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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase N2

Gene

PTPRN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase N2Imported
Gene namesi
Name:PTPRN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9677. PTPRN2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500321745822 – 977Sequence analysisAdd BLAST956

Proteomic databases

PaxDbiE7EM83.
PeptideAtlasiE7EM83.
PRIDEiE7EM83.

Expressioni

Gene expression databases

BgeeiENSG00000155093.
ExpressionAtlasiE7EM83. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374069.

Structurei

3D structure databases

ProteinModelPortaliE7EM83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini707 – 967Tyrosine-protein phosphataseInterPro annotationAdd BLAST261
Domaini886 – 958TYR_PHOSPHATASE_2InterPro annotationAdd BLAST73

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0793. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR021613. Receptor_IA-2_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7EM83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE
60 70 80 90 100
ACVNGFTWQD DYTQYVMDQE LADLPKTYLR RPEASSPARP SKHSVGSERR
110 120 130 140 150
YSREGGAALA NALRRHLPFL EALSQAPASD VLARTHTAQD RPPAEGDDRF
160 170 180 190 200
SESILTYVAH TSALTYPPGS RTQLREDLLP RTLGQLQPDE LSPKVDSGVD
210 220 230 240 250
RHHLMAALSA YAAQRPPAPP GEGSLEPQYL LRAPSRMPRP LLAPAAPQKW
260 270 280 290 300
PSPLGDSEDP SSTGDGARIH TLLKDLQRQP AEVRGLSGLE LDGMAELMAG
310 320 330 340 350
LMQGVDHGVA RGSPGRAALG ESGEQADGPK ATLRGDSFPD DGVQDDDDRL
360 370 380 390 400
YQEVHRLSAT LGGLLQDHGS RLLPGALPFA RPLDMERKKS EHPESSLSSE
410 420 430 440 450
EETAGVENVK SQTYSKDLLG QQPHSEPGAA AFGELQNQMP GPSKEEQSLP
460 470 480 490 500
AGAQEALSDG LQLEVQPSEE EARGYIVTDR DPLRPEEGRR LVEDVARLLQ
510 520 530 540 550
VPSSAFADVE VLGPAVTFKV SANVQNVTTE DVEKATVDNK DKLEETSGLK
560 570 580 590 600
ILQTGVGSKS KLKFLPPQAE QEDSTKFIAL TLVSLACILG VLLASGLIYC
610 620 630 640 650
LRHSSQHRLK EKLSGLGGDP GADATAAYQE LCRQRMATRP PDRPEGPHTS
660 670 680 690 700
RISSVSSQFS DGPIPSPSAR SSASSWSEEP VQSNMDISTG HMILSYMEDH
710 720 730 740 750
LKNKNRLEKE WEALCAYQAE PNSSFVAQRE ENVPKNRSLA VLTYDHSRVL
760 770 780 790 800
LKAENSHSHS DYINASPIMD HDPRNPAYIA TQGPLPATVA DFWQMVWESG
810 820 830 840 850
CVVIVMLTPL AENGVRQCYH YWPDEGSNLY HIYEVNLVSE HIWCEDFLVR
860 870 880 890 900
SFYLKNLQTN ETRTVTQFHF LSWYDRGVPS SSRSLLDFRR KVNKCYRGRS
910 920 930 940 950
CPIIVHCSDG AGRSGTYVLI DMVLNKMAKG AKEIDIAATL EHLRDQRPGM
960 970
VQTKEQFEFA LTAVAEEVNA ILKALPQ
Length:977
Mass (Da):106,989
Last modified:March 8, 2011 - v1
Checksum:iD3297D96062D85F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
KF458646 Genomic DNA. No translation available.
KF510998 Genomic DNA. No translation available.
KF510999 Genomic DNA. No translation available.
RefSeqiNP_001295196.1. NM_001308267.1.
UniGeneiHs.490789.

Genome annotation databases

EnsembliENST00000409483; ENSP00000387114; ENSG00000155093.
GeneIDi5799.
UCSCiuc003wnr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
KF458646 Genomic DNA. No translation available.
KF510998 Genomic DNA. No translation available.
KF510999 Genomic DNA. No translation available.
RefSeqiNP_001295196.1. NM_001308267.1.
UniGeneiHs.490789.

3D structure databases

ProteinModelPortaliE7EM83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000374069.

Proteomic databases

PaxDbiE7EM83.
PeptideAtlasiE7EM83.
PRIDEiE7EM83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409483; ENSP00000387114; ENSG00000155093.
GeneIDi5799.
UCSCiuc003wnr.4. human.

Organism-specific databases

CTDi5799.
HGNCiHGNC:9677. PTPRN2.
OpenTargetsiENSG00000155093.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0793. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.

Miscellaneous databases

ChiTaRSiPTPRN2. human.
GenomeRNAii5799.

Gene expression databases

BgeeiENSG00000155093.
ExpressionAtlasiE7EM83. baseline and differential.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR021613. Receptor_IA-2_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7EM83_HUMAN
AccessioniPrimary (citable) accession number: E7EM83
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.