Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E7DN63 (BAMS_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-amyrin synthase

EC=5.4.99.39
Alternative name(s):
Triterpenoid synthase 1
Short name=SlTTS1
Gene names
Name:TTS1
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Protein attributes

Sequence length761 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidosqualene cyclase converting oxidosqualene into beta-amyrin, generating five rings and eight asymmetric centers in a single transformation. Ref.1

Catalytic activity

(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin. Ref.1

Tissue specificity

Expressed in the leaves and in the epidermal cells but not in the inner tissues of the fruit. Ref.1

Sequence similarities

Belongs to the terpene cyclase/mutase family.

Contains 5 PFTB repeats.

Ontologies

Keywords
   DomainRepeat
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtetracyclic triterpenoid biosynthetic process

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionbaruol synthase activity

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 761761Beta-amyrin synthase
PRO_0000413967

Regions

Repeat148 – 18942PFTB 1
Repeat513 – 55846PFTB 2
Repeat590 – 63041PFTB 3
Repeat639 – 68042PFTB 4
Repeat701 – 74242PFTB 5

Sequences

Sequence LengthMass (Da)Tools
E7DN63 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 313628BF40BA5428

FASTA76187,248
        10         20         30         40         50         60 
MWKLKIAEGQ NGPYLYSTNN YVGRQTWEFD PNGGTIEERA KIEEARQQFW NNRYKVKPSS 

        70         80         90        100        110        120 
DLLWRIQFLG EKNFKQKIPA VKVEEGEEIS HEVATIALHR AVNFFSALQA TDGHWPAENA 

       130        140        150        160        170        180 
GPLFFLPPLV MCMYITGHLN TVFPAEHRKE ILRYIYCHQN EDGGWGLHIE GHSTMFCTAL 

       190        200        210        220        230        240 
SYICMRILGE GPDGGVNNAC ARARKWILDH GSVTAIPSWG KTWLSILGVF EWIGTNPMPP 

       250        260        270        280        290        300 
EFWILPSFLP VHPAKMWCYC RMVYMPMSYL YGKRFVGPIT PLILQLREEL YDRPYDEINW 

       310        320        330        340        350        360 
KKVRHVCAKE DLYYPHPLVQ DLMWDSLYIC TEPLLTRWPF NKLRNKALEV TMKHIHYEDE 

       370        380        390        400        410        420 
NSRYITIGCV EKVLCMLACW VEDPNGDYFK KHLARIPDYL WVAEDGMKMQ SFGSQEWDTG 

       430        440        450        460        470        480 
FAIQALLASE MNDEIADTLR KGHDFIKQSQ VTNNPSGDFK GMYRHISKGS WTFSDQDHGW 

       490        500        510        520        530        540 
QVSDCTAEAL KCCLLLSTMP RELVGQAMEP GRLYDSVNVV LSLQSKNGGL AAWEPAGASE 

       550        560        570        580        590        600 
YLELLNPTEF FADIVIEHEY VECTASSIQA LVLFKKLYPG HRTKEINIFI DNAVKYLEDV 

       610        620        630        640        650        660 
QMPDGSWYGN WGVCFTYGSW FALGGLVAAG KSYNNSAAVR KGVEFLLRTQ RSDGGWGESY 

       670        680        690        700        710        720 
RSCPDKVYRE LETNDSNLVQ TAWALMGLIH SGQADRDPKP LHRAAKLLIN SQMEDGDFPQ 

       730        740        750        760 
QEITGVFMKN CMLHYAAYRN IYPLWGLAEY RKNVLLPLEN N 

« Hide

References

[1]"Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids."
Wang Z., Guhling O., Yao R., Li F., Yeats T., Rose J., Jetter R.
Plant Physiol. 155:540-552(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
Strain: cv. MicroTom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HQ266579 mRNA. Translation: ADU52574.1.
RefSeqNP_001234604.1. NM_001247675.1.
UniGeneLes.25599.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100529102.
KEGGsly:100529102.

Phylogenomic databases

KOK15813.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-17974.

Family and domain databases

Gene3D1.50.10.20. 2 hits.
InterProIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 2 hits.
TIGRFAMsTIGR01787. squalene_cyclas. 1 hit.
PROSITEPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBAMS_SOLLC
AccessionPrimary (citable) accession number: E7DN63
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families