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Protein

Serine protease 44

Gene

PRSS44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137Charge relay systemBy similarity1
Active sitei184Charge relay systemBy similarity1
Active sitei284Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 44 (EC:3.4.21.-)
Alternative name(s):
Testis serine protease 4
Short name:
TESSP-4
Gene namesi
Name:PRSS44
Synonyms:TESSP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:37324. PRSS44.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000041369828 – 344Serine protease 44Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 138PROSITE-ProRule annotation
Disulfide bondi218 ↔ 290PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 270PROSITE-ProRule annotation
Disulfide bondi280 ↔ 308PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiE7EML9.

Structurei

3D structure databases

ProteinModelPortaliE7EML9.
SMRiE7EML9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 332Peptidase S1PROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiE7EML9.
PhylomeDBiE7EML9.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E7EML9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQSGSSLG LLAWFLLLQP WLEEARAGRV GAQGGVALLF PSALPSGPGG
60 70 80 90 100
QDPGASGWEP PPVGAPGSPA APQSRGNAVR PASVLLPSAC GQRTSRITGG
110 120 130 140 150
LPAPDRKWPW QVSLQTSNRH ICGGSLIARH WVLTAAHCIS GHLEYTVKLG
160 170 180 190 200
DTNVHHRSKT ALVVPVRDVV IHRYFTSPGI IENDIALALL DFPVNYSTHI
210 220 230 240 250
QLVCLPEQAF MVQAGTNCWV TGWGKVNETE KIVTEPQEAE LSIILHDKCN
260 270 280 290 300
EVLKEKIRMR SEMVKKGTIC GYNDQGKDAC QGDSGGPLVC ELNGTWVQVG
310 320 330 340
IVSWGIGCGR KGYPGVYTEV SFYKKWIIDH LRQASCLNSK TSSS
Length:344
Mass (Da):36,995
Last modified:December 14, 2011 - v3
Checksum:i28EEE9E5C179B36D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109583 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiPRS44_HUMAN
AccessioniPrimary (citable) accession number: E7EML9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: December 14, 2011
Last modified: May 10, 2017
This is version 38 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families