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Protein

Delta-amyrin synthase

Gene

TTS2

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional oxidosqualene cyclase producing delta-amyrin (48%), alpha-amyrin (18%), beta-amyrin (13%) and 4 other minor triterpenes.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin.1 Publication
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication
(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17972.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-amyrin synthase (EC:5.4.99.55)
Alternative name(s):
Alpha-amyrin synthase (EC:5.4.99.40)
Beta-amyrin synthase (EC:5.4.99.39)
Triterpenoid synthase 2
Short name:
SlTTS2
Gene namesi
Name:TTS2
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Delta-amyrin synthasePRO_0000413971Add
BLAST

Expressioni

Tissue specificityi

Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc12g006520.1.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1Add
BLAST
Repeati513 – 55846PFTB 2Add
BLAST
Repeati590 – 63041PFTB 3Add
BLAST
Repeati639 – 68042PFTB 4Add
BLAST
Repeati701 – 74242PFTB 5Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiE7DN64.
KOiK15813.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7DN64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKLKIAKGQ DDRYLYSTNN YIGRQIWEFD PNAGTIEEQA KIEEARQHYW
60 70 80 90 100
NNRYKVKPNS DLLWRMQFLR EKNFKQRIRA VKVEEGEEIS HEIATVALHR
110 120 130 140 150
AVHFFSALQA TDGHWPAESA GPLFFLPPLV MCMYITGHLN TVFPAEHRKE
160 170 180 190 200
ILRYIYCHQN EDGGWGLHIE GHSTMFCTAM SYICMRILGE GPEGGVNNAC
210 220 230 240 250
ARARKWILDH GSVIAIPSWG KTWLSILGAF EWIGTNPMPP EFWILPSFLP
260 270 280 290 300
VHPAKMWCYC RTVYMPMSYL YGKRFVGPIT PLILKLREEL YDQTYDEINW
310 320 330 340 350
KKVRHVCAKE DLYYPHPFVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV
360 370 380 390 400
TMKHIHYEDE NSRYITMGCV EKVLSMLACW VEDPNGDHFK KHLARIPDFL
410 420 430 440 450
WVAEDGMKMQ GCGSQSWDAS LAIQALLASE MNDEISDTLK NGHDFIKQSQ
460 470 480 490 500
VKDNPSGDFK VMYRHISKGS WAFADQDLGW QVSDCTAEAL KCCLLFSTMP
510 520 530 540 550
PEIVGEAMDP VRLYDSVNVI LSLQSKNGGL SAWEPAGAPE YLELLNPTEF
560 570 580 590 600
FEDIVIEHEH VECTSSAIQA LVRFKKLYPG HRTTEVDNFI NNGVKYIEDV
610 620 630 640 650
QEPDGSWYGN WGVCFIYASW FALGGLAAVG LSYSNCAAVR KSVEFLLRTQ
660 670 680 690 700
RSDGGWGESY RSCPDKVYRE LETEHSNLVQ TAWALMGLIH SGQVERDPRP
710 720 730 740 750
LHRAAKLLIN FQMEDGDFPQ QEITGVFLRN CMMHYALYRN IFPLWGLAEY
760
RRNVLVPLKH NYI
Length:763
Mass (Da):88,036
Last modified:March 8, 2011 - v1
Checksum:i0CD81BBC15F49BEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ266580 mRNA. Translation: ADU52575.1.
RefSeqiNP_001234597.1. NM_001247668.2.
UniGeneiLes.18888.

Genome annotation databases

GeneIDi100529100.
KEGGisly:100529100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ266580 mRNA. Translation: ADU52575.1.
RefSeqiNP_001234597.1. NM_001247668.2.
UniGeneiLes.18888.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc12g006520.1.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100529100.
KEGGisly:100529100.

Phylogenomic databases

InParanoidiE7DN64.
KOiK15813.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17972.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids."
    Wang Z., Guhling O., Yao R., Li F., Yeats T., Rose J., Jetter R.
    Plant Physiol. 155:540-552(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    Strain: cv. MicroTom.

Entry informationi

Entry nameiDAMS_SOLLC
AccessioniPrimary (citable) accession number: E7DN64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 8, 2011
Last modified: June 24, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.