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E7DN64

- DAMS_SOLLC

UniProt

E7DN64 - DAMS_SOLLC

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Protein

Delta-amyrin synthase

Gene

TTS2

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Multifunctional oxidosqualene cyclase producing delta-amyrin (48%), alpha-amyrin (18%), beta-amyrin (13%) and 4 other minor triterpenes.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin.1 Publication
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication
(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.1 Publication

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17972.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-amyrin synthase (EC:5.4.99.55)
Alternative name(s):
Alpha-amyrin synthase (EC:5.4.99.40)
Beta-amyrin synthase (EC:5.4.99.39)
Triterpenoid synthase 2
Short name:
SlTTS2
Gene namesi
Name:TTS2
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Delta-amyrin synthasePRO_0000413971Add
BLAST

Expressioni

Tissue specificityi

Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1Add
BLAST
Repeati513 – 55846PFTB 2Add
BLAST
Repeati590 – 63041PFTB 3Add
BLAST
Repeati639 – 68042PFTB 4Add
BLAST
Repeati701 – 74242PFTB 5Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiE7DN64.
KOiK15813.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7DN64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWKLKIAKGQ DDRYLYSTNN YIGRQIWEFD PNAGTIEEQA KIEEARQHYW
60 70 80 90 100
NNRYKVKPNS DLLWRMQFLR EKNFKQRIRA VKVEEGEEIS HEIATVALHR
110 120 130 140 150
AVHFFSALQA TDGHWPAESA GPLFFLPPLV MCMYITGHLN TVFPAEHRKE
160 170 180 190 200
ILRYIYCHQN EDGGWGLHIE GHSTMFCTAM SYICMRILGE GPEGGVNNAC
210 220 230 240 250
ARARKWILDH GSVIAIPSWG KTWLSILGAF EWIGTNPMPP EFWILPSFLP
260 270 280 290 300
VHPAKMWCYC RTVYMPMSYL YGKRFVGPIT PLILKLREEL YDQTYDEINW
310 320 330 340 350
KKVRHVCAKE DLYYPHPFVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV
360 370 380 390 400
TMKHIHYEDE NSRYITMGCV EKVLSMLACW VEDPNGDHFK KHLARIPDFL
410 420 430 440 450
WVAEDGMKMQ GCGSQSWDAS LAIQALLASE MNDEISDTLK NGHDFIKQSQ
460 470 480 490 500
VKDNPSGDFK VMYRHISKGS WAFADQDLGW QVSDCTAEAL KCCLLFSTMP
510 520 530 540 550
PEIVGEAMDP VRLYDSVNVI LSLQSKNGGL SAWEPAGAPE YLELLNPTEF
560 570 580 590 600
FEDIVIEHEH VECTSSAIQA LVRFKKLYPG HRTTEVDNFI NNGVKYIEDV
610 620 630 640 650
QEPDGSWYGN WGVCFIYASW FALGGLAAVG LSYSNCAAVR KSVEFLLRTQ
660 670 680 690 700
RSDGGWGESY RSCPDKVYRE LETEHSNLVQ TAWALMGLIH SGQVERDPRP
710 720 730 740 750
LHRAAKLLIN FQMEDGDFPQ QEITGVFLRN CMMHYALYRN IFPLWGLAEY
760
RRNVLVPLKH NYI
Length:763
Mass (Da):88,036
Last modified:March 8, 2011 - v1
Checksum:i0CD81BBC15F49BEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ266580 mRNA. Translation: ADU52575.1.
RefSeqiNP_001234597.1. NM_001247668.2.
UniGeneiLes.18888.

Genome annotation databases

GeneIDi100529100.
KEGGisly:100529100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ266580 mRNA. Translation: ADU52575.1 .
RefSeqi NP_001234597.1. NM_001247668.2.
UniGenei Les.18888.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100529100.
KEGGi sly:100529100.

Phylogenomic databases

InParanoidi E7DN64.
KOi K15813.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17972.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids."
    Wang Z., Guhling O., Yao R., Li F., Yeats T., Rose J., Jetter R.
    Plant Physiol. 155:540-552(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    Strain: cv. MicroTom.

Entry informationi

Entry nameiDAMS_SOLLC
AccessioniPrimary (citable) accession number: E7DN64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3