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E7DN64 (DAMS_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta-amyrin synthase

EC=5.4.99.55
Alternative name(s):
Alpha-amyrin synthase
EC=5.4.99.40
Beta-amyrin synthase
EC=5.4.99.39
Triterpenoid synthase 2
Short name=SlTTS2
Gene names
Name:TTS2
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Multifunctional oxidosqualene cyclase producing delta-amyrin (48%), alpha-amyrin (18%), beta-amyrin (13%) and 4 other minor triterpenes. Ref.1

Catalytic activity

(3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin. Ref.1

(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin. Ref.1

(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin. Ref.1

Tissue specificity

Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit. Ref.1

Sequence similarities

Belongs to the terpene cyclase/mutase family.

Contains 5 PFTB repeats.

Ontologies

Keywords
   DomainRepeat
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionintramolecular transferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763Delta-amyrin synthase
PRO_0000413971

Regions

Repeat148 – 18942PFTB 1
Repeat513 – 55846PFTB 2
Repeat590 – 63041PFTB 3
Repeat639 – 68042PFTB 4
Repeat701 – 74242PFTB 5

Sequences

Sequence LengthMass (Da)Tools
E7DN64 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 0CD81BBC15F49BEC

FASTA76388,036
        10         20         30         40         50         60 
MWKLKIAKGQ DDRYLYSTNN YIGRQIWEFD PNAGTIEEQA KIEEARQHYW NNRYKVKPNS 

        70         80         90        100        110        120 
DLLWRMQFLR EKNFKQRIRA VKVEEGEEIS HEIATVALHR AVHFFSALQA TDGHWPAESA 

       130        140        150        160        170        180 
GPLFFLPPLV MCMYITGHLN TVFPAEHRKE ILRYIYCHQN EDGGWGLHIE GHSTMFCTAM 

       190        200        210        220        230        240 
SYICMRILGE GPEGGVNNAC ARARKWILDH GSVIAIPSWG KTWLSILGAF EWIGTNPMPP 

       250        260        270        280        290        300 
EFWILPSFLP VHPAKMWCYC RTVYMPMSYL YGKRFVGPIT PLILKLREEL YDQTYDEINW 

       310        320        330        340        350        360 
KKVRHVCAKE DLYYPHPFVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV TMKHIHYEDE 

       370        380        390        400        410        420 
NSRYITMGCV EKVLSMLACW VEDPNGDHFK KHLARIPDFL WVAEDGMKMQ GCGSQSWDAS 

       430        440        450        460        470        480 
LAIQALLASE MNDEISDTLK NGHDFIKQSQ VKDNPSGDFK VMYRHISKGS WAFADQDLGW 

       490        500        510        520        530        540 
QVSDCTAEAL KCCLLFSTMP PEIVGEAMDP VRLYDSVNVI LSLQSKNGGL SAWEPAGAPE 

       550        560        570        580        590        600 
YLELLNPTEF FEDIVIEHEH VECTSSAIQA LVRFKKLYPG HRTTEVDNFI NNGVKYIEDV 

       610        620        630        640        650        660 
QEPDGSWYGN WGVCFIYASW FALGGLAAVG LSYSNCAAVR KSVEFLLRTQ RSDGGWGESY 

       670        680        690        700        710        720 
RSCPDKVYRE LETEHSNLVQ TAWALMGLIH SGQVERDPRP LHRAAKLLIN FQMEDGDFPQ 

       730        740        750        760 
QEITGVFLRN CMMHYALYRN IFPLWGLAEY RRNVLVPLKH NYI 

« Hide

References

[1]"Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids."
Wang Z., Guhling O., Yao R., Li F., Yeats T., Rose J., Jetter R.
Plant Physiol. 155:540-552(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
Strain: cv. MicroTom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HQ266580 mRNA. Translation: ADU52575.1.
RefSeqNP_001234597.1. NM_001247668.2.
UniGeneLes.18888.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100529100.
KEGGsly:100529100.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-17972.

Family and domain databases

Gene3D1.50.10.20. 2 hits.
InterProIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 2 hits.
TIGRFAMsTIGR01787. squalene_cyclas. 1 hit.
PROSITEPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAMS_SOLLC
AccessionPrimary (citable) accession number: E7DN64
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families