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E7EN01

- E7EN01_HUMAN

UniProt

E7EN01 - E7EN01_HUMAN

Protein
Submitted name:

Calcitonin gene-related peptide type 1 receptor

Gene

CALCRL

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. calcitonin gene-related peptide receptor activity Source: Ensembl
    2. calcitonin receptor activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. heart development Source: Ensembl
    3. negative regulation of inflammatory response Source: Ensembl
    4. positive regulation of smooth muscle cell proliferation Source: Ensembl
    5. regulation of muscle contraction Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Calcitonin gene-related peptide type 1 receptorImported
    Gene namesi
    Name:CALCRLImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16709. CALCRL.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Expressioni

    Gene expression databases

    ArrayExpressiE7EN01.
    BgeeiE7EN01.

    Structurei

    3D structure databases

    ProteinModelPortaliE7EN01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR003289. GPCR_2_CGRP1_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    [Graphical view]
    PRINTSiPR01351. CGRPRECEPTOR.
    PR01350. CTRFAMILY.
    PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E7EN01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ   50
    KIMQDPIQQA EGVYCNRTWD GWLCWND 77
    Length:77
    Mass (Da):9,082
    Last modified:May 14, 2014 - v2
    Checksum:iFA550A5DF6813189
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei77 – 771Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007319 Genomic DNA. No translation available.
    AC074020 Genomic DNA. No translation available.
    KF456755 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000447403; ENSP00000415626; ENSG00000064989.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007319 Genomic DNA. No translation available.
    AC074020 Genomic DNA. No translation available.
    KF456755 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E7EN01.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000447403 ; ENSP00000415626 ; ENSG00000064989 .

    Organism-specific databases

    HGNCi HGNC:16709. CALCRL.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35499530.

    Gene expression databases

    ArrayExpressi E7EN01.
    Bgeei E7EN01.

    Family and domain databases

    InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR003289. GPCR_2_CGRP1_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    [Graphical view ]
    PRINTSi PR01351. CGRPRECEPTOR.
    PR01350. CTRFAMILY.
    PROSITEi PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE7EN01_HUMAN
    AccessioniPrimary (citable) accession number: E7EN01
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 24 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3