ID   E7EMG9_HUMAN            Unreviewed;       275 AA.
AC   E7EMG9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Lymphocyte specific protein 1 {ECO:0000313|Ensembl:ENSP00000400346.1};
DE   Flags: Fragment;
GN   Name=LSP1 {ECO:0000313|Ensembl:ENSP00000400346.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400346.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400346.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0007829|PubMed:19367720}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19367720; DOI=10.1021/pr800500r;
RA   Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
RT   "Phosphorylation analysis of primary human T lymphocytes using sequential
RT   IMAC and titanium oxide enrichment.";
RL   J. Proteome Res. 7:5167-5176(2008).
RN   [3] {ECO:0007829|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [4] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0007829|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [6] {ECO:0000313|Ensembl:ENSP00000400346.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC051649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E7EMG9; -.
DR   SMR; E7EMG9; -.
DR   MassIVE; E7EMG9; -.
DR   MaxQB; E7EMG9; -.
DR   PeptideAtlas; E7EMG9; -.
DR   ProteomicsDB; 16938; -.
DR   Antibodypedia; 4493; 707 antibodies from 40 providers.
DR   Ensembl; ENST00000457279.5; ENSP00000400346.1; ENSG00000130592.17.
DR   UCSC; uc057xun.1; human.
DR   HGNC; HGNC:6707; LSP1.
DR   VEuPathDB; HostDB:ENSG00000130592; -.
DR   GeneTree; ENSGT00940000153901; -.
DR   ChiTaRS; LSP1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000130592; Expressed in granulocyte and 101 other cell types or tissues.
DR   ExpressionAtlas; E7EMG9; baseline and differential.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR006018; Caldesmon_LSP.
DR   InterPro; IPR002211; Lymphspecific.
DR   PANTHER; PTHR18949; CALDESMON; 1.
DR   PANTHER; PTHR18949:SF1; LYMPHOCYTE-SPECIFIC PROTEIN 1; 1.
DR   Pfam; PF02029; Caldesmon; 1.
DR   PRINTS; PR01083; LYMPHSPCIFIC.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:E7EMG9,
KW   ECO:0007829|MaxQB:E7EMG9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          1..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         275
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000400346.1"
SQ   SEQUENCE   275 AA;  30613 MW;  076A4612F8B0B078 CRC64;
     MLEERSEARP TAQWSVEDEE EAVHEQCQHE RDRQLQAQDE EGGGHVPERP KQEMLLSLKP
     SEAPELDEDE GFGDWSQRPE QRQQHEGAQG ALDSGEPPQC RSPEGEQEDR PGLHAYEKED
     SDEVHLEELS LSKEGPGPED TVQDNLGAAG AEEEQEEHQK CQQPRTPSPL VLEGTIEQSS
     PPLSPTTKLI DRTESLNRSI EKSNSVKKSQ PDLPISKIDQ WLEQYTQAIE TAGRTPKLAR
     QASIELPSMA VASTKSRWET GEVQAQSAAK TPSCK
//