ID E7EPJ1_HUMAN Unreviewed; 462 AA. AC E7EPJ1; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 2. DT 27-MAR-2024, entry version 77. DE SubName: Full=Ras and Rab interactor 2 {ECO:0000313|Ensembl:ENSP00000391239.2}; GN Name=RIN2 {ECO:0000313|Ensembl:ENSP00000391239.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391239.2, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000391239.2, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000391239.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family. CC {ECO:0000256|ARBA:ARBA00006919}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL049538; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL121761; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL132821; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E7EPJ1; -. DR SMR; E7EPJ1; -. DR IntAct; E7EPJ1; 2. DR MassIVE; E7EPJ1; -. DR MaxQB; E7EPJ1; -. DR PeptideAtlas; E7EPJ1; -. DR ProteomicsDB; 17372; -. DR Antibodypedia; 24653; 98 antibodies from 20 providers. DR Ensembl; ENST00000440354.2; ENSP00000391239.2; ENSG00000132669.14. DR UCSC; uc010gcu.3; human. DR HGNC; HGNC:18750; RIN2. DR VEuPathDB; HostDB:ENSG00000132669; -. DR GeneTree; ENSGT00940000154866; -. DR HOGENOM; CLU_651433_0_0_1; -. DR ChiTaRS; RIN2; human. DR Proteomes; UP000005640; Chromosome 20. DR Bgee; ENSG00000132669; Expressed in choroid plexus epithelium and 206 other cell types or tissues. DR ExpressionAtlas; E7EPJ1; baseline and differential. DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro. DR CDD; cd16131; RA_Rin2; 1. DR Gene3D; 3.30.505.10; SH2 domain; 1. DR Gene3D; 1.20.1050.80; VPS9 domain; 1. DR InterPro; IPR000159; RA_dom. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR InterPro; IPR003123; VPS9. DR InterPro; IPR045046; Vps9-like. DR InterPro; IPR037191; VPS9_dom_sf. DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1. DR PANTHER; PTHR23101:SF51; RAS AND RAB INTERACTOR 2; 1. DR Pfam; PF00788; RA; 1. DR Pfam; PF02204; VPS9; 1. DR SMART; SM00314; RA; 1. DR SMART; SM00167; VPS9; 1. DR SUPFAM; SSF55550; SH2 domain; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR SUPFAM; SSF109993; VPS9 domain; 1. DR PROSITE; PS50200; RA; 1. DR PROSITE; PS51205; VPS9; 1. PE 1: Evidence at protein level; KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}; KW Proteomics identification {ECO:0007829|EPD:E7EPJ1, KW ECO:0007829|MaxQB:E7EPJ1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 185..324 FT /note="VPS9" FT /evidence="ECO:0000259|PROSITE:PS51205" FT DOMAIN 354..445 FT /note="Ras-associating" FT /evidence="ECO:0000259|PROSITE:PS50200" SQ SEQUENCE 462 AA; 53116 MW; 6A1E7DCC946413C7 CRC64; MTAWTMGARG LDKRGSFFKL IDTIASEIGE LKQEMVRTDV NLENGLEPAE THSMVRHKDG GYSEEEDVKT CARDSGYDSL SNRLSILDRL LHTHPIWLQL SLSEEEAAEV LQAQPPGIFL VHKSTKMQKK VLSLRLPCEF GAPLKEFAIK ESTYNVVLEK AMHKCILKPL KGHVEAMLKD FHMADGSWKQ LKENLQLVRQ RNPQELGVFA PTPDFVDVEK IKVKFMTMQK MYSPEKKVML LLRVCKLIYT VMENNSGRMY GADDFLPVLT YVIAQCDMLE LDTEIEYMME LLDPSLLHGE GGYYLTSAYG ALSLIKNFQE EQAARLLSSE TRDTLRQWHK RRTTNRTIPS VDDFQNYLRV AFQEVNSGCT GKTLLVRPYI TTEDVCQICA EKFKVGDPEE YSLFLFVDET WQQLAEDTYP QKIKAELHSR PQPHIFHFVY KRIKNDPYGI IFQNGEEDLT TS //