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Protein
Submitted name:

Adhesion G protein-coupled receptor L3

Gene

ADGRL3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor L3Imported
Gene namesi
Name:ADGRL3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:20974. ADGRL3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei879 – 90224HelicalSequence analysisAdd
BLAST
Transmembranei914 – 93219HelicalSequence analysisAdd
BLAST
Transmembranei938 – 96023HelicalSequence analysisAdd
BLAST
Transmembranei981 – 100121HelicalSequence analysisAdd
BLAST
Transmembranei1021 – 104424HelicalSequence analysisAdd
BLAST
Transmembranei1065 – 108824HelicalSequence analysisAdd
BLAST
Transmembranei1094 – 111724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 12311212Sequence analysisPRO_5003218958Add
BLAST

Proteomic databases

PaxDbiE7EMR3.

Expressioni

Gene expression databases

BgeeiE7EMR3.
ExpressionAtlasiE7EMR3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000422533.

Structurei

3D structure databases

ProteinModelPortaliE7EMR3.
SMRiE7EMR3. Positions 29-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 12490SUEL-type lectinInterPro annotationAdd
BLAST
Domaini134 – 393260Olfactomedin-likeInterPro annotationAdd
BLAST
Domaini498 – 55457G_PROTEIN_RECEP_F2_3InterPro annotationAdd
BLAST
Domaini815 – 86652GPSInterPro annotationAdd
BLAST
Domaini877 – 1118242G_PROTEIN_RECEP_F2_4InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SUEL-type lectin domain.UniRule annotation
Contains GPS domain.SAAS annotation
Contains olfactomedin-like domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410XSD2. LUCA.
KOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
GeneTreeiENSGT00820000126962.
OrthoDBiEOG76DTRK.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR015630. Latrophilin-3.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF60. PTHR12011:SF60. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EMR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPSQLLIFM MLLAPIIHAF SRAPIPMAVV RRELSCESYP IELRCPGTDV
60 70 80 90 100
IMIESANYGR TDDKICDSDP AQMENIRCYL PDAYKIMSQR CNNRTQCAVV
110 120 130 140 150
AGPDVFPDPC PGTYKYLEVQ YECVPYKVEQ KVFLCPGLLK GVYQSEHLFE
160 170 180 190 200
SDHQSGAWCK DPLQASDKIY YMPWTPYRTD TLTEYSSKDD FIAGRPTTTY
210 220 230 240 250
KLPHRVDGTG FVVYDGALFF NKERTRNIVK FDLRTRIKSG EAIIANANYH
260 270 280 290 300
DTSPYRWGGK SDIDLAVDEN GLWVIYATEQ NNGKIVISQL NPYTLRIEGT
310 320 330 340 350
WDTAYDKRSA SNAFMICGIL YVVKSVYEDD DNEATGNKID YIYNTDQSKD
360 370 380 390 400
SLVDVPFPNS YQYIAAVDYN PRDNLLYVWN NYHVVKYSLD FGPLDSRSGQ
410 420 430 440 450
AHHGQVSYIS PPIHLDSELE RPSVKDISTT GPLGMGSTTT STTLRTTTLS
460 470 480 490 500
PGRSTTPSVS GRRNRSTSTP SPAVEVLDDM TTHLPSASSQ IPALEESCEA
510 520 530 540 550
VEAREIMWFK TRQGQIAKQP CPAGTIGVST YLCLAPDGIW DPQGPDLSNC
560 570 580 590 600
SSPWVNHITQ KLKSGETAAN IARELAEQTR NHLNAGDITY SVRAMDQLVG
610 620 630 640 650
LLDVQLRNLT PGGKDSAARS LNKLQKRERS CRAYVQAMVE TVNNLLQPQA
660 670 680 690 700
LNAWRDLTTS DQLRAATMLL HTVEESAFVL ADNLLKTDIV RENTDNIKLE
710 720 730 740 750
VARLSTEGNL EDLKFPENMG HGSTIQLSAN TLKQNGRNGE IRVAFVLYNN
760 770 780 790 800
LGPYLSTENA SMKLGTEALS TNHSVIVNSP VITAAINKEF SNKVYLADPV
810 820 830 840 850
VFTVKHIKQS EENFNPNCSF WSYSKRTMTG YWSTQGCRLL TTNKTHTTCS
860 870 880 890 900
CNHLTNFAVL MAHVEVKHSD AVHDLLLDVI TWVGILLSLV CLLICIFTFC
910 920 930 940 950
FFRGLQSDRN TIHKNLCISL FVAELLFLIG INRTDQPIAC AVFAALLHFF
960 970 980 990 1000
FLAAFTWMFL EGVQLYIMLV EVFESEHSRR KYFYLVGYGM PALIVAVSAA
1010 1020 1030 1040 1050
VDYRSYGTDK VCWLRLDTYF IWSFIGPATL IIMLNVIFLG IALYKMFHHT
1060 1070 1080 1090 1100
AILKPESGCL DNIKSWVIGA IALLCLLGLT WAFGLMYINE STVIMAYLFT
1110 1120 1130 1140 1150
IFNSLQGMFI FIFHCVLQKK VRKEYGKCLR THCCSGKSTE SSIGSGKTSG
1160 1170 1180 1190 1200
SRTPGRYSTG SQSRIRRMWN DTVRKQSESS FITGDINSSA SLNREPYRET
1210 1220 1230
SMGVKLNIAY QIGASEQCQG YKCHGYSTTE W
Length:1,231
Mass (Da):138,131
Last modified:March 8, 2011 - v1
Checksum:i60BADA8FE90FFCE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020741 Genomic DNA. No translation available.
AC092643 Genomic DNA. No translation available.
AC092668 Genomic DNA. No translation available.
AC096723 Genomic DNA. No translation available.
AC104813 Genomic DNA. No translation available.
AC108161 Genomic DNA. No translation available.
KF457762 Genomic DNA. No translation available.
KF457763 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000506700; ENSP00000424120; ENSG00000150471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020741 Genomic DNA. No translation available.
AC092643 Genomic DNA. No translation available.
AC092668 Genomic DNA. No translation available.
AC096723 Genomic DNA. No translation available.
AC104813 Genomic DNA. No translation available.
AC108161 Genomic DNA. No translation available.
KF457762 Genomic DNA. No translation available.
KF457763 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE7EMR3.
SMRiE7EMR3. Positions 29-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000422533.

Proteomic databases

PaxDbiE7EMR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506700; ENSP00000424120; ENSG00000150471.

Organism-specific databases

HGNCiHGNC:20974. ADGRL3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410XSD2. LUCA.
KOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
GeneTreeiENSGT00820000126962.
OrthoDBiEOG76DTRK.

Miscellaneous databases

ChiTaRSiLPHN3. human.
NextBioi35499491.

Gene expression databases

BgeeiE7EMR3.
ExpressionAtlasiE7EMR3. baseline and differential.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR015630. Latrophilin-3.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF60. PTHR12011:SF60. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE7EMR3_HUMAN
AccessioniPrimary (citable) accession number: E7EMR3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: January 20, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.