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Protein
Submitted name:

MDS1 and EVI1 complex locus protein EVI1

Gene

MECOM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MDS1 and EVI1 complex locus protein EVI1Imported
Gene namesi
Name:MECOMImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3498. MECOM.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000085276.

PTM / Processingi

Proteomic databases

MaxQBiE7EQ57.
PaxDbiE7EQ57.
PeptideAtlasiE7EQ57.
PRIDEiE7EQ57.

Expressioni

Gene expression databases

BgeeiENSG00000085276.
ExpressionAtlasiE7EQ57. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000264674.

Structurei

3D structure databases

ProteinModelPortaliE7EQ57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 190SETInterPro annotationAdd BLAST113
Domaini209 – 237C2H2-typeInterPro annotationAdd BLAST29
Domaini263 – 290C2H2-typeInterPro annotationAdd BLAST28
Domaini291 – 318C2H2-typeInterPro annotationAdd BLAST28
Domaini319 – 347C2H2-typeInterPro annotationAdd BLAST29
Domaini348 – 375C2H2-typeInterPro annotationAdd BLAST28
Domaini376 – 403C2H2-typeInterPro annotationAdd BLAST28
Domaini405 – 432C2H2-typeInterPro annotationAdd BLAST28
Domaini912 – 939C2H2-typeInterPro annotationAdd BLAST28
Domaini940 – 968C2H2-typeInterPro annotationAdd BLAST29
Domaini969 – 996C2H2-typeInterPro annotationAdd BLAST28

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063676.
OMAiPRNTEER.
OrthoDBiEOG091G0BYE.
PhylomeDBiE7EQ57.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EQ57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA
60 70 80 90 100
TSSEAFTPKE GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI
110 120 130 140 150
EVGEKFGPYV GEQRSNLKDP SYGWEILDEF YNVKFCIDAS QPDVGSWLKY
160 170 180 190 200
IRFAGCYDQH NLVACQINDQ IFYRVVADIA PGEELLLFMK SEDYPHETMA
210 220 230 240 250
PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS MVEEDFQQKL
260 270 280 290 300
ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
310 320 330 340 350
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC
360 370 380 390 400
PECGKTFATS SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD
410 420 430 440 450
CRTQIKCKDC GQMFSTTSSL NKHRRFCEGK NHFAAGGFFG QGISLPGTPA
460 470 480 490 500
MDKTSMVNMS HANPGLADYF GANRHPAGLT FPTAPGFSFS FPGLFPSGLY
510 520 530 540 550
HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD ILKALSKHPS
560 570 580 590 600
VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
610 620 630 640 650
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE
660 670 680 690 700
QTAVSGAVND SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF
710 720 730 740 750
PAFSQSMYPF PDRDLRSLPL KMEPQSPGEV KKLQKGSSES PFDLTTKRKD
760 770 780 790 800
EKPLTPVPSK PPVTPATSQD QPLDLSMGSR SRASGTKLTE PRKNHVFGGK
810 820 830 840 850
KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL EALKEKYLRP
860 870 880 890 900
SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
910 920 930 940 950
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS
960 970 980 990 1000
ISSNLQRHVR NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA
1010 1020 1030 1040 1050
TSSPHSELES TGAILDDKED AYFTEIRNFI GNSNHGSQSP RNVEERMNGS
1060 1070 1080 1090 1100
HFKDEKALVT SQNSDLLDDE EVEDEVLLDE EDEDNDITGK TGKEPVTSNL
1110 1120 1130 1140 1150
HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH IRHFTDSLKM
1160 1170 1180 1190 1200
RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
1210 1220 1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV
Length:1,230
Mass (Da):138,136
Last modified:March 8, 2011 - v1
Checksum:i49E9B7CBCD422042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007849 Genomic DNA. No translation available.
AC024099 Genomic DNA. No translation available.
AC069220 Genomic DNA. No translation available.
AC074033 Genomic DNA. No translation available.
AC078985 Genomic DNA. No translation available.
KF457717 Genomic DNA. No translation available.
RefSeqiXP_005247272.1. XM_005247215.3.
UniGeneiHs.744090.

Genome annotation databases

EnsembliENST00000494292; ENSP00000417899; ENSG00000085276.
GeneIDi2122.
UCSCiuc062ptz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007849 Genomic DNA. No translation available.
AC024099 Genomic DNA. No translation available.
AC069220 Genomic DNA. No translation available.
AC074033 Genomic DNA. No translation available.
AC078985 Genomic DNA. No translation available.
KF457717 Genomic DNA. No translation available.
RefSeqiXP_005247272.1. XM_005247215.3.
UniGeneiHs.744090.

3D structure databases

ProteinModelPortaliE7EQ57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264674.

Proteomic databases

MaxQBiE7EQ57.
PaxDbiE7EQ57.
PeptideAtlasiE7EQ57.
PRIDEiE7EQ57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000494292; ENSP00000417899; ENSG00000085276.
GeneIDi2122.
UCSCiuc062ptz.1. human.

Organism-specific databases

CTDi2122.
HGNCiHGNC:3498. MECOM.
OpenTargetsiENSG00000085276.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063676.
OMAiPRNTEER.
OrthoDBiEOG091G0BYE.
PhylomeDBiE7EQ57.

Miscellaneous databases

ChiTaRSiMECOM. human.
GenomeRNAii2122.

Gene expression databases

BgeeiENSG00000085276.
ExpressionAtlasiE7EQ57. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7EQ57_HUMAN
AccessioniPrimary (citable) accession number: E7EQ57
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.