E7ENR4 (E7ENR4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hexokinase-1 Ensembl ENSP00000402103

Gene names

Name:

HK1 Ensembl ENSP00000402103

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000402103

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	952 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000402103

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS022672
Ligand	ATP-binding SAAS SAAS022672 Nucleotide-binding
Molecular function	Kinase SAAS SAAS022672 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E7ENR4 [UniParc]. Last modified March 8, 2011. Version 1. Checksum: 25580B25DFC09FF9	FASTA	952	106,314
	10 20 30 40 50 60 MGQICQRESR QGLAMLPRLF LNPWRQVILL PQPPKVLGLQ ATAAEKPKLH LLAESEIDKY 70 80 90 100 110 120 LYAMRLSDET LIDIMTRFRK EMKNGLSRDF NPTATVKMLP TFVRSIPDGS EKGDFIALDL 130 140 150 160 170 180 GGSSFRILRV QVNHEKNQNV HMESEVYDTP ENIVHGSGSQ LFDHVAECLG DFMEKRKIKD 190 200 210 220 230 240 KKLPVGFTFS FPCQQSKIDE AILITWTKRF KASGVEGADV VKLLNKAIKK RGDYDANIVA 250 260 270 280 290 300 VVNDTVGTMM TCGYDDQHCE VGLIIGTGTN ACYMEELRHI DLVEGDEGRM CINTEWGAFG 310 320 330 340 350 360 DDGSLEDIRT EFDREIDRGS LNPGKQLFEK MVSGMYLGEL VRLILVKMAK EGLLFEGRIT 370 380 390 400 410 420 PELLTRGKFN TSDVSAIEKN KEGLHNAKEI LTRLGVEPSD DDCVSVQHVC TIVSFRSANL 430 440 450 460 470 480 VAATLGAILN RLRDNKGTPR LRTTVGVDGS LYKTHPQYSR RFHKTLRRLV PDSDVRFLLS 490 500 510 520 530 540 ESGSGKGAAM VTAVAYRLAE QHRQIEETLA HFHLTKDMLL EVKKRMRAEM ELGLRKQTHN 550 560 570 580 590 600 NAVVKMLPSF VRRTPDGTEN GDFLALDLGG TNFRVLLVKI RSGKKRTVEM HNKIYAIPIE 610 620 630 640 650 660 IMQGTGEELF DHIVSCISDF LDYMGIKGPR MPLGFTFSFP CQQTSLDAGI LITWTKGFKA 670 680 690 700 710 720 TDCVGHDVVT LLRDAIKRRE EFDLDVVAVV NDTVGTMMTC AYEEPTCEVG LIVGTGSNAC 730 740 750 760 770 780 YMEEMKNVEM VEGDQGQMCI NMEWGAFGDN GCLDDIRTHY DRLVDEYSLN AGKQRYEKMI 790 800 810 820 830 840 SGMYLGEIVR NILIDFTKKG FLFRGQISET LKTRGIFETK FLSQIESDRL ALLQVRAILQ 850 860 870 880 890 900 QLGLNSTCDD SILVKTVCGV VSRRAAQLCG AGMAAVVDKI RENRGLDRLN VTVGVDGTLY 910 920 930 940 950 KLHPHFSRIM HQTVKELSPK CNVSFLLSED GSGKGAALIT AVGVRLRTEA SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (NOV-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC016821 Genomic DNA. No translation available. AL596223 Genomic DNA. No translation available. AL672126 Genomic DNA. No translation available.
IPI	IPI00903226.
3D structure databases
ProteinModelPortal	E7ENR4.
SMR	E7ENR4. Positions 56-949.
ModBase	Search...
Proteomic databases
PRIDE	E7ENR4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000448642; ENSP00000402103; ENSG00000156515.
UCSC	uc001jpj.4. human.
Organism-specific databases
HGNC	HGNC:4922. HK1.
GenAtlas	Search...
Phylogenomic databases
OMA	DFTKRGF.
Gene expression databases
ArrayExpress	E7ENR4.
Bgee	E7ENR4.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 2 hits. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HK1. human.
NextBio	35499642.

Entry information

Entry name

E7ENR4_HUMAN

Accession

Primary (citable) accession number: E7ENR4

Entry history

Integrated into UniProtKB/TrEMBL:	March 8, 2011
Last sequence update:	March 8, 2011
Last modified:	April 3, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.