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Protein
Submitted name:

Dystrophin

Gene

DMD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiE7EQR9

Names & Taxonomyi

Protein namesi
Submitted name:
DystrophinImported
Gene namesi
Name:DMDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198947.15
HGNCiHGNC:2928 DMD

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198947

PTM / Processingi

Proteomic databases

PeptideAtlasiE7EQR9
PRIDEiE7EQR9

Expressioni

Gene expression databases

BgeeiENSG00000198947
ExpressionAtlasiE7EQR9 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE7EQR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 359WWInterPro annotationAdd BLAST34
Domaini578 – 625ZZ-typeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 29Sequence analysisAdd BLAST21
Coiled coili193 – 227Sequence analysisAdd BLAST35
Coiled coili767 – 801Sequence analysisAdd BLAST35
Coiled coili840 – 874Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119237

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR016344 Dystrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PANTHERiPTHR44318:SF1 PTHR44318:SF1, 1 hit
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 1 hit
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00150 SPEC, 2 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

E7EQR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHRKTYHVK DLQGEIEAHT DVYHNLDENS QKILRSLEGS DDAVLLQRRL
60 70 80 90 100
DNMNFKWSEL RKKSLNIRSH LEASSDQWKR LHLSLQELLV WLQLKDDELS
110 120 130 140 150
RQAPIGGDFP AVQKQNDVHR AFKRELKTKE PVIMSTLETV RIFLTEQPLE
160 170 180 190 200
GLEKLYQEPR ELPPEERAQN VTRLLRKQAE EVNTEWEKLN LHSADWQRKI
210 220 230 240 250
DETLERLREL QEATDELDLK LRQAEVIKGS WQPVGDLLID SLQDHLEKVK
260 270 280 290 300
ALRGEIAPLK ENVSHVNDLA RQLTTLGIQL SPYNLSTLED LNTRWKLLQV
310 320 330 340 350
AVEDRVRQLH EAHRDFGPAS QHFLSTSVQG PWERAISPNK VPYYINHETQ
360 370 380 390 400
TTCWDHPKMT ELYQSLADLN NVRFSAYRTA MKLRRLQKAL CLDLLSLSAA
410 420 430 440 450
CDALDQHNLK QNDQPMDILQ IINCLTTIYD RLEQEHNNLV NVPLCVDMCL
460 470 480 490 500
NWLLNVYDTG RTGRIRVLSF KTGIISLCKA HLEDKYRYLF KQVASSTGFC
510 520 530 540 550
DQRRLGLLLH DSIQIPRQLG EVASFGGSNI EPSVRSCFQF ANNKPEIEAA
560 570 580 590 600
LFLDWMRLEP QSMVWLPVLH RVAAAETAKH QAKCNICKEC PIIGFRYRSL
610 620 630 640 650
KHFNYDICQS CFFSGRVAKG HKMHYPMVEY CTPTTSGEDV RDFAKVLKNK
660 670 680 690 700
FRTKRYFAKH PRMGYLPVQT VLEGDNMETP VTLINFWPVD SAPASSPQLS
710 720 730 740 750
HDDTHSRIEH YASRLAEMEN SNGSYLNDSI SPNESIDDEH LLIQHYCQSL
760 770 780 790 800
NQDSPLSQPR SPAQILISLE SEERGELERI LADLEEENRN LQAEYDRLKQ
810 820 830 840 850
QHEHKGLSPL PSPPEMMPTS PQSPRDAELI AEAKLLRQHK GRLEARMQIL
860 870 880 890 900
EDHNKQLESQ LHRLRQLLEQ PQAEAKVNGT TVSSPSTSLQ RSDSSQPMLL
910 920 930 940 950
RVVGSQTSDS MGEEDLLSPP QDTSTGLEEV MEQLNNSFPS SRGRNTPGKP

MREDTM
Length:956
Mass (Da):109,970
Last modified:October 29, 2014 - v2
Checksum:iDAC50E561ACEE305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006061 Genomic DNA No translation available.
AC078957 Genomic DNA No translation available.
AC078958 Genomic DNA No translation available.
AC079143 Genomic DNA No translation available.
AC079175 Genomic DNA No translation available.
AC079177 Genomic DNA No translation available.
AC079864 Genomic DNA No translation available.
AC090632 Genomic DNA No translation available.
AC093167 Genomic DNA No translation available.
AC093193 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000343523; ENSP00000340057; ENSG00000198947
UCSCiuc004dcq.1 human

Similar proteinsi

Entry informationi

Entry nameiE7EQR9_HUMAN
AccessioniPrimary (citable) accession number: E7EQR9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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