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Protein
Submitted name:

Filamin-B

Gene

FLNB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Filamin-BImported
Gene namesi
Name:FLNBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3755. FLNB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136068.

PTM / Processingi

Proteomic databases

MaxQBiE7EN95.
PaxDbiE7EN95.
PeptideAtlasiE7EN95.
PRIDEiE7EN95.

Expressioni

Gene expression databases

BgeeiENSG00000136068.
ExpressionAtlasiE7EN95. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000420213.

Structurei

3D structure databases

ProteinModelPortaliE7EN95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00660000095431.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.60.40.10. 24 hits.
InterProiIPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR029874. FLNB.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF238. PTHR11915:SF238. 1 hit.
PfamiPF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EN95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEHSTRRRS LSLCPDWESW DPQKPVDNAR EAMQQADDWL GVPQVITPEE
60 70 80 90 100
IIHPDVDEHS VMTYLSQFPK AKLKPGAPLK PKLNPKKARA YGRGIEPTGN
110 120 130 140 150
MVKQPAKFTV DTISAGQGDV MVFVEDPEGN KEEAQVTPDS DKNKTYSVEY
160 170 180 190 200
LPKVTGLHKV TVLFAGQHIS KSPFEVSVDK AQGDASKVTA KGPGLEAVGN
210 220 230 240 250
IANKPTYFDI YTAGAGVGDI GVEVEDPQGK NTVELLVEDK GNQVYRCVYK
260 270 280 290 300
PMQPGPHVVK IFFAGDTIPK SPFVVQVGEA CNPNACRASG RGLQPKGVRI
310 320 330 340 350
RETTDFKVDT KAAGSGELGV TMKGPKGLEE LVKQKDFLDG VYAFEYYPST
360 370 380 390 400
PGRYSIAITW GGHHIPKSPF EVQVGPEAGM QKVRAWGPGL HGGIVGRSAD
410 420 430 440 450
FVVESIGSEV GSLGFAIEGP SQAKIEYNDQ NDGSCDVKYW PKEPGEYAVH
460 470 480 490 500
IMCDDEDIKD SPYMAFIHPA TGGYNPDLVR AYGPGLEKSG CIVNNLAEFT
510 520 530 540 550
VDPKDAGKAP LKIFAQDGEG QRIDIQMKNR MDGTYACSYT PVKAIKHTIA
560 570 580 590 600
VVWGGVNIPH SPYRVNIGQG SHPQKVKVFG PGVERSGLKA NEPTHFTVDC
610 620 630 640 650
TEAGEGDVSV GIKCDARVLS EDEEDVDFDI IHNANDTFTV KYVPPAAGRY
660 670 680 690 700
TIKVLFASQE IPASPFRVKV DPSHDASKVK AEGPGLSKAG VENGKPTHFT
710 720 730 740 750
VYTKGAGKAP LNVQFNSPLP GDAVKDLDII DNYDYSHTVK YTPTQQGNMQ
760 770 780 790 800
VLVTYGGDPI PKSPFTVGVA APLDLSKIKL NGLENRVEVG KDQEFTVDTR
810 820 830 840 850
GAGGQGKLDV TILSPSRKVV PCLVTPVTGR ENSTAKFIPR EEGLYAVDVT
860 870 880 890 900
YDGHPVPGSP YTVEASLPPD PSKVKAHGPG LEGGLVGKPA EFTIDTKGAG
910 920 930 940 950
TGGLGLTVEG PCEAKIECSD NGDGTCSVSY LPTKPGEYFV NILFEEVHIP
960 970 980 990 1000
GSPFKADIEM PFDPSKVVAS GPGLEHGKVG EAGLLSVDCS EAGPGALGLE
1010 1020 1030 1040 1050
AVSDSGTKAE VSIQNNKDGT YAVTYVPLTA GMYTLTMKYG GELVPHFPAR
1060 1070 1080 1090 1100
VKVEPAVDTS RIKVFGPGIE GKDVFREATT DFTVDSRPLT QVGGDHIKAH
1110 1120 1130 1140 1150
IANPSGASTE CFVTDNADGT YQVEYTPFEK GLHVVEVTYD DVPIPNSPFK
1160 1170 1180 1190 1200
VAVTEGCQPS RVQAQGPGLK EAFTNKPNVF TVVTRGAGIG GLGITVEGPS
1210 1220 1230 1240 1250
ESKINCRDNK DGSCSAEYIP FAPGDYDVNI TYGGAHIPGS PFRVPVKDVV
1260 1270 1280 1290 1300
DPSKVKIAGP GLGSGVRARV LQSFTVDSSK AGLAPLEVRV LGPRGLVEPV
1310 1320 1330 1340 1350
NVVDNGDGTH TVTYTPSQEG PYMVSVKYAD EEIPRSPFKV KVLPTYDASK
1360 1370 1380 1390 1400
