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE 250 260 270 280 290 300 EFILAMHLID VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 310 320 330 340 350 360 EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE RAEQERKERE 370 380 390 400 410 420 RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA KRELERQRQL EWERNRRQEL 430 440 450 460 470 480 LNQRNKEQED IVVLKAKKKT LEFELEALND KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR 490 500 510 520 530 540 ELRIAEITHL QQQLQESQQM LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL 550 560 570 580 590 600 ARQHLRDQLD EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 610 620 630 640 650 660 KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES VKKKDGEEKG 670 680 690 700 710 720 KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ ENVKVVYYRA LYPFESRSHD 730 740 750 760 770 780 EITIQPGDIV MVDESQTGEP GWLGGELKGK TGWFPANYAE KIPENEVPAP VKPVTDSTSA 790 800 810 820 830 840 PAPKLALRET PAPLAVTSSE PSTTPNNWAD FSSTWPTSTN EKPETDNWDA WAAQPSLTVP 850 860 870 880 890 900 SAGQLRQRSA FTPATATGSS PSPVLGQGEK VEGLQAQALY PWRAKKDNHL NFNKNDVITV 910 920 930 940 950 960 LEQQDMWWFG EVQGQKGWFP KSYVKLISGP IRKSTSMDSG SSESPASLKR VASPAAKPVV 970 980 990 1000 1010 1020 SGEEFIAMYT YESSEQGDLT FQQGDVILVT KKDGDWWTGT VGDKAGVFPS NYVRLKDSEG 1030 1040 1050 1060 1070 1080 SGTAGKTGSL GKKPEIAQVI ASYTATGPEQ LTLAPGQLIL IRKKNPGGWW EGELQARGKK 1090 1100 1110 1120 1130 1140 RQIGWFPANY VKLLSPGTSK ITPTEPPKST ALAAVCQVIG MYDYTAQNDD ELAFNKGQII 1150 1160 1170 NVLNKEDPDW WKGEVNGQVG LFPSNYVKLT TDMDPSQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 21." Chromosome 21 mapping and sequencing consortium Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000308 Genomic DNA. No translation available. AP000309 Genomic DNA. No translation available. AP000310 Genomic DNA. No translation available. AP000311 Genomic DNA. No translation available. AP000312 Genomic DNA. No translation available. AP000313 Genomic DNA. No translation available.
IPI	IPI00451616.
3D structure databases
ProteinModelPortal	E7ERJ0.
SMR	E7ERJ0. Positions 1-111, 173-275, 708-793, 871-1178.
ModBase	Search...
Proteomic databases
PRIDE	E7ERJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000399353; ENSP00000382290; ENSG00000205726.
UCSC	uc002ysx.3. human.
Organism-specific databases
HGNC	HGNC:6183. ITSN1.
GenAtlas	Search...
Gene expression databases
ArrayExpress	E7ERJ0.
Bgee	E7ERJ0.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR000261. EPS15_homology. IPR026813. ITSN1. IPR011511. SH3_2. IPR001452. SH3_domain. IPR013315. Spectrin_alpha_SH3. [Graphical view]
PANTHER	PTHR11216:SF28. PTHR11216:SF28. 1 hit.
Pfam	PF00018. SH3_1. 3 hits. PF07653. SH3_2. 2 hits. [Graphical view]
PRINTS	PR00452. SH3DOMAIN. PR01887. SPECTRNALPHA.
SMART	SM00054. EFh. 2 hits. SM00027. EH. 2 hits. SM00326. SH3. 5 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 5 hits.
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS50031. EH. 2 hits. PS50002. SH3. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35500045.

Entry information

Entry name

E7ERJ0_HUMAN

Accession

Primary (citable) accession number: E7ERJ0

Entry history

Integrated into UniProtKB/TrEMBL:	March 8, 2011
Last sequence update:	March 8, 2011
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.