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Protein

Beta-amyrin synthase

Gene

TTS1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase converting oxidosqualene into beta-amyrin, generating five rings and eight asymmetric centers in a single transformation.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17974.
BRENDAi5.4.99.39. 3101.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-amyrin synthase (EC:5.4.99.39)
Alternative name(s):
Triterpenoid synthase 1
Short name:
SlTTS1
Gene namesi
Name:TTS1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004139671 – 761Beta-amyrin synthaseAdd BLAST761

Proteomic databases

PaxDbiE7DN63.

Expressioni

Tissue specificityi

Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc12g006530.1.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 189PFTB 1Add BLAST42
Repeati513 – 558PFTB 2Add BLAST46
Repeati590 – 630PFTB 3Add BLAST41
Repeati639 – 680PFTB 4Add BLAST42
Repeati701 – 742PFTB 5Add BLAST42

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0497. Eukaryota.
COG1657. LUCA.
InParanoidiE7DN63.
KOiK15813.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7DN63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKLKIAEGQ NGPYLYSTNN YVGRQTWEFD PNGGTIEERA KIEEARQQFW
60 70 80 90 100
NNRYKVKPSS DLLWRIQFLG EKNFKQKIPA VKVEEGEEIS HEVATIALHR
110 120 130 140 150
AVNFFSALQA TDGHWPAENA GPLFFLPPLV MCMYITGHLN TVFPAEHRKE
160 170 180 190 200
ILRYIYCHQN EDGGWGLHIE GHSTMFCTAL SYICMRILGE GPDGGVNNAC
210 220 230 240 250
ARARKWILDH GSVTAIPSWG KTWLSILGVF EWIGTNPMPP EFWILPSFLP
260 270 280 290 300
VHPAKMWCYC RMVYMPMSYL YGKRFVGPIT PLILQLREEL YDRPYDEINW
310 320 330 340 350
KKVRHVCAKE DLYYPHPLVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV
360 370 380 390 400
TMKHIHYEDE NSRYITIGCV EKVLCMLACW VEDPNGDYFK KHLARIPDYL
410 420 430 440 450
WVAEDGMKMQ SFGSQEWDTG FAIQALLASE MNDEIADTLR KGHDFIKQSQ
460 470 480 490 500
VTNNPSGDFK GMYRHISKGS WTFSDQDHGW QVSDCTAEAL KCCLLLSTMP
510 520 530 540 550
RELVGQAMEP GRLYDSVNVV LSLQSKNGGL AAWEPAGASE YLELLNPTEF
560 570 580 590 600
FADIVIEHEY VECTASSIQA LVLFKKLYPG HRTKEINIFI DNAVKYLEDV
610 620 630 640 650
QMPDGSWYGN WGVCFTYGSW FALGGLVAAG KSYNNSAAVR KGVEFLLRTQ
660 670 680 690 700
RSDGGWGESY RSCPDKVYRE LETNDSNLVQ TAWALMGLIH SGQADRDPKP
710 720 730 740 750
LHRAAKLLIN SQMEDGDFPQ QEITGVFMKN CMLHYAAYRN IYPLWGLAEY
760
RKNVLLPLEN N
Length:761
Mass (Da):87,248
Last modified:March 8, 2011 - v1
Checksum:i313628BF40BA5428
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ266579 mRNA. Translation: ADU52574.1.
RefSeqiNP_001234604.1. NM_001247675.1.
UniGeneiLes.25599.

Genome annotation databases

GeneIDi100529102.
KEGGisly:100529102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ266579 mRNA. Translation: ADU52574.1.
RefSeqiNP_001234604.1. NM_001247675.1.
UniGeneiLes.25599.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc12g006530.1.1.

Proteomic databases

PaxDbiE7DN63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100529102.
KEGGisly:100529102.

Phylogenomic databases

eggNOGiKOG0497. Eukaryota.
COG1657. LUCA.
InParanoidiE7DN63.
KOiK15813.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17974.
BRENDAi5.4.99.39. 3101.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAMS_SOLLC
AccessioniPrimary (citable) accession number: E7DN63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 8, 2011
Last modified: October 5, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.