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E7DN64

- DAMS_SOLLC

UniProt

E7DN64 - DAMS_SOLLC

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Protein
Delta-amyrin synthase
Gene
TTS2
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Multifunctional oxidosqualene cyclase producing delta-amyrin (48%), alpha-amyrin (18%), beta-amyrin (13%) and 4 other minor triterpenes.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin.1 Publication
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication
(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.1 Publication

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17972.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-amyrin synthase (EC:5.4.99.55)
Alternative name(s):
Alpha-amyrin synthase (EC:5.4.99.40)
Beta-amyrin synthase (EC:5.4.99.39)
Triterpenoid synthase 2
Short name:
SlTTS2
Gene namesi
Name:TTS2
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Delta-amyrin synthase
PRO_0000413971Add
BLAST

Expressioni

Tissue specificityi

Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1
Add
BLAST
Repeati513 – 55846PFTB 2
Add
BLAST
Repeati590 – 63041PFTB 3
Add
BLAST
Repeati639 – 68042PFTB 4
Add
BLAST
Repeati701 – 74242PFTB 5
Add
BLAST

Sequence similaritiesi

Contains 5 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK15813.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7DN64-1 [UniParc]FASTAAdd to Basket

« Hide

MWKLKIAKGQ DDRYLYSTNN YIGRQIWEFD PNAGTIEEQA KIEEARQHYW    50
NNRYKVKPNS DLLWRMQFLR EKNFKQRIRA VKVEEGEEIS HEIATVALHR 100
AVHFFSALQA TDGHWPAESA GPLFFLPPLV MCMYITGHLN TVFPAEHRKE 150
ILRYIYCHQN EDGGWGLHIE GHSTMFCTAM SYICMRILGE GPEGGVNNAC 200
ARARKWILDH GSVIAIPSWG KTWLSILGAF EWIGTNPMPP EFWILPSFLP 250
VHPAKMWCYC RTVYMPMSYL YGKRFVGPIT PLILKLREEL YDQTYDEINW 300
KKVRHVCAKE DLYYPHPFVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV 350
TMKHIHYEDE NSRYITMGCV EKVLSMLACW VEDPNGDHFK KHLARIPDFL 400
WVAEDGMKMQ GCGSQSWDAS LAIQALLASE MNDEISDTLK NGHDFIKQSQ 450
VKDNPSGDFK VMYRHISKGS WAFADQDLGW QVSDCTAEAL KCCLLFSTMP 500
PEIVGEAMDP VRLYDSVNVI LSLQSKNGGL SAWEPAGAPE YLELLNPTEF 550
FEDIVIEHEH VECTSSAIQA LVRFKKLYPG HRTTEVDNFI NNGVKYIEDV 600
QEPDGSWYGN WGVCFIYASW FALGGLAAVG LSYSNCAAVR KSVEFLLRTQ 650
RSDGGWGESY RSCPDKVYRE LETEHSNLVQ TAWALMGLIH SGQVERDPRP 700
LHRAAKLLIN FQMEDGDFPQ QEITGVFLRN CMMHYALYRN IFPLWGLAEY 750
RRNVLVPLKH NYI 763
Length:763
Mass (Da):88,036
Last modified:March 8, 2011 - v1
Checksum:i0CD81BBC15F49BEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ266580 mRNA. Translation: ADU52575.1.
RefSeqiNP_001234597.1. NM_001247668.2.
UniGeneiLes.18888.

Genome annotation databases

GeneIDi100529100.
KEGGisly:100529100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ266580 mRNA. Translation: ADU52575.1 .
RefSeqi NP_001234597.1. NM_001247668.2.
UniGenei Les.18888.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100529100.
KEGGi sly:100529100.

Phylogenomic databases

KOi K15813.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17972.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids."
    Wang Z., Guhling O., Yao R., Li F., Yeats T., Rose J., Jetter R.
    Plant Physiol. 155:540-552(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    Strain: cv. MicroTom.

Entry informationi

Entry nameiDAMS_SOLLC
AccessioniPrimary (citable) accession number: E7DN64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 8, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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