E7EM69 (E7EM69_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Aquaporin-1 Ensembl ENSP00000387178

Gene names

Name:

AQP1 Ensembl ENSP00000387178

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000387178

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the MIP/aquaporin family. RuleBase RU000477
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000387178

Ontologies

Keywords
Biological process	Transport RuleBase RU000477
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000477
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E7EM69 [UniParc]. Last modified March 8, 2011. Version 1. Checksum: 409D14C5A0F352CE	FASTA	218	23,425
	10 20 30 40 50 60 MFWTFGYEAV SPAGPSHLFA SLLLGVLLTI TFMPGARPLP LVLVPQNTLA WMQLDAKAPA 70 80 90 100 110 120 HPRPLQLLGR VGPGSRQLAD GVNSGQGLGI EIIGTLQLVL CVLATTDRRR RDLGGSAPLA 130 140 150 160 170 180 IGLSVALGHL LAIDYTGCGI NPARSFGSAV ITHNFSNHWI FWVGPFIGGA LAVLIYDFIL 190 200 210 APRSSDLTDR VKVWTSGQVE EYDLDADDIN SRVEMKPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004691 Genomic DNA. No translation available. AC005155 Genomic DNA. No translation available.
IPI	IPI00915781.
RefSeq	NP_001171990.1. NM_001185061.1.
UniGene	Hs.76152.
3D structure databases
ProteinModelPortal	E7EM69.
SMR	E7EM69. Positions 2-218.
ModBase	Search...
Proteomic databases
PRIDE	E7EM69.
Protocols and materials databases
DNASU	358.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409611; ENSP00000387178; ENSG00000240583.
GeneID	358.
KEGG	hsa:358.
UCSC	uc010kwh.1. human.
Organism-specific databases
CTD	358.
HGNC	HGNC:633. AQP1.
GenAtlas	Search...
Phylogenomic databases
KO	K09864.
Gene expression databases
ArrayExpress	E7EM69.
Bgee	E7EM69.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR023274. Aquaporin_1. IPR000425. MIP. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR02013. AQUAPORIN1. PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	358.
NextBio	1497.

Entry information

Entry name

E7EM69_HUMAN

Accession

Primary (citable) accession number: E7EM69

Entry history

Integrated into UniProtKB/TrEMBL:	March 8, 2011
Last sequence update:	March 8, 2011
Last modified:	May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.