ID   E7EQF3_HUMAN            Unreviewed;       118 AA.
AC   E7EQF3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Glycophorin {ECO:0000256|PIRNR:PIRNR002466};
GN   Name=GYPA {ECO:0000313|Ensembl:ENSP00000425549.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425549.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425549.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000425549.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC107223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E7EQF3; -.
DR   SMR; E7EQF3; -.
DR   MassIVE; E7EQF3; -.
DR   PeptideAtlas; E7EQF3; -.
DR   ProteomicsDB; 17561; -.
DR   Antibodypedia; 3054; 2241 antibodies from 47 providers.
DR   Ensembl; ENST00000504786.5; ENSP00000425549.1; ENSG00000170180.22.
DR   UCSC; uc003ijp.5; human.
DR   HGNC; HGNC:4702; GYPA.
DR   VEuPathDB; HostDB:ENSG00000170180; -.
DR   GeneTree; ENSGT00550000075214; -.
DR   ChiTaRS; GYPA; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000170180; Expressed in trabecular bone tissue and 111 other cell types or tissues.
DR   ExpressionAtlas; E7EQF3; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.70; -; 1.
DR   InterPro; IPR001195; Glycophorin.
DR   InterPro; IPR018938; Glycophorin_CS.
DR   InterPro; IPR049535; GYPA_B.
DR   PANTHER; PTHR13813; GLYCOPHORIN; 1.
DR   PANTHER; PTHR13813:SF2; GLYCOPHORIN-B; 1.
DR   Pfam; PF01102; Glycophorin_A; 1.
DR   PIRSF; PIRSF002466; Glycophorin; 2.
DR   PROSITE; PS00312; GLYCOPHORIN_A; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|PIRNR:PIRNR002466};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002466, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:E7EQF3,
KW   ECO:0007829|PeptideAtlas:E7EQF3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Sialic acid {ECO:0000256|ARBA:ARBA00022981, ECO:0000256|PIRNR:PIRNR002466};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..118
FT                   /note="Glycophorin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003219456"
FT   TRANSMEM        60..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          89..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   118 AA;  12762 MW;  B37446EE9A31560A CRC64;
     MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGERVQ LAHHFSEPEI
     TLIIFGVMAG VIGTILLISY GIRRLIKKSP SDVKPLPSPD TDVPLSSVEI ENPETSDQ
//