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Protein
Submitted name:

T-complex protein 1 subunit alpha

Gene

TCP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
T-complex protein 1 subunit alphaImported
Gene namesi
Name:TCP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11655. TCP1.

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120438.

PTM / Processingi

Proteomic databases

MaxQBiE7EQR6.
PaxDbiE7EQR6.
PeptideAtlasiE7EQR6.
PRIDEiE7EQR6.

PTM databases

iPTMnetiE7EQR6.

Expressioni

Gene expression databases

BgeeiENSG00000120438.
ExpressionAtlasiE7EQR6. baseline and differential.
GenevisibleiE7EQR6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317334.

Structurei

3D structure databases

ProteinModelPortaliE7EQR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074878.

Family and domain databases

Gene3Di1.10.560.10. 1 hit.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.

Sequencei

Sequence statusi: Complete.

E7EQR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKIIGING DFFANMVVDA VLAIKYTDIR GQPRYPVNSV NILKAHGRSQ
60 70 80 90 100
MESMLISGYA LNCVVGSQGM PKRIVNAKIA CLDFSLQKTK MKLGVQVVIT
110 120 130 140 150
DPEKLDQIRQ RESDITKERI QKILATGANV ILTTGGIDDM CLKYFVEAGA
160 170 180 190 200
MAVRRVLKRD LKRIAKASGA TILSTLANLE GEETFEAAML GQAEEVVQER
210 220 230 240 250
ICDDELILIK NTKARTSASI ILRGANDFMC DEMERSLHDA LCVVKRVLES
260 270 280 290 300
KSVVPGGGAV EAALSIYLEN YATSMGSREQ LAIAEFARSL LVIPNTLAVN
310 320 330 340 350
AAQDSTDLVA KLRAFHNEAQ VNPERKNLKW IGLDLSNGKP RDNKQAGVFE
360 370 380 390 400
PTIVKVKSLK FATEAAITIL RIDDLIKLHP ESKDDKHGSY EDAVHSGALN

D
Length:401
Mass (Da):43,886
Last modified:March 8, 2011 - v1
Checksum:iAAE1912CB35EBF2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135914 Genomic DNA. No translation available.
RefSeqiNP_001008897.1. NM_001008897.1.
UniGeneiHs.363137.

Genome annotation databases

EnsembliENST00000392168; ENSP00000376008; ENSG00000120438.
GeneIDi6950.
UCSCiuc003qss.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135914 Genomic DNA. No translation available.
RefSeqiNP_001008897.1. NM_001008897.1.
UniGeneiHs.363137.

3D structure databases

ProteinModelPortaliE7EQR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317334.

PTM databases

iPTMnetiE7EQR6.

Proteomic databases

MaxQBiE7EQR6.
PaxDbiE7EQR6.
PeptideAtlasiE7EQR6.
PRIDEiE7EQR6.

Protocols and materials databases

DNASUi6950.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392168; ENSP00000376008; ENSG00000120438.
GeneIDi6950.
UCSCiuc003qss.4. human.

Organism-specific databases

CTDi6950.
HGNCiHGNC:11655. TCP1.
OpenTargetsiENSG00000120438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074878.

Miscellaneous databases

ChiTaRSiTCP1. human.
GenomeRNAii6950.

Gene expression databases

BgeeiENSG00000120438.
ExpressionAtlasiE7EQR6. baseline and differential.
GenevisibleiE7EQR6. HS.

Family and domain databases

Gene3Di1.10.560.10. 1 hit.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE7EQR6_HUMAN
AccessioniPrimary (citable) accession number: E7EQR6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.