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Protein

Tyrosine-protein phosphatase

Gene

PTPN18

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN18Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000072135.12.
HGNCiHGNC:9649. PTPN18.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072135.

PTM / Processingi

Proteomic databases

MaxQBiE7EMB8.
PaxDbiE7EMB8.
PeptideAtlasiE7EMB8.
PRIDEiE7EMB8.

Expressioni

Gene expression databases

BgeeiENSG00000072135.
ExpressionAtlasiE7EMB8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE7EMB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 96Tyrosine-protein phosphataseInterPro annotationAdd BLAST96
Domaini10 – 87TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140780.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Fragment.

E7EMB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XDRGVPSSPD HMLAMVEEAR RLQGSGPEPL CVHCSAGCGR TGVLCTVDYV
60 70 80 90 100
RQLLLTQMIP PDFSLFDVVL KMRKQRPAAV QTEEQYRFLY HTVAQMFCST
110 120 130 140 150
LQNASPHYQN IKENCAPLYD DALFLRTPQA LLAIPRPPGG VLRSISVPGS
160 170 180 190 200
PGHAMADTYA VVQKRGAPAG AGSGTQTGTG TGTGARSAEE APLYSKVTPR
210 220 230 240 250
AQRPGAHAED ARGTLPGRVP ADQSPAGSGA YEDVAGGAQT GGLGFNLRIG
260
RPKGPRDPPA EWTRVSLDL
Length:269
Mass (Da):28,510
Last modified:June 26, 2013 - v2
Checksum:iCE8F11CD3A610F8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132479 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000409022; ENSP00000387031; ENSG00000072135.
UCSCiuc061num.1. human.

Entry informationi

Entry nameiE7EMB8_HUMAN
AccessioniPrimary (citable) accession number: E7EMB8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 26, 2013
Last modified: October 25, 2017
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported