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E7EPP6

- E7EPP6_HUMAN

UniProt

E7EPP6 - E7EPP6_HUMAN

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Protein
Submitted name: Serine/threonine-protein kinase Chk1
Gene
CHEK1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Enzyme and pathway databases

    SignaLinkiE7EPP6.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Serine/threonine-protein kinase Chk1Imported
    Gene namesi
    Name:CHEK1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1925. CHEK1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: HPA
    2. nucleus Source: HPA
    Complete GO annotation...

    Expressioni

    Gene expression databases

    ArrayExpressiE7EPP6.
    BgeeiE7EPP6.

    Structurei

    3D structure databases

    ProteinModelPortaliE7EPP6.
    SMRiE7EPP6. Positions 47-326.

    Family & Domainsi

    Phylogenomic databases

    OMAiISTSPFW.
    PhylomeDBiE7EPP6.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7EPP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSAVLKSLQ PGSLPDCKAA LGGSGNISTS PFWSRRHSEG QDTGTRAVLL    50
    YGAGARVCGS VTPSSFGGKS AAFGFLQWWA KDSPPRCSVE SWQCPLWKTG 100
    TWCKPWEKVP MEKPDIGMPE PDAQRFFHQL MAGVVYLHGI GITHRDIKPE 150
    NLLLDERDNL KISDFGLATV FRYNNRERLL NKMCGTLPYV APELLKRREF 200
    HAEPVDVWSC GIVLTAMLAG ELPWDQPSDS CQEYSDWKEK KTYLNPWKKI 250
    DSAPLALLHK ILVENPSARI TIPDIKKDRW YNKPLKKGAK RPRVTSGGVS 300
    ESPSGFSKHI QSNLDFSPVN SASSEENVKY SSSQPEPRTG LSLWDTSPSY 350
    IDKLVQGISF SQPTCPDHML LNSQLLGTPG SSQNPWQRLV KRMTRFFTKL 400
    DADKSYQCLK ETCEKLGYQW KKSCMNQVTI STTDRRNNKL IFKVNLLEMD 450
    DKILVDFRLS KGDGLEFKRH FLKIKGKLID IVSSQKIWLP AT 492
    Length:492
    Mass (Da):55,518
    Last modified:March 8, 2011 - v1
    Checksum:i0EF4C429D747EEA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001132 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000427383; ENSP00000391090; ENSG00000149554.
    UCSCiuc010sbh.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001132 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E7EPP6.
    SMRi E7EPP6. Positions 47-326.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427383 ; ENSP00000391090 ; ENSG00000149554 .
    UCSCi uc010sbh.2. human.

    Organism-specific databases

    HGNCi HGNC:1925. CHEK1.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi ISTSPFW.
    PhylomeDBi E7EPP6.

    Enzyme and pathway databases

    SignaLinki E7EPP6.

    Miscellaneous databases

    ChiTaRSi CHEK1. human.
    NextBioi 35499778.

    Gene expression databases

    ArrayExpressi E7EPP6.
    Bgeei E7EPP6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7EPP6_HUMAN
    AccessioniPrimary (citable) accession number: E7EPP6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: July 9, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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