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E7EQN5 (E7EQN5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Rho GTPase-activating protein 4 Ensembl ENSP00000359033
Gene names
Name:ARHGAP4 Ensembl ENSP00000359033
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000359033
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length925 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH3 domain. RuleBase RU003338

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000359033

Sequences

Sequence LengthMass (Da)Tools
E7EQN5 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: F70A580535B3DC2C

FASTA925102,571
        10         20         30         40         50         60 
MAAHGKLRRE RGLQAEYETQ VKEMRWQLSE QLRCLELQGE LRRELLQELA EFMRRRAEVE 

        70         80         90        100        110        120 
LEYSRGLEKL AERFSSRGGR LGSSREHQSF RKEPSLLSPL HCWAVLLQHT RQQSRESAAL 

       130        140        150        160        170        180 
SEVLAGPLAQ RLSHIAEDVG RLVKKAKKTY QAYHMESVNA EAKLREAERQ EEKRAGRSVP 

       190        200        210        220        230        240 
TTTAGATEAG PLRKSSLKKG GRLVEKRQAK FMEHKLKCTK ARNEYLLSLA SVNAAVSNYY 

       250        260        270        280        290        300 
LHDVLDLMDC CDTGFHLALG QVLRSYTAAE SRTQASQVQG LGSLEEAVEA LDPPGDKAKV 

       310        320        330        340        350        360 
LEVHATVFCP PLRFDYHPHD GDEVAEICVE MELRDEILPR AQNIQSRLDR QTIETEEVNK 

       370        380        390        400        410        420 
TLKATLQALL EVVASDDGDV LDSFQTSPST ESLKSTSSDP GSRQAGRRRG QQQETETFYL 

       430        440        450        460        470        480 
TKLQEYLSGR SILAKLQAKH EKLQEALQRG DKEEQEVSWT QYTQRKFQKS RQPRPSSQYN 

       490        500        510        520        530        540 
QRLFGGDMEK FIQSSGQPVP LVVESCIRFI NLNGLQHEGI FRVSGAQLRV SEIRDAFERG 

       550        560        570        580        590        600 
EDPLVEGCTA HDLDSVAGVL KLYFRSLEPP LFPPDLFGEL LASSELEATA ERVEHVSRLL 

       610        620        630        640        650        660 
WRLPAPVLVV LRYLFTFLNH LAQYSDENMM DPYNLAVCFG PTLLPVPAGQ DPVALQGRVN 

       670        680        690        700        710        720 
QLVQTLIVQP DRVFPPLTSL PGPVYEKCMA PPSASCLGDA QLESLGADNE PELEAEMPAQ 

       730        740        750        760        770        780 
EDDLEGVVEA VACFAYTGRT AQELSFRRGD VLRLHERASS DWWRGEHNGM RGLIPHKYIT 

       790        800        810        820        830        840 
LPAGTEKQVV GAGLQTAGES GSSPEGLLAS ELVHRPEPCT SPEAMGPSGH RRRCLVPASP 

       850        860        870        880        890        900 
EQHVEVDKAV AQNMDSVFKE LLGKTSVRQG LGPASTTSPS PGPRSPKAPP SSRLGRNKGF 

       910        920 
SRGPGAPASP SASHPQGLDT TPKPH

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U52112 Genomic DNA. No translation available.
IPIIPI00642835.

3D structure databases

ProteinModelPortalE7EQN5.
SMRE7EQN5. Positions 481-674, 730-827.
ModBaseSearch...

Proteomic databases

PRIDEE7EQN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370016; ENSP00000359033; ENSG00000089820.

Organism-specific databases

HGNCHGNC:674. ARHGAP4.
GenAtlasSearch...

Gene expression databases

ArrayExpressE7EQN5.
BgeeE7EQN5.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48350. Rho_GAP. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35499915.

Entry information

Entry nameE7EQN5_HUMAN
AccessionPrimary (citable) accession number: E7EQN5
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info