VTASGPGLSS YGVPASLPVD FAIDARDAGE GLLAVQITDQ EGKPKRAIVH
1410 1420 1430 1440 1450
DNKDGTYAVT YIPDKTGRYM IGVTYGGDDI PLSPYRIRAT QTGDASKCLA
1460 1470 1480 1490 1500
TGPGIASTVK TGEEVGFVVD AKTAGKGKVT CTVLTPDGTE AEADVIENED
1510 1520 1530 1540 1550
GTYDIFYTAA KPGTYVIYVR FGGVDIPNSP FTVMVTEEAY VPVSDMNGLG
1560 1570 1580 1590 1600
FKPFDLVIPF AVRKGEITGE VHMPSGKTAT PEIVDNKDGT VTVRYAPTEV
1610 1620 1630 1640 1650
GLHEMHIKYM GSHIPESPLQ FYVNYPNSGS VSAYGPGLVY GVANKTATFT
1660 1670 1680 1690 1700
IVTEDAGEGG LDLAIEGPSK AEISCIDNKD GTCTVTYLPT LPGDYSILVK
1710 1720 1730 1740 1750
YNDKHIPGSP FTAKITDDSR RCSQVKLGSA ADFLLDISET DLSSLTASIK
1760 1770 1780 1790 1800
APSGRDEPCL LKRLPNNHIG ISFIPREVGE HLVSIKKNGN HVANSPVSIM
1810 1820 1830 1840 1850
VVQSEIGDAR RAKVYGRGLS EGRTFEMSDF IVDTRDAGYG GISLAVEGPS
1860 1870 1880 1890 1900
KVDIQTEDLE DGTCKVSYFP TVPGVYIVST KFADEHVPGS PFTVKISGEG
1910 1920 1930 1940 1950
RVKESITRTS RAPSVATVGS ICDLNLKIPE INSSDMSAHV TSPSGRVTEA
1960 1970 1980 1990 2000
EIVPMGKNSH CVRFVPQEMG VHTVSVKYRG QHVTGSPFQF TVGPLGEGGA
2010 2020 2030 2040 2050
HKVRAGGPGL ERGEAGVPAE FSIWTREAGA GGLSIAVEGP SKAEITFDDH
2060 2070 2080 2090 2100
KNGSCGVSYI AQEPGNYEVS IKFNDEHIPE SPYLVPVIAP SDDARRLTVM
2110 2120 2130 2140 2150
SLQESGLKVN QPASFAIRLN GAKGKIDAKV HSPSGAVEEC HVSELEPDKY
2160 2170 2180 2190 2200
AVRFIPHENG VHTIDVKFNG SHVVGSPFKV RVGEPGQAGN PALVSAYGTG
2210 2220 2230 2240 2250
LEGGTTGIQS EFFINTTRAG PGTLSVTIEG PSKVKMDCQE TPEGYKVMYT
2260 2270 2280 2290 2300
PMAPGNYLIS VKYGGPNHIV GSPFKAKVTG QRLVSPGSAN ETSSILVESV
2310 2320 2330 2340 2350
TRSSTETCYS AIPKASSDAS KVTSKGAGLS KAFVGQKSSF LVDCSKAGSN
2360 2370 2380 2390 2400
MLLIGVHGPT TPCEEVSMKH VGNQQYNVTY VVKERGDYVL AVKWGEEHIP

GSPFHVTVP
Length:2,409
Mass (Da):256,281
Last modified:March 8, 2011 - v1
Checksum:i62099547AE4BE890
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114399 Genomic DNA. No translation available.
AC137936 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000493452; ENSP00000418510; ENSG00000136068.
UCSCiuc003djm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114399 Genomic DNA. No translation available.
AC137936 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE7EN95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000420213.

Proteomic databases

MaxQBiE7EN95.
PaxDbiE7EN95.
PeptideAtlasiE7EN95.
PRIDEiE7EN95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493452; ENSP00000418510; ENSG00000136068.
UCSCiuc003djm.3. human.

Organism-specific databases

HGNCiHGNC:3755. FLNB.
OpenTargetsiENSG00000136068.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00660000095431.

Miscellaneous databases

ChiTaRSiFLNB. human.

Gene expression databases

BgeeiENSG00000136068.
ExpressionAtlasiE7EN95. baseline and differential.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.60.40.10. 24 hits.
InterProiIPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR029874. FLNB.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF238. PTHR11915:SF238. 1 hit.
PfamiPF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7EN95_HUMAN
AccessioniPrimary (citable) accession number: E7EN95
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.