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Protein
Submitted name:

T-cell differentiation antigen CD6

Gene

CD6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
T-cell differentiation antigen CD6Imported
Gene namesi
Name:CD6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1691. CD6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei298 – 323HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000013725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500321732118 – 422Sequence analysisAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi230 ↔ 240PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiE7ER04.
PeptideAtlasiE7ER04.
PRIDEiE7ER04.

Expressioni

Gene expression databases

BgeeiENSG00000013725.
ExpressionAtlasiE7ER04. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7ER04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 156SRCRInterPro annotationAdd BLAST112
Domaini161 – 260SRCRInterPro annotationAdd BLAST100

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IK9E. Eukaryota.
ENOG410YC2B. LUCA.
GeneTreeiENSGT00870000136382.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiView protein in InterPro
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
PfamiView protein in Pfam
PF00530. SRCR. 2 hits.
PRINTSiPR00258. SPERACTRCPTR.
SMARTiView protein in SMART
SM00202. SR. 2 hits.
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiView protein in PROSITE
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

E7ER04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG
60 70 80 90 100
SSSCSGTVEV RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP
110 120 130 140 150
TPELPPPPAA GNTSVAANAT LAGAPALLCS GAEWRLCEVV EHACRSDGRR
160 170 180 190 200
ARVTCAENRA LRLVDGGGAC AGRVEMLEHG EWGSVCDDTW DLEDAHVVCR
210 220 230 240 250
QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC PGLPGQHYCG
260 270 280 290 300
HKEDAGAVCS ASRSLHNLST PEVPASVQTV TIESSVTVKI ENKESRELML
310 320 330 340 350
LIPSIVLGIL LLGSLIFIAF ILLRIKGKYV FMLPIQVQAP PPEDSDSGSD
360 370 380 390 400
SDYEHYDFSA QPPVALTTFY NSQRHRVTDE EVQQSRFQMP PLEEGLEELH
410 420
ASHIPTANPG HCITDPPSLG PQ
Length:422
Mass (Da):45,002
Last modified:June 28, 2011 - v2
Checksum:i4922D909FB5D007C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei422Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003721 Genomic DNA. No translation available.
KF455397 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000433107; ENSP00000410638; ENSG00000013725.
UCSCiuc058bxe.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE7ER04_HUMAN
AccessioniPrimary (citable) accession number: E7ER04
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported