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E7DN64

- DAMS_SOLLC

UniProt

E7DN64 - DAMS_SOLLC

Protein

Delta-amyrin synthase

Gene

TTS2

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Multifunctional oxidosqualene cyclase producing delta-amyrin (48%), alpha-amyrin (18%), beta-amyrin (13%) and 4 other minor triterpenes.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin.1 Publication
    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.1 Publication

    GO - Molecular functioni

    1. intramolecular transferase activity Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17972.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-amyrin synthase (EC:5.4.99.55)
    Alternative name(s):
    Alpha-amyrin synthase (EC:5.4.99.40)
    Beta-amyrin synthase (EC:5.4.99.39)
    Triterpenoid synthase 2
    Short name:
    SlTTS2
    Gene namesi
    Name:TTS2
    OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
    Taxonomic identifieri4081 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
    ProteomesiUP000004994: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Delta-amyrin synthasePRO_0000413971Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati148 – 18942PFTB 1Add
    BLAST
    Repeati513 – 55846PFTB 2Add
    BLAST
    Repeati590 – 63041PFTB 3Add
    BLAST
    Repeati639 – 68042PFTB 4Add
    BLAST
    Repeati701 – 74242PFTB 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 5 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    KOiK15813.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7DN64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKLKIAKGQ DDRYLYSTNN YIGRQIWEFD PNAGTIEEQA KIEEARQHYW    50
    NNRYKVKPNS DLLWRMQFLR EKNFKQRIRA VKVEEGEEIS HEIATVALHR 100
    AVHFFSALQA TDGHWPAESA GPLFFLPPLV MCMYITGHLN TVFPAEHRKE 150
    ILRYIYCHQN EDGGWGLHIE GHSTMFCTAM SYICMRILGE GPEGGVNNAC 200
    ARARKWILDH GSVIAIPSWG KTWLSILGAF EWIGTNPMPP EFWILPSFLP 250
    VHPAKMWCYC RTVYMPMSYL YGKRFVGPIT PLILKLREEL YDQTYDEINW 300
    KKVRHVCAKE DLYYPHPFVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV 350
    TMKHIHYEDE NSRYITMGCV EKVLSMLACW VEDPNGDHFK KHLARIPDFL 400
    WVAEDGMKMQ GCGSQSWDAS LAIQALLASE MNDEISDTLK NGHDFIKQSQ 450
    VKDNPSGDFK VMYRHISKGS WAFADQDLGW QVSDCTAEAL KCCLLFSTMP 500
    PEIVGEAMDP VRLYDSVNVI LSLQSKNGGL SAWEPAGAPE YLELLNPTEF 550
    FEDIVIEHEH VECTSSAIQA LVRFKKLYPG HRTTEVDNFI NNGVKYIEDV 600
    QEPDGSWYGN WGVCFIYASW FALGGLAAVG LSYSNCAAVR KSVEFLLRTQ 650
    RSDGGWGESY RSCPDKVYRE LETEHSNLVQ TAWALMGLIH SGQVERDPRP 700
    LHRAAKLLIN FQMEDGDFPQ QEITGVFLRN CMMHYALYRN IFPLWGLAEY 750
    RRNVLVPLKH NYI 763
    Length:763
    Mass (Da):88,036
    Last modified:March 8, 2011 - v1
    Checksum:i0CD81BBC15F49BEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ266580 mRNA. Translation: ADU52575.1.
    RefSeqiNP_001234597.1. NM_001247668.2.
    UniGeneiLes.18888.

    Genome annotation databases

    GeneIDi100529100.
    KEGGisly:100529100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ266580 mRNA. Translation: ADU52575.1 .
    RefSeqi NP_001234597.1. NM_001247668.2.
    UniGenei Les.18888.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100529100.
    KEGGi sly:100529100.

    Phylogenomic databases

    KOi K15813.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17972.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids."
      Wang Z., Guhling O., Yao R., Li F., Yeats T., Rose J., Jetter R.
      Plant Physiol. 155:540-552(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
      Strain: cv. MicroTom.

    Entry informationi

    Entry nameiDAMS_SOLLC
    AccessioniPrimary (citable) accession number: E7DN64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